A Brief Analysis of Formation Mechanism and Related Issues of Psammoma Body in Human Tumors ._CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI Xiaolong ^1,2 , LI Zhihui ¹

1.Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;;
2.West China College of Stomatology, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

砂粒体; 钙化; 甲状腺乳头状癌; 脑膜瘤; 卵巢浆液性乳头状癌

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Objective To understand the latest research developments of the formation mechanism of psammoma body in human tumors and related issues. Methods Related domestic and foreign literatures were widely referred, analyzed, and reviewed. Results Psammoma body is unique pathological calcification in some tumors, which is arranged in concentric, laminar circles microscopically. Psammoma body is commonly seen in thyroid papillary carcinoma, meningiomas, ovarian serous papillary carcinoma, and so on. Conclusions Although arranged in concentric, laminar circles microscopically in tumor, the formation process of psammoma body is not entirely the same in different tumors. A comprehensive and objective understanding of psammoma body would be useful in cancer diagnosis and treatment.

Citation： LI Xiaolong,LI Zhihui. A Brief Analysis of Formation Mechanism and Related Issues of Psammoma Body in Human Tumors .. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(11): 1216-1218. doi: Copy

1.	Das DK. Psammoma body: a product of dystrophic calcification or of a biologically active process that aims at limiting the growth and spread of tumor? [J]. Diagn Cytopathol, 2009; 37(7): 534-541.
2.	Gonzalez JE, Caldwell RG, Valaitis J. Calcium oxalate cry-stals in the breast. Pathology and significance [J]. Am J Surg Pathol, 1991; 15(6): 586-591.
3.	Frappart L, Boudeulle M, Boumendil J, et al. Structure and composition of microcalcifications in benign and malignant lesions of the breast: study by light microscopy, transmission and scanning electron microscopy, microprobe analysis, and X-ray diffraction [J]. Hum Pathol, 1984; 15(9): 880-889.
4.	Lanyi M. Microcalcifications in the breast-a blessing or a curse? A critical review [J]. Diagn Imaging Clin Med, 1985; 54(3-4): 126-145.
5.	Fandos-Morera A, Prats-Esteve M, Tura-Soteras JM, et al. Breast tumors: composition of microcalcifications [J]. Radiology, 1988; 169(2): 325-327.
6.	官青, 吴毅. 砂粒体在甲状腺癌研究中的进展 [J]. 中国癌症杂志， 2009； 19(8): 637-640.
7.	Fadare O, Chacho MS, Parkash V. Psammoma bodies in cervicovaginal smears: significance and practical implications for diagnostic cytopathology [J]. Adv Anat Pathol, 2004; 11(5): 250-261.
8.	Kubota T, Hirano A, Sato K, et al. Fine structure of psammoma bodies at the outer aspect of blood vessels in meningioma [J]. Acta Neuropathol, 1985; 66(2): 163-166.
9.	陈昊. 砂粒体在肿瘤中的形成与临床意义 [J]. 河南肿瘤学杂志, 1999； 12(2): 148-149.
10.	Johannessen JV, Sobrinho-Simes M. The origin and significance of thyroid psammoma bodies [J]. Lab Invest, 1980; 43(3): 287-296.
11.	Cameron RI, McCluggage WG. Extensive psammomatous calcification of the uterus and cervix associated with a uterine serous carcinoma [J]. J Clin Pathol, 2004; 57(8): 888-890.
