Efficacy of Triclosan-Coated Polyglactin 910 Suture in Reducing Surgical Wound Infection for Patients Undergoing Gastrointestinal Emergency Operation_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WEN Kunming , ZENG Qingliang , FENG Guoli , HUANG Handong.

Department of Gastrointestinal Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, Guizhou Province, China;

Corresponding author：

Keywords：

Triclosan-coated polyglactin 910 suture; Gastrointestine; Emergency operation; Surgical wound infection

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

ObjectiveTo evaluate the role of triclosan-coated polyglactin 910 suture in reducing wound infections of emergency gastrointestinal surgeries. MethodsThis was a prospective, randomized, controlled, single center study. From May 2009 to August 2010, 412 patients underwent emergency gastrointestinal operations in our department, 198 of them were chose randomly as experimental group using triclosancoated polyglactin 910 suture for abdominal wall closure， 214 using traditional braiding suture were taken as control. The risk factors for wound healing were analyzed, and wound infection rate was compared between two groups. ResultsThere were no significant differences of gender, age, body mass index, combined diabetes, use of immunosuppressant, and glucocorticoid steroid, type of incision, intraoperative bleeding volume, and operation time between two groups (P gt;0.05). Wound infection rate of experimental group 〔3.0% (6/198）〕 was significantly lower than that of control group 〔11.7% (25/214), P lt;0.001〕. Especially in subgroup of type Ⅲ incision and operative time more than 120 min, wound infection rate was significantly different between experimental group and control group 〔3.5%(5/141) versus 14.3%(22/154); 3.3%(2/60) versus 21.2%(11/52) respectively, P lt;0.001〕. ConclusionTriclosancoated polyglactin 910 suture can reduce wound infection rate of gastrointestinal emergency operations, especially with type Ⅲ incision and operation time ≥120 min.

Citation： WEN Kunming,ZENG Qingliang,FENG Guoli,HUANG Handong.. Efficacy of Triclosan-Coated Polyglactin 910 Suture in Reducing Surgical Wound Infection for Patients Undergoing Gastrointestinal Emergency Operation. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(9): 969-972. doi: Copy

