目的 探讨泡沫硬化剂治疗复发性下肢静脉曲张的临床疗效。
方法 选择我院2011年1月至2012年3月期间23例（26条患肢）复发性下肢静脉曲张的患者，其中男9例，平均年龄58.6岁；女14例，平均年龄53.3岁。静脉曲张复发病史1个月～6年，平均3.2年。对其行超声引导下患肢曲张静脉内注射1%聚桂醇泡沫硬化剂后弹力袜压迫，治疗后3d、3个月超声检测曲张静脉闭合情况及有无深静脉血栓形成，3个月后不定期病房随访。
结果 23例患者均在超声引导下成功行泡沫硬化剂治疗，20例（22条患肢）注射1次，3例（4条患肢）注射2次，每例患者每次平均应用5ml泡沫硬化剂。末次注射结束后3d观察曲张静脉均成功闭合。平均随访6个月，治疗后1周2例出现轻度血栓性浅静脉炎，2周内自行缓解，均无严重并发症发生。治疗后3个月3例（4条患肢）局部复发，复发率15.4%，再次局部泡沫硬化剂治疗后至今未复发。10例（12条患肢）注射部位皮肤出现轻度色素沉着，3个月后减轻，6个月至1年消退。所有患者临床症状得到不同程度的缓解。
结论 泡沫硬化剂治疗复发性下肢静脉曲张近期疗效确切且并发症少。
Citation：
李光华,刘晓晨,李煜庆,豆发福,段建锋,周亚东. Foam Sclerosing Agent in Treatment for Recurrent Varicose Veins of Lower Extremities （23 Cases of Clinical Analysis）. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(11): 1229-1231. doi:
Copy
Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
| 1. |
Royle JP. Recurrent varicose veins[J]. World J Surg， 1986， 10(6)：944-953.
|
| 2. |
Kostas T， Ioannou CV， Touloupakis E， et al. Recurrent varicose veins after surgery：a new appraisal of a common and complex problem in vascular surgery[J]. Eur J Vasc Endovasc Surg， 2004， 27(3)：275-282.
|
| 3. |
Winterborn RJ， Foy C， Earnshaw JJ. Causes of varicose vein recurrence：late results of a randomized controlled trial of stripping the long saphenous vein[J]. J Vasc Surg， 2004， 40(4)：634-639.
|
| 4. |
Bergan J. Sclerotherapy：a truly minimally invasive technique[J]. Perspect Vasc Surg Endovasc Ther， 2008， 20(1)：70-72.
|
| 5. |
Drake LA， Dinehart SM， Goltz RW， et al. Guidelines of care for sclerotherapy treatment of varicose and telangiectatic leg veins[J]. J Am Acad Dermatol， 1996， 34(3)：523-528.
|
| 6. |
van Rij AM， Jiang P， Solomon C， et al. Recurrence after varicose vein surgery：a prospective long-term clinical study with duplex ultrasound scanning and air plethysmography[J]. J Vasc Surg， 2003， 38(5)：935-943.
|
| 7. |
Hartmann K， Klode J， Pfister R， et al. Recurrent varicose veins：sonography-based re-examination of 210 patients 14 years after ligation and saphenous vein stripping[J]. Vasa， 2006， 35(1)：21-26.
|
| 8. |
Rutherford EE， Kianifard B， Cook SJ， et al. Incompetent perforating veins are associated with recurrent varicose veins[J]. Eur J Vasc Endovasc Surg， 2001， 21(5)：458-460.
|
| 9. |
Viani MP， Poggi RV， Pinto A， et al. Re-exploration of the saphenofemoral junction in the treatment of recurrent varicose veins[J]. Int Surg， 1996， 81(4)：382-384.
|
| 10. |
Canonico S， Campitiello F， Lauletta V， et al. Diagnostic and surgical approaches to recurrent varicose veins of lower limbs[J]. Panminerva Med， 1997， 39(4)：287-290.
|
| 11. |
Eklof B， Juhan C. Recurence of varicose veins// Eklof B， Gores JE， Thulesius O， et al， eds. Controversies in Management of Venous Disorders[M]. London：Butterworths， 1989：220-233.
