Effect of Different Concenitaliors of Soluble Fas，Soluble Fas Ligand and LH in Preovulatory Follicular Fluid on Pregnancy Results in outcome_West China Medical Journal

Authors：

MA Qianhong , LI ShangWei , PENG Zhilan , et al.

West China Second University Hospital，Sichuan University，Chengdu 610041，China;

Corresponding author：

Keywords：

Fas; Fas配体; 体外授精胚胎移植; 促黄体素; 颗粒细胞; 凋亡

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目的：分析体外受精(IVF)患者卵泡液中sFas和sFasL的浓度与妊娠的关系，以及与卵泡液中的促黄体素(LH)水平之间的相关性。方法：收集行IVF/ICSI患者的卵泡液，测定sFas、sFasL和LH浓度。结果：妊娠组排卵前卵泡液中的sFasL和LH水平显著高于未妊娠组(P分别为0.002和＜0.001)，两组中sFas水平没有明显差异。通过logistic回归分析，卵泡液中与妊娠有统计学相关的因素仅为LH，OR=4.117(P为0.001)。卵泡液中的LH和sFasL的水平呈明显正相关关系(P lt;0.001)，LH与sFas之间无显著相关关系。结论：在IVF/ICSI治疗周期中，卵泡液中的sFasL蛋白和LH水平与妊娠结局有关，卵泡液中的LH水平可能通过调节卵泡局部的某些系统来调节卵泡中FasFasL系统介导的凋亡作用。

Citation： MA Qianhong,LI ShangWei,PENG Zhilan,et al.. Effect of Different Concenitaliors of Soluble Fas，Soluble Fas Ligand and LH in Preovulatory Follicular Fluid on Pregnancy Results in outcome. West China Medical Journal, 2009, 24(2): 319-322. doi: Copy

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6.	Cataldo NA，Fujimoto VY，Jaffe RB.Interferongamma and activin A promote insulinlike growth factorbinding protein2 and 4 accumulation by human luteinizing granulosa cells，and interferongamma promotes their apoptosis[J].J Clin Endocrinol Metab，1998，83：179-186..
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8.	Porter DA，Harman RM，Cowan RG，et al.Susceptibility of ovarian granulosa cells to apoptosis differs in cells isolated before or after the preovulatory LH surge[J].Mol Cell Endocrinol，2001，15：13-20..
9.	Westergaard LG，Erb K，Laursen SB，et al.Concentrations of gonadotropins and steroids in preovulatory follicular fluid and serum in relation to stimulation protocol and outcome of assisted reproduction treatment[J].RBMonline，2004，8：516-523..
10.	Slot KA，de BoerBrouwer M，Houweling M et al.Luteinizing hormone inhibits Fasinduced apoptosis in ovarian surface epithelial cell lines[J].J Endocrinol，2006，188：227-239.
11.	Chen Q，Yano T，Matsumi H，et al.Crosstalk between Fas/Fas ligand system and nitric oxide in the pathway subserving granulosa cell apoptosis：a possible regulatory mechanism for ovarian atresia[J].Endocrinology，2005，146：808-815.

1.
2. Srivastava M，Lippes J，Fichorova R，et al.Soluble Fas(sFas)and Soluble Fas ligand(sFasL)in human reproductive tract fluid[M].IN：Processings of the 45th Annual Meeting of the Society for Gynecologic Investigation；Chicago，IL.Abstract T203..
3. de los Santos MJ，Anderson DJ，Racowsky C et al.Presence of FasFas ligand system and Bcl2 gene products in cells and fluids from gonadotropinstimulated human ovaries[J].Biol Reprod，2000，63：1811-1816..
4. 马黔红，李尚为，黄仲英，等.长效促性腺激素释放激素激动剂用于体外受精胚胎移植中降调节后延迟卵巢启动时间的探讨[J].实用妇产科杂志，2006，22：603-606..
5. Kayagaki N，Kawasaki A，Ebata T，et al.Metalloproteinasemediated release of human Fas ligand[J].J Exp Med，1995，192：1777-1783..
6. Cataldo NA，Fujimoto VY，Jaffe RB.Interferongamma and activin A promote insulinlike growth factorbinding protein2 and 4 accumulation by human luteinizing granulosa cells，and interferongamma promotes their apoptosis[J].J Clin Endocrinol Metab，1998，83：179-186..
7. Quirk SM，Cowan RG，Joshi SG，Henrikson KP.Fas antigenmediated apoptosis in human granulosa/luteal cells[J].Biol Reprod，1995，52：279-287..
8. Porter DA，Harman RM，Cowan RG，et al.Susceptibility of ovarian granulosa cells to apoptosis differs in cells isolated before or after the preovulatory LH surge[J].Mol Cell Endocrinol，2001，15：13-20..
9. Westergaard LG，Erb K，Laursen SB，et al.Concentrations of gonadotropins and steroids in preovulatory follicular fluid and serum in relation to stimulation protocol and outcome of assisted reproduction treatment[J].RBMonline，2004，8：516-523..
10. Slot KA，de BoerBrouwer M，Houweling M et al.Luteinizing hormone inhibits Fasinduced apoptosis in ovarian surface epithelial cell lines[J].J Endocrinol，2006，188：227-239.
11. Chen Q，Yano T，Matsumi H，et al.Crosstalk between Fas/Fas ligand system and nitric oxide in the pathway subserving granulosa cell apoptosis：a possible regulatory mechanism for ovarian atresia[J].Endocrinology，2005，146：808-815.

West China Medical Journal

Effect of Different Concenitaliors of Soluble Fas，Soluble Fas Ligand and LH in Preovulatory Follicular Fluid on Pregnancy Results in outcome

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