Effect of Combined Detection Value of Serum Vascular Endothelial Growth Factor and other Tumor Markers on Early Diagnosis of Lung Cancer_West China Medical Journal

Authors：

LI Yanping ,  BAO Yong , HE Ping , LIANG Qiuping

Department of Respiratory Medicine, the Third People’s Hospital of Chendu, the Second Clinical Medical College Affiliated to Chongqing Medical University, Chengdu, Sichuan 610031, P. R. China;

Corresponding author：

BAO Yong, Email: alyya@163.com

Keywords：

血管内皮生长因子; 肿瘤标志物; 肺癌; 预后

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【摘要】目的 〖JP2〗探讨血管内皮生长因子（VEGF）联合血清肿瘤标志物对肺癌早期诊断意义。方法 2008年1月-〖JP〗2009年8月收治的92例患者中肺癌患者64例，采集静脉血清标本采用酶联免疫法检测其VEGF水平。结果 64例肺癌与28例非肺癌患者VEGF表达水平分别为（255.72±566.00）、（299.46±795.8） pg/mL，两者比较无统计学意义（P gt;0.05）；43例中晚期肺癌VEGF值（125.07±68.2） pg/mL，表达显著高于12例早期肺癌（196.00±260.60） pg/mL （P lt;0.05）；CEA与CYFRA21-1的表达对判断26例发生胸膜转移的肺癌有统计学意义（P lt;0.05）。结论结合血清VEGF水平和常规肿瘤标志物，可评估现状及临床分期，VEGF结合CEA与CYFRA21-1表达水平为预测肺癌患者早期发生胸膜转移提供理论依据。
【Abstract】 Objective To evaluate the effect of combined detection value of serum vascular endothelial growth factor (VEGF) and tumor markers on early diagnosis of lung cancer. Method Intravenous serum levels of VEGF and tumor markers were assayed by ELISA in 92 patients including 64 lung cancer from January 2008 to August 2009. Results The difference in serum levels of VEGF between the 64 patients with lung cancer [(255.72±566.0) pg/mL] and 28 health adult [(299.46±795.8) pg/mL] was not significant (P gt;0.05). The level of VEGF in 43 patients with middle and late lung cancer [(125.07±68.2) pg/mL] was significantly higher than that in the 12 patients with early lung cancer [(196.00±260.60) pg/mL] (P lt;0.05). There were statistical significance in expression of serum CEA and CYFRA21-1 on diagnosis in 26 patients having lung cancer with early metastasis pleural fluid (P lt;0.05). Conclusion Combined diagnostic of serum VEGF and tumor markers can assess the state of an illness and clinical stage, and the serum levels of serum VEGF,CEA and CYFRA21-1 may be a good predictor for lung cancer with early metastasis pleural fluid.

Citation： LI Yanping,BAO Yong,HE Ping,LIANG Qiuping. Effect of Combined Detection Value of Serum Vascular Endothelial Growth Factor and other Tumor Markers on Early Diagnosis of Lung Cancer. West China Medical Journal, 2010, 25(10): 1808-1810. doi: Copy

1.	Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells[J]. Biochem Biophys Res Commun, 1989, 161(2)∶851-858.
2.	Tomoda M, Maehara Y, Kakeji Y, et al. Intratumoral neovascu-larization and growth pattern in early gastric carcinoma[J]. Cancer, 1999, 85(11)∶2340-2346.
3.	Katsabeki-Katsafli A, Kerenidi T, Kostikas K, et al. Serum vascular endothelial growth factor is related to systemic oxidative stress in patients with lung cancer[J]. Lung Cancer, 2008, 60: 271-276.
4.	郭光祖, 徐洪波. 血清VEGF和EGF检测对肺癌患者的临床意义[J]. 中国医药指南, 2009, 5(7): 32-33.
5.	Sheng H, AOE M, Doihara H, et al. Prognostic value of vascular endothelial growth factor expression in primary lung carcinoma[J]. Acta Med Okayama, 2000, 54(3): 119-126.
6.	Fan XH, Han BH, Dong QG, et al. Vascular endothelial growth factor inhibits dendritic cells from patients with non-small cell lung carcinoma[J]. Chin J Tuberc Respir Dis, 2003, 26(9): 539-543.
7.	Tabernero J. The role of VEGF and EGFR inhibition: implication for combining anti-VEGF and anti-EGFR agents[J]. Mol Cancer Res, 2007, 5: 203-220.
8.	金阳, 高岩, 苏远, 等. 非小细胞肺癌患者血清血管内皮生长因子和基质金属蛋白酶-9水平的变化[J]. 华中科技大学学报医学版, 2006, 35, 328-330.
9.	王水利, 王茁, 罗小峰. 小细胞肺癌患者血清血管内皮生长因子含量水平的临床意义[J]. 现代肿瘤医学, 2006, 14, 810-812.
10.	陈一伟, 吕同德, 高炜. 肺癌患者手术前后血清TNF、EGF含量的临床观察[J]. 放射免疫学杂志[J], 2006, 19, 135-136.
11.	Fontanini G, Faviana P, Lucchi M, et al. A high vascular count and over expression of vascular endothelial growth factor are associated with unfavourable prognosis in operated small cell lung cancer[J]. Br J Cancer, 2002, 86(4): 558-563.
12.	叶超然. 血管内皮生长因子在非小细胞肺癌的表达及其意义[J]. 广西医科大学学报, 2001, 18(4): 478-479.
13.	沙云风, 季之森. 非小细胞肺癌患者血清VEGF、CYFRA21-1及CEA的表达及意义[J]. 医学检验与临床, 2009, 4: 29-31.
14.	李艳萍, 包勇, 殷俊. CYFRA211与TGF-β1联合检测诊断良恶性胸腔积液的意义[J]. 西部医学, 2008, 3(20): 523-524.
15.	Cressey R, Wattananupong O, Lertprasertsuke N, et al. Alteration of protein expression pattern of vascular endothelial growth factor (VEGF) from soluble to cell-associated isoform during tuMourigenesis[J]. BMC Cancer, 2005, 5(2): 128-134.

1. Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells[J]. Biochem Biophys Res Commun, 1989, 161(2)∶851-858.
2. Tomoda M, Maehara Y, Kakeji Y, et al. Intratumoral neovascu-larization and growth pattern in early gastric carcinoma[J]. Cancer, 1999, 85(11)∶2340-2346.
3. Katsabeki-Katsafli A, Kerenidi T, Kostikas K, et al. Serum vascular endothelial growth factor is related to systemic oxidative stress in patients with lung cancer[J]. Lung Cancer, 2008, 60: 271-276.
4. 郭光祖, 徐洪波. 血清VEGF和EGF检测对肺癌患者的临床意义[J]. 中国医药指南, 2009, 5(7): 32-33.
5. Sheng H, AOE M, Doihara H, et al. Prognostic value of vascular endothelial growth factor expression in primary lung carcinoma[J]. Acta Med Okayama, 2000, 54(3): 119-126.
6. Fan XH, Han BH, Dong QG, et al. Vascular endothelial growth factor inhibits dendritic cells from patients with non-small cell lung carcinoma[J]. Chin J Tuberc Respir Dis, 2003, 26(9): 539-543.
7. Tabernero J. The role of VEGF and EGFR inhibition: implication for combining anti-VEGF and anti-EGFR agents[J]. Mol Cancer Res, 2007, 5: 203-220.
8. 金阳, 高岩, 苏远, 等. 非小细胞肺癌患者血清血管内皮生长因子和基质金属蛋白酶-9水平的变化[J]. 华中科技大学学报医学版, 2006, 35, 328-330.
9. 王水利, 王茁, 罗小峰. 小细胞肺癌患者血清血管内皮生长因子含量水平的临床意义[J]. 现代肿瘤医学, 2006, 14, 810-812.
10. 陈一伟, 吕同德, 高炜. 肺癌患者手术前后血清TNF、EGF含量的临床观察[J]. 放射免疫学杂志[J], 2006, 19, 135-136.
11. Fontanini G, Faviana P, Lucchi M, et al. A high vascular count and over expression of vascular endothelial growth factor are associated with unfavourable prognosis in operated small cell lung cancer[J]. Br J Cancer, 2002, 86(4): 558-563.
12. 叶超然. 血管内皮生长因子在非小细胞肺癌的表达及其意义[J]. 广西医科大学学报, 2001, 18(4): 478-479.
13. 沙云风, 季之森. 非小细胞肺癌患者血清VEGF、CYFRA21-1及CEA的表达及意义[J]. 医学检验与临床, 2009, 4: 29-31.
14. 李艳萍, 包勇, 殷俊. CYFRA211与TGF-β1联合检测诊断良恶性胸腔积液的意义[J]. 西部医学, 2008, 3(20): 523-524.
15. Cressey R, Wattananupong O, Lertprasertsuke N, et al. Alteration of protein expression pattern of vascular endothelial growth factor (VEGF) from soluble to cell-associated isoform during tuMourigenesis[J]. BMC Cancer, 2005, 5(2): 128-134.

West China Medical Journal

Effect of Combined Detection Value of Serum Vascular Endothelial Growth Factor and other Tumor Markers on Early Diagnosis of Lung Cancer

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