目的:观察等效剂量瑞芬太尼和芬太尼诱导气管插管对小儿血流动力学的影响。方法:40例择期行全麻患儿随机分为瑞芬太尼组和芬太尼组,麻醉诱导使用咪唑安定0.15mg/kg、丙泊酚2.5mg/kg、芬太尼2.5μg/kg或瑞芬太尼2μg/kg和维库溴铵0.1mg/kg。分别于麻醉诱导前(T0)、诱导后2min(T1)、插管后1、2min(T2、T3)记录心率、收缩压和舒张压。结果:两组诱导前血流动力学指标相似。与T0时比较,两组患儿T1时收缩压、舒张压均降低(P lt;0.05或P lt;0.01),心率均减慢(P lt;0.05或P lt;0.01);瑞芬太尼组T2.T3时收缩压、舒张压降低(P lt;0.05或P lt;0.01),心率减慢(P lt;0.05);芬太尼组T2、T3时收缩压、舒张压升高(P lt;0.05),心率增快(P lt;0.05)。与芬太尼组比较,瑞芬太尼组T1、T2和T3时收缩压、舒张压均降低(P lt;0.05),心率减慢(P lt;0.05)。结论:瑞芬太尼比等效剂量芬太尼能更好地抑制小儿全麻诱导气管插管时的心血管反应。
Citation：
XU Li,WANG Jian,LUO Linli.. Comparison of Remifentanil and Fentanyl during Induction of Pediatric Anaesthesia. West China Medical Journal, 2009, 24(5): 1211-1212. doi:
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