【摘要】 目的 研究两种不同的衰减系数转换方法对正电子发射计算机断层显像/计算机体层扫描（PET/CT） 标准摄取值（SUV）测量值的影响。 方法 2009年11-12月，从经过PET/CT氟代脱氧葡萄糖（FDG）显像患者中选取20例，其口腔中均有金属假牙。以四段转换法和二段转换法重建全身衰减校正断层图像。分别选取3种高密度区域和7种低密度区域，测量其最大SUV和平均SUV，比较两种转换方法SUV测量值。 结果 平均SUV：二段转换法的3种高密度区域SUV降低，在7种低密度区域中，1种区域增高，1种区域降低（P值均 lt;0.05）。最大SUV：二段转换法的2种高密度区域的SUV降低，在7种低密度区域中，1种区域增高，2种靠近高密度组织的区域降低（P值均 lt;0.05）。 结论 二段转换法能降低高密度区域的SUV，可用于减小体内金属植入物和CT对比剂造成的过度校正。
【Abstract】 Objective To explore the effect of two attenuation correction algorithms on PET/CT SUV measurement. Methods From November to December 2009, the PET Slice of 20 patients with metallic dental implant were reconstructed with four-and two-section algorithms respectively. Mean SUV and maximum SUV were measured in three high-density areas and 7 low-density areas. Paired t test were performed to compare the differences. Results Mean SUV: two-section algorithm produced significantly lower SUV in all the three high-density areas; in the 7 low-density areas, SUV increased obviously in one area and decreased apparently in one area (P lt;0.05). Maximum SUV: two-section algorithm produced significantly lower SUV in two high-density areas, SUV increased obviously in one area and decreased apparently in two areas which was adjacent to the high density areas (P lt;0.05). Conclusion Two-section algorithm produces lower SUV measurement value than the four-section algorithm does, and it is useful in PET/CT studies for patients with metallic dental implant and when CT contrast is used.
Citation：
YANG Xiaochuan,ZHOU Lyi. Effect of Different Attenuation Coefficient Transformation Algorithms on PET/CT SUV Measurement. West China Medical Journal, 2010, 25(11): 2052-2054. doi:
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- 1. Kamel EM, Burger C, Buck A, et al. Impact of metallic dental implants on CT-based attenuation correction in a combined PET/CT scanner[J]. Eur Radiol, 2003, 13(4): 724-728.
- 2. Beyer T, Kinahan PE, Townsend DW, et al. The use of X-ray CT for attenuation correction of PET data// In Proceedings of the 1994 IEEE Nuclear Science Symposium and Medical Imaging Conference, Trendler RC[C]. Norfolk, VA, USA, 1994: 1573-1577.
- 3. Kinahan PE, Hasegawa BH, Beyer T. Xray-based attenuation correction for positron emission tomography/computed tomography scanners[J]. Semin Nucl Med, 2003, 33(6): 166-179.
- 4. Kinahan PE, Townsend DW, Beyer T, et al. Attenuation correction for a combined 3D PET/CT scanner[J]. Med Phys, 1998, 25(10): 2046-2053.
- 5. Bai C, Shao L, Da Silva AJ, et al. A generalized model for the conversion from CT numbers to linear attenuation coefficients[J]. IEEE Trans Nucl Sci, 2003, 50(5): 1510-1515.
- 6. Guy MJ, Castellano-Smith IA, Flower MA, et al. DETECT-dual energy transmission estimation CT-for improved attenuation correction in SPECT and PET[J]. IEEE Trans Nucl Sci, 1998(6), 45: 1261-1267.
- 7. Bai C, Tung C, Kolthammer J, et al. CT-based attenuation correction in PET image reconstruction for the Gemini system[J]. IEEE Nuclear Science Symposium Conference Record, 2003, (5): 3082-3086.
- 8. Nakae Y, Sakamoto K, Minamoto T, et al. Clinical evaluation of a newly developed method for avoiding artifacts caused by dental fillings on X-ray CT[J]. Radiol Phys Technol, 2008(1): 115-122.
