目的 探讨肝脏局灶性结节性增生(FNH)的临床诊断与治疗,以提高对FNH的认识。
方法 回顾性分析我院普通外科2004年7月至2011年7月期间收治的21例经术后病理证实为FNH的临床资料。
结果 本组21例FNH患者中男6例,女15例,平均年龄31.1岁。单发19例,多发2例。9例为体检发现,无不适症状;12例有右上腹隐痛不适症状,均无肝炎、肝硬变病史;1例女性患者有长期口服雌激素病史。化验检查:谷丙转氨酶轻度升高1例,其余肝功能检查、肿瘤标志物及HBsAg均为阴性。术前影像学检查诊断符合率:彩超检查为42.9% (6/14),CT检查为50.0% (6/12),MRI检查为38.5% (5/13)。术后均恢复良好,随访至今无复发。
结论 FNH术前确诊率仍较低,主要依赖术后病理学检查。对于术前诊断不明确、病灶巨大或有临床症状者仍应采取手术切除治疗。
Citation:
贾昌俊,戴朝六,卜献民,彭松林,徐锋,许永庆,赵阳. Diagnosis and Treatment for Hepatic Focal Nodular Hyperplasia (Report of 21 Cases). CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(5): 553-554. doi:
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Bosman FT, Carneiro F, Hruban RH, et al. World Health Organi-zation classification of tumours of the digestive system[M]. 4th ed.lyon:Iarc Press, 2010:198-204.
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陈伶俐, 纪元, 许建芳, 等. 肝脏局灶结节性增生238例临床病理分析[J]. 中华病理学杂志, 2011, 40(1):17-22.
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王征旭, 胡桂芳, 吴孟超. 肝脏局灶性结节增生的诊断和治疗(附21例报告)[J]. 中国普外基础与临床杂志, 2003, 10(2):147-150.
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Kapp N, Curtis KM. Hormonal contraceptive use among women with liver tumors:a systematic review[J]. Contraception, 2009, 80(4):387-390.
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Hussain SM, Terkivatan T, Zondervan PE, et al. Focal nodular hyperplasia:findings at state-of-the-art MR imaging, US, CT, and pathologic analysis[J]. Radiographics, 2004, 24(1):3-17.
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李迎春, 宋彬, 蒋莉莉, 等. 新型MR造影剂钆贝葡胺诊断肝脏局灶性结节样增生的价值(附5例报告)[J]. 中国普外基础与临床杂志, 2007, 14(5):598-604.
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Rahili A, Cai J, Trastour C, et al. Spontaneous rupture andhemorrhage of hepatic focal nodular hyperplasia in lobus caudatus[J]. J Hepatobiliary Pancreat Surg, 2005, 12(2):138-142.
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Langrehr JM, Pfitzmann R, Hermann M, et al. Hepatocellular carcinoma in association with hepatic focal nodular hyperplasia[J]. Acta Radiol, 2006, 47(4):340-344.
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- 1. Bosman FT, Carneiro F, Hruban RH, et al. World Health Organi-zation classification of tumours of the digestive system[M]. 4th ed.lyon:Iarc Press, 2010:198-204.
- 2. 陈伶俐, 纪元, 许建芳, 等. 肝脏局灶结节性增生238例临床病理分析[J]. 中华病理学杂志, 2011, 40(1):17-22.
- 3. 王征旭, 胡桂芳, 吴孟超. 肝脏局灶性结节增生的诊断和治疗(附21例报告)[J]. 中国普外基础与临床杂志, 2003, 10(2):147-150.
- 4. Cong WM, Dong H, Tan L, et al. Surgicopathological classification of hepatic space-occupying lesions:a single-center experience with literature review[J]. World J Gastroenterol, 2011, 17(19):2372-2378.
- 5. Kapp N, Curtis KM. Hormonal contraceptive use among women with liver tumors:a systematic review[J]. Contraception, 2009, 80(4):387-390.
- 6. Hussain SM, Terkivatan T, Zondervan PE, et al. Focal nodular hyperplasia:findings at state-of-the-art MR imaging, US, CT, and pathologic analysis[J]. Radiographics, 2004, 24(1):3-17.
- 7. 李迎春, 宋彬, 蒋莉莉, 等. 新型MR造影剂钆贝葡胺诊断肝脏局灶性结节样增生的价值(附5例报告)[J]. 中国普外基础与临床杂志, 2007, 14(5):598-604.
- 8. Rahili A, Cai J, Trastour C, et al. Spontaneous rupture andhemorrhage of hepatic focal nodular hyperplasia in lobus caudatus[J]. J Hepatobiliary Pancreat Surg, 2005, 12(2):138-142.
- 9. Langrehr JM, Pfitzmann R, Hermann M, et al. Hepatocellular carcinoma in association with hepatic focal nodular hyperplasia[J]. Acta Radiol, 2006, 47(4):340-344.