1.	Engemann JJ, Carmeli Y, Cosgrove SE, et al. Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infection [J]. Clin Infect Dis, 2003, 36(5): 592598.
2.	Zhan C, Miller MR. Excess length of stay, charges, and mortality attributable to medical injuries during hospitalization [J]. JAMA, 2003, 290(14): 18681874.
3.	Dimick JB, Chen SL, Taheri PA, et al. Hospital costs associated with surgical complications: a report from the privatesector National Surgical Quality Improvement Program [J]. J Am Coll Surg, 2004, 199(4): 531537.
4.	Justinger C, Moussavian MR, Schlueter C, et al. Antibacterial [corrected] coating of abdominal closure sutures and wound infection [J]. Surgery, 2009, 145(3): 330334.
5.	GómezAlonso A, GarcíaCriado FJ, ParreoManchado FC, et al. Study of the efficacy of Coated VICRYL Plus Antibacterial suture (coated Polyglactin 910 suture with Triclosan) in two animal models of general surgery [J]. J Infect, 2007, 54(1): 8288.
6.	李景春, 宋立伟, 王彩平. 预防穿孔性阑尾炎切口感染的两点改进 [J]. 中国普外基础与临床杂志, 2008, 15(1): 26.
7.	Edmiston CE, Seabrook GR, Goheen MP, et al. Bacterial adherence to surgical sutures: can antibacterialcoated sutures reduce the risk of microbial contamination? [J]. J Am Coll Surg, 2006, 203(4): 481489.
8.	Jones RD, Jampani HB, Newman JL, et al. Triclosan: a review of effectiveness and safety in health care settings [J]. Am J Infect Control, 2000, 28(2): 184196.
9.	Fiss EM, Rule KL, Vikesland PJ. Formation of chloroform and other chlorinated byproducts by chlorination of triclosancontaining antibacterial products [J]. Environ Sci Technol, 2007, 41(7): 23872394.
10.	Barbolt TA. Chemistry and safety of triclosan, and its use as an antimicrobial coating on Coated VICRYL* Plus Antibacterial Suture (coated polyglactin 910 suture with triclosan) [J]. Surg Infect (Larchmt), 2002, 3 Suppl 1: S45S53.
11.	Rothenburger S, Spangler D, Bhende S, et al. In vitro antimicrobial evaluation of Coated VICRYL* Plus Antibacterial Suture (coated polyglactin 910 with triclosan) using zone of inhibition assays [J]. Surg Infect (Larchmt), 2002, 3 Suppl 1: S79S87.
12.	Ford HR, Jones P, Gaines B, et al. Intraoperative handling and wound healing: controlled clinical trial comparing coated VICRYL plus antibacterial suture (coated polyglactin 910 suture with triclosan) with coated VICRYL suture (coated polyglactin 910 suture) [J]. Surg Infect (Larchmt), 2005, 6(3): 313321.
13.	Storch ML, Rothenburger SJ, Jacinto G. Experimental efficacy study of coated VICRYL plus antibacterial suture in guinea pigs challenged with Staphylococcus aureus [J]. Surg Infect (Larchmt), 2004, 5(3): 281288.
14.	中华人民共和国卫生部. 医院感染诊断标准 [M]. 北京: 中华人民共和国卫生部, 2001: 1012.
15.	王秀茹. 预防医学微生物学及检验技术 [M]. 北京: 人民卫生出版社, 2002: 11371138.
16.	雷泽华, 张道宝, 俞慎林. 外科手术切口感染的危险因素分析及其预防 [J]. 现代预防医学, 2010, 37(4): 789791.
17.	肖汉强, 黄秀良. 外科手术切口感染监测分析与控制 [J]. 中华医院感染学杂志, 2010, 20(2): 204206.
18.	覃忠卫. 普通外科手术切口感染相关因素Logistic回归分析 [J]. 中华医院感染学杂志, 2009, 19(23): 32003201.
19.	郭志晨, 叶竹梅, 黄樟生, 等. 外科腹部手术后切口感染的危险因素 [J]. 中华医院感染学杂志, 2006, 16(7): 761762.
20.	Franchi M, Ghezzi F, BenedettiPanici PL, et al. A multicentre collaborative study on the use of cold scalpel and electrocautery for midline abdominal incision [J]. Am J Surg, 2001, 181(2): 128132.
21.	Israelsson LA, Jonsson T, Knutsson A. Suture technique and wound healing in midline laparotomy incisions [J]. Eur J Surg, 1996, 162(8): 605609.
22.	张林, 曹永宽, 张国虎, 等. 腹膜外放置U型乳胶引流条在控制胃肠手术切口感染中的应用研究 [J]. 中国普外基础与临床杂志, 2009, 16(11): 925927.
23.	王红梅, 张梅. 普通外科手术切口感染调查与分析 [J] . 中国感染控制杂志, 2007, 6(1): 3334.
24.	丁杰, 张忠民, 潘扬, 等. 普通外科切口感染危险因素分析 [J]. 中华医院感染学杂志, 2009, 19(16): 21062108.