|
| 12. |
Breu FX， Guggenbichler S， Wollmann JC， et al. Duplex ultrasound and efficacy criteria in foam sclerotherapy from the 2nd European Consensus Meeting on Foam Sclerotherapy 2006， Tegernsee， Germany[J]. Vasa， 2008， 37(1)：90-95.
|
| 13. |
Ramelet AA， Kern P， Perrin M. Varicose veins and telangiectasias[M]. Paris：Elsevier SAS， 2004：88-91.
|
| 14. |
Goldman MP， Bergan JJ， Guex JJ. Sclerotherapy：Treatment of Varicose and Telangiectactic Leg Veins[M]. 4th edn. Philadelphia：Mosby Elsevier， 2007：33-36.
|
| 15. |
Scultetus AH， Villavicencio JL， Kao TC， et al. Microthrombectomy reduces postsclerotherapy pigmentation：multicenter randomized trial[J]. J Vasc Surg， 2003， 38(5)：896-903.
|
- 1. Royle JP. Recurrent varicose veins[J]. World J Surg， 1986， 10(6)：944-953.
- 2. Kostas T， Ioannou CV， Touloupakis E， et al. Recurrent varicose veins after surgery：a new appraisal of a common and complex problem in vascular surgery[J]. Eur J Vasc Endovasc Surg， 2004， 27(3)：275-282.
- 3. Winterborn RJ， Foy C， Earnshaw JJ. Causes of varicose vein recurrence：late results of a randomized controlled trial of stripping the long saphenous vein[J]. J Vasc Surg， 2004， 40(4)：634-639.
- 4. Bergan J. Sclerotherapy：a truly minimally invasive technique[J]. Perspect Vasc Surg Endovasc Ther， 2008， 20(1)：70-72.
- 5. Drake LA， Dinehart SM， Goltz RW， et al. Guidelines of care for sclerotherapy treatment of varicose and telangiectatic leg veins[J]. J Am Acad Dermatol， 1996， 34(3)：523-528.
- 6. van Rij AM， Jiang P， Solomon C， et al. Recurrence after varicose vein surgery：a prospective long-term clinical study with duplex ultrasound scanning and air plethysmography[J]. J Vasc Surg， 2003， 38(5)：935-943.
- 7. Hartmann K， Klode J， Pfister R， et al. Recurrent varicose veins：sonography-based re-examination of 210 patients 14 years after ligation and saphenous vein stripping[J]. Vasa， 2006， 35(1)：21-26.
- 8. Rutherford EE， Kianifard B， Cook SJ， et al. Incompetent perforating veins are associated with recurrent varicose veins[J]. Eur J Vasc Endovasc Surg， 2001， 21(5)：458-460.
- 9. Viani MP， Poggi RV， Pinto A， et al. Re-exploration of the saphenofemoral junction in the treatment of recurrent varicose veins[J]. Int Surg， 1996， 81(4)：382-384.
- 10. Canonico S， Campitiello F， Lauletta V， et al. Diagnostic and surgical approaches to recurrent varicose veins of lower limbs[J]. Panminerva Med， 1997， 39(4)：287-290.
- 11. Eklof B， Juhan C. Recurence of varicose veins// Eklof B， Gores JE， Thulesius O， et al， eds. Controversies in Management of Venous Disorders[M]. London：Butterworths， 1989：220-233.
- 12. Breu FX， Guggenbichler S， Wollmann JC， et al. Duplex ultrasound and efficacy criteria in foam sclerotherapy from the 2nd European Consensus Meeting on Foam Sclerotherapy 2006， Tegernsee， Germany[J]. Vasa， 2008， 37(1)：90-95.
- 13. Ramelet AA， Kern P， Perrin M. Varicose veins and telangiectasias[M]. Paris：Elsevier SAS， 2004：88-91.
- 14. Goldman MP， Bergan JJ， Guex JJ. Sclerotherapy：Treatment of Varicose and Telangiectactic Leg Veins[M]. 4th edn. Philadelphia：Mosby Elsevier， 2007：33-36.
- 15. Scultetus AH， Villavicencio JL， Kao TC， et al. Microthrombectomy reduces postsclerotherapy pigmentation：multicenter randomized trial[J]. J Vasc Surg， 2003， 38(5)：896-903.
