目的:了解大剂量重组人红细胞生成素(rHuEPO)改善化疗患者相关性贫血并提高其生活质量的情况。方法:44例患者随机分为治疗组和对照组,治疗组:rHuEPO 2×104 U第1～2天,1×104 U第3～10天,ih,同时铁剂力菲能150 mg po,tid,维生素C 100 mg po, tid。对照组:单用铁剂和维生素C,观察治疗前后血红蛋白和生活质量的变化及副反应。护理:加强患者心理护理、合理用药,严密观察病情,及时处理并发症,做好健康指导,以提高益比奥的治疗效果,避免不良反应的发生。结果:治疗组4周后的血红蛋白和红细胞比容分别升高21.0 g·L-1、5.31％,对照组分别下降12.5 g·L-1、3.36％(P lt;0.001);EPO治疗组总有效率为77.3％,而对照组为4.5％,差异有显著性(P lt;0.001);治疗组KPS评分升高,而对照组下降(P lt;0.001);治疗组与对照组在治疗后输血率和输血量相比差异无显著性;EPO副反应少,耐受性好。结论:大剂量EPO治疗肿瘤化疗相关性贫血安全有效,可提高Hb水平,改善生活质量。
Citation：
黄宗琼. 大剂量重组人红细胞生成素改善肿瘤患者化疗后贫血的护理. West China Medical Journal, 2009, 24(4): 1013-1014. doi:
Copy
Copyright © the editorial department of West China Medical Journal of West China Medical Publisher. All rights reserved
| 1. |
GROOPMAN J E. LTRI LM. Chemotherapy-induced anemia in adults:incidence and treatment [J]. J Natl Cancer Inst,1999,91(19):1616..
|
| 2. |
CARO J J, SALAS M, WARD A, et al. Anemia as an independent prognost factor for survival in patients with cancer; a systematic, quantitative review[J]. Cancer,2001,91(12):2214..
|
| 3. |
DEMPKE W, VON POBLOZKI, GROTHEY A, et al. Human hematopoietic growth factors:old lesson and new perspectives[J]. Anticancer Res,2000,20(60):5155..
|
| 4. |
朱江,侯梅,等.宁红欣改善肿瘤患者化疗后贫血的临床研究[J].华西药学杂志,2003,18(4):310..
|
| 5. |
CELLA D, BRON D. The effect of epoet in alfa on quality of life in amemic cancer patients[J]. Cancer Pract,1999,7(40):177..
|
| 6. |
LLUDWIG H, FRITZ E. Anemia in cancer patients[J]. Semin Onol,1998,25(suppl):35.
|
- 1. GROOPMAN J E. LTRI LM. Chemotherapy-induced anemia in adults:incidence and treatment [J]. J Natl Cancer Inst,1999,91(19):1616..
- 2. CARO J J, SALAS M, WARD A, et al. Anemia as an independent prognost factor for survival in patients with cancer; a systematic, quantitative review[J]. Cancer,2001,91(12):2214..
- 3. DEMPKE W, VON POBLOZKI, GROTHEY A, et al. Human hematopoietic growth factors:old lesson and new perspectives[J]. Anticancer Res,2000,20(60):5155..
- 4. 朱江,侯梅,等.宁红欣改善肿瘤患者化疗后贫血的临床研究[J].华西药学杂志,2003,18(4):310..
- 5. CELLA D, BRON D. The effect of epoet in alfa on quality of life in amemic cancer patients[J]. Cancer Pract,1999,7(40):177..
- 6. LLUDWIG H, FRITZ E. Anemia in cancer patients[J]. Semin Onol,1998,25(suppl):35.
