目的:观察蛇伤患者凝血、抗凝和纤溶系统各项指标的变化并探讨其临床意义。方法:以36例蛇伤患者和32例健康体检者为研究对象,测定血浆凝血酶原时间(PT)、部分凝血活酶时间(APTT)、纤维蛋白原(Fg)、血管性血友病因子(vWF)、凝血酶调节蛋白(TM)、组织型纤溶酶原激活物(tPA)、纤溶酶原激活物抑制物1(PAI1)含量。结果:与正常对照组比较,蛇伤患者PT、APTT、vWF、TM、tPA、PAI1水平明显升高,Fg水平明显降低(P lt;001)。结论:蛇伤患者存在凝血、抗凝、纤溶系统的紊乱,早期使用抗蛇毒血清对于防治弥散性血管内凝血(DIC)和多器官功能障碍(MODS)的发生有积极意义。
Citation：
LIU Xiaohui,LIAO Huawei,ZHANG Jie.. The Changes and Significance in Coagulative, Anticoagulant and Fibrinolytic System in SnakeBite Patients. West China Medical Journal, 2009, 24(5): 1163-1164. doi:
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- 2. MARK Rl, F S. Snake venom[J]. Drugs,1997,54(3):110.
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- 5. BORAWSKI J, MYSLIWIEC M. Soluble thrombomodulin: a marker of endothelial injury, an antithrombotic agent, or both[J]. Med Sci Monit,2001,7(4):785786.
- 6. 梁广佳,陈生,王晓忠,等.蛇毒对人体凝血系统的影响[J].江西医学检验,2005,23(6):567568.
- 7. BELL W R. The fibrinolytic system in neoplasia[J]. Semin Thromb Hemost,1996,22(6):459478.
- 8. 刘书元,罗洁珍,冯恒基,等.中西医结合抢救重、危重型毒蛇咬伤体会[J].广东医学,2004,25(9):10991101.
