【摘要】 目的 探讨脓毒血症患者胆碱酯酶水平与患者病情及预后的关系。 方法 2007年6月-2009年6月，将89例脓毒血症患者设定为脓毒血症组，进行血清胆碱酯酶测定及APACHEⅡ评分；另择82例健康人为正常组，测定血清胆碱酯酶值，比较两者之间差异；89例脓毒症患者按病况再分为存活组及死亡组，比较两者之间血清胆碱酯酶及APACHEⅡ评分差异。 结果 治疗前脓毒血症组胆碱酯酶水平明显低于正常组，有统计学意义（P lt;0.01）；脓毒血症组APACHEⅡ评分与血清胆碱酯酶呈负相关；死亡组APACHEⅡ评分明显高于存活组，而血清胆碱酶低于存活组（P lt;0.01）。 结论 胆碱酯酶同APACHEⅡ评分呈负相关，能明显反映脓毒症患者病情严重程度及预后。
【Abstract】 Objective To explore the relationship between the level of cholinesterase and the patients condition and the prognosis in the patients with sepsis. Methods From June 2007 to June 2009, 89 patients with sepsis were selected as the sepsis group, whose cholinesterase level was assayed and evaluated by APACHE Ⅱ score. Another 82 healthy people were as the control whose cholinesterase level was assayed and compared with that in the sepsis group. The patients in the sepsis group were subdivided into survival and death group; the level of cholinesterase and the result of APACHE Ⅱ score were compared between the two groups. Results The level of cholinesterase in sepsis group was significantly lower than that in the control group before treatment, and the difference was significant (P lt;0.01); the APACHE Ⅱ score negatively correlated with the serum cholinesterase in sepsis group. The APACHE Ⅱ score in the death group was significantly higher than that in the survival group, but the level of cholinesterase was obviously lower in the death group than that in the survival group (P lt;0.01). Conclusion The serumal cholinesterase negatively correlates with the APACHE Ⅱ score, which could obviously reflect the patients condition and the prognosis of sepsis.
Citation：
LI Xiaoyu,MA Hongyuan. Relationship between the Level of Cholinesterase and the Patients Condition and the Prognosis of Sepsis. West China Medical Journal, 2010, 25(11): 2025-2027. doi:
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Copyright © the editorial department of West China Medical Journal of West China Medical Publisher. All rights reserved
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周国鹏, 宋以信, 赵志杰. APACHEⅡ评价系统对75岁以上老年重症病人预后评价价值[J]. 中华内科杂志, 2005, 44(4): 251-252.
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- 1. 朱建一, 闻平. 血清胆碱酯酶和前白蛋白对肝脏合成功能检测的意义[J]. 临床检验杂志, 2004, 22(6): 458.
- 2. 熊军, 薛富善, 廖旭, 等. 血清胆碱酯酶水平对危重症病情判断的意义[J]. 中国呼吸与危重监护杂志, 2009, 6(11): 585-587.
- 3. 卢国浩, 卢一郡, 党超. ICU患者血乳酸/血清胆碱酯酶的比值与 APACHE Ⅱ评分的相关性研究[J]. 湖南中医药大学学报, 2009, 29(10): 22-24.
- 4. 王辰, 朱宇清. 胆碱酯酶在危重症患者病情预判中的应用及与APACHEⅡ的相关性[J]. 医学临床研究, 2010, 27(4): 579-581.
- 5. 王景梅. 血清胆碱酯酶变化与病危程度及愈后预测价值[J]. 中国疗养医学, 2008, 17(9): 549-550.
- 6. Cusack R J, Rholdes A, Lochhead P, et al. The strong ion gap does not have prognos-tic value in cdticauy ill paticats in a mixed medical/sursical adult ICU[J]. Intensive Care Med, 2002, 28(7): 864-869.
- 7. 田惠玉, 齐会卿. 重症脓毒症患者血清胆碱酯酶水平与病情严重程度及预后的联系[J]. 临床荟萃, 2009, 24(6): 526-527.
- 8. 巴立, 张茂, 干建新, 等. 血清胆碱酯酶变化与严重多发伤患者病情及转归的关系[J]. 中华外科杂志, 2007, 45(13): 921-922.
- 9. 邱海波, 周韵霞. 多器官功能障碍综合征现代治疗[M]. 北京: 人民军医出版社, 2001: 518.
- 10. Erbay H, Yalcin AN, Serin S, et al. Nosocomial infections in intensive care unit in a Turkish university hospital: a 2-year survey[J]. Intensive Care Med, 2003, 29(9): 1482-1488.
- 11. 周国鹏, 宋以信, 赵志杰. APACHEⅡ评价系统对75岁以上老年重症病人预后评价价值[J]. 中华内科杂志, 2005, 44(4): 251-252.
- 12. 凌平, 孙大治. APACHEⅡ评分在外科重症监护病房中的应用价值[J]. 重庆医学, 2006, 35(7): 632-634.