1. Engemann JJ, Carmeli Y, Cosgrove SE, et al. Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infection [J]. Clin Infect Dis, 2003, 36(5): 592598.
2. Zhan C, Miller MR. Excess length of stay, charges, and mortality attributable to medical injuries during hospitalization [J]. JAMA, 2003, 290(14): 18681874.
3. Dimick JB, Chen SL, Taheri PA, et al. Hospital costs associated with surgical complications: a report from the privatesector National Surgical Quality Improvement Program [J]. J Am Coll Surg, 2004, 199(4): 531537.
4. Justinger C, Moussavian MR, Schlueter C, et al. Antibacterial [corrected] coating of abdominal closure sutures and wound infection [J]. Surgery, 2009, 145(3): 330334.
5. GómezAlonso A, GarcíaCriado FJ, ParreoManchado FC, et al. Study of the efficacy of Coated VICRYL Plus Antibacterial suture (coated Polyglactin 910 suture with Triclosan) in two animal models of general surgery [J]. J Infect, 2007, 54(1): 8288.
6. 李景春, 宋立伟, 王彩平. 预防穿孔性阑尾炎切口感染的两点改进 [J]. 中国普外基础与临床杂志, 2008, 15(1): 26.
7. Edmiston CE, Seabrook GR, Goheen MP, et al. Bacterial adherence to surgical sutures: can antibacterialcoated sutures reduce the risk of microbial contamination? [J]. J Am Coll Surg, 2006, 203(4): 481489.
8. Jones RD, Jampani HB, Newman JL, et al. Triclosan: a review of effectiveness and safety in health care settings [J]. Am J Infect Control, 2000, 28(2): 184196.
9. Fiss EM, Rule KL, Vikesland PJ. Formation of chloroform and other chlorinated byproducts by chlorination of triclosancontaining antibacterial products [J]. Environ Sci Technol, 2007, 41(7): 23872394.
10. Barbolt TA. Chemistry and safety of triclosan, and its use as an antimicrobial coating on Coated VICRYL* Plus Antibacterial Suture (coated polyglactin 910 suture with triclosan) [J]. Surg Infect (Larchmt), 2002, 3 Suppl 1: S45S53.
11. Rothenburger S, Spangler D, Bhende S, et al. In vitro antimicrobial evaluation of Coated VICRYL* Plus Antibacterial Suture (coated polyglactin 910 with triclosan) using zone of inhibition assays [J]. Surg Infect (Larchmt), 2002, 3 Suppl 1: S79S87.
12. Ford HR, Jones P, Gaines B, et al. Intraoperative handling and wound healing: controlled clinical trial comparing coated VICRYL plus antibacterial suture (coated polyglactin 910 suture with triclosan) with coated VICRYL suture (coated polyglactin 910 suture) [J]. Surg Infect (Larchmt), 2005, 6(3): 313321.
13. Storch ML, Rothenburger SJ, Jacinto G. Experimental efficacy study of coated VICRYL plus antibacterial suture in guinea pigs challenged with Staphylococcus aureus [J]. Surg Infect (Larchmt), 2004, 5(3): 281288.
14. 中华人民共和国卫生部. 医院感染诊断标准 [M]. 北京: 中华人民共和国卫生部, 2001: 1012.
15. 王秀茹. 预防医学微生物学及检验技术 [M]. 北京: 人民卫生出版社, 2002: 11371138.
16. 雷泽华, 张道宝, 俞慎林. 外科手术切口感染的危险因素分析及其预防 [J]. 现代预防医学, 2010, 37(4): 789791.
17. 肖汉强, 黄秀良. 外科手术切口感染监测分析与控制 [J]. 中华医院感染学杂志, 2010, 20(2): 204206.
18. 覃忠卫. 普通外科手术切口感染相关因素Logistic回归分析 [J]. 中华医院感染学杂志, 2009, 19(23): 32003201.
19. 郭志晨, 叶竹梅, 黄樟生, 等. 外科腹部手术后切口感染的危险因素 [J]. 中华医院感染学杂志, 2006, 16(7): 761762.
20. Franchi M, Ghezzi F, BenedettiPanici PL, et al. A multicentre collaborative study on the use of cold scalpel and electrocautery for midline abdominal incision [J]. Am J Surg, 2001, 181(2): 128132.
21. Israelsson LA, Jonsson T, Knutsson A. Suture technique and wound healing in midline laparotomy incisions [J]. Eur J Surg, 1996, 162(8): 605609.
22. 张林, 曹永宽, 张国虎, 等. 腹膜外放置U型乳胶引流条在控制胃肠手术切口感染中的应用研究 [J]. 中国普外基础与临床杂志, 2009, 16(11): 925927.
23. 王红梅, 张梅. 普通外科手术切口感染调查与分析 [J] . 中国感染控制杂志, 2007, 6(1): 3334.
24. 丁杰, 张忠民, 潘扬, 等. 普通外科切口感染危险因素分析 [J]. 中华医院感染学杂志, 2009, 19(16): 21062108.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Efficacy of Triclosan-Coated Polyglactin 910 Suture in Reducing Surgical Wound Infection for Patients Undergoing Gastrointestinal Emergency Operation

Abstract Full text Figures/Tables Video References Cited by

Format

Content