12.	Das DK, Sheikh ZA, George SS, et al. Papillary thyroid carcinoma: evidence for intracytoplasmic formation of precursor substance for calcification and its release from well-preserved neoplastic cells [J]. Diagn Cytopathol, 2008; 36(11): 809-812.
13.	范自平, 乔智, 吴德敬. 甲状腺癌诊断及复发因素分析 [J]. 中国普外基础与临床杂志, 2010； 17(1): 68-72.
14.	Cotran RS, Kumar V, Collins T. Robbins pathologic basis of disease [M]. 6th ed. Noida, India: Harcourt Asia Pte, Ltd, 1999: 43-45, 1143-1144.
15.	Hosoya T, Sakamoto A, Kasai N, et al. Nodal psammoma body in thyroid cancer as an indicator of cancer metastasis to the lymph node [J]. Gan No Rinsho, 1983; 29(11): 1336-1339.
16.	Klinck GH, Winship T. Psammoma bodies and thyroid cancer [J]. Cancer, 1959; 12(4): 656-662.
17.	赵文雯, 王长秋, 鲁安怀，等. 甲状腺乳头状癌中砂粒体矿物学研究 [J]. 岩石矿物学杂志, 2009； 28(6): 623-628.
18.	Bai Y, Zhou G, Nakamura M, et al. Survival impact of psammoma body, stromal calcification, and bone formation in papillary thyroid carcinoma [J]. Mod Pathol, 2009; 22(7): 887-894.
19.	唐波, 姜军. RET原癌基因与分化性甲状腺癌关系的研究进展 [J]. 中国普外基础与临床杂志, 2004； 11(1): 89-91.
20.	Adeniran AJ, Zhu Z, Gandhi M, et al. Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas [J]. Am J Surg Pathol, 2006; 30(2): 216-222.
21.	Smith JH. Psammoma bodies in cervical smears: sifting the grains of sand [J]. Cytopathology, 2007; 18(3): 140-142.
22.	杨若晨, 王长秋, 鲁安怀, 等. 脑膜瘤中砂粒体矿化研究 [J]. 地学前缘, 2008； 15(06): 44-53.
23.	Han J, Daniel JC, Pappas GD. Expression of type Ⅵcollagen in psammoma bodies: immunofluorescence studies on two fresh human meningiomas [J]. Acta Cytol, 1996; 40(2): 177-181.
24.	Kubota T, Yamashima T, Hasegawa M, et al. Formation of psammoma bodies in meningocytic whorls. Ultrastructural study and analysis of calcified material [J]. Acta Neuropathol, 1986; 70(3-4): 262-268.
25.	金晓明, 冈田英吉, 赵纲, 等. 人脑脉络丛内砂粒体的免疫组织化学研究 [J]. 临床与实验病理学杂志, 1999； 15(1): 44-46.
26.	Tunio GM, Hirota S, Nomura S, et al. Possible relation of osteopontin to development of psammoma bodies in human papillary thyroid cancer [J]. Arch Pathol Lab Med, 1998; 122(12): 1087-1090.
27.	Miettinen M, Paetau A. Mapping of the keratin polypeptides in meningiomas of different types: an immunohistochemical analysis of 463 cases [J]. Hum Pathol, 2002; 33(6): 590-598.
28.	Kumar V， Cotran RS, Robbins SL. Robbins basic pathology [M]. 7th ed. Philadelphia: Saunders, 2003: 657-717.
29.	Rosai J. Rosai and Ackerma’s surgical pathology [M]. 9th ed. Edinburgh: Mosby, 2004: 1483-1761.
30.	Tavassoli FA, Devilee P. Pathology and genetics of tumors of the breast and female genital organs [M]. lyon: IARC Press, 2003: 117-287.
31.	Aure JC, Hoeg K, Kolstad P. Psammoma bodies in serous carcinoma of the ovary. A prognostic study [J]. Am J Obstet Gynecol, 1971; 109(1): 113-118.
32.	Sorbe B, Frankendal B. Prognostic importance of psammoma bodies in adenocarcinomas of the ovaries [J]. Gynecol Oncol, 1982; 14(1): 6-14.
33.	王长秋, 杨若晨, 鲁安怀，等. 人体卵巢癌中砂粒体矿化的矿物学研究 [J]. 岩石矿物学杂志, 2009； 28(6): 617-622.
34.	Kiyozuka Y, Nakagawa H, Senzaki H, et al. Bone morphogenetic protein-2 and type Ⅳ collagen expression in psammoma body forming ovarian cancer [J]. Anticancer Res, 2001; 21(3B): 1723-1730.
35.	Tsuchida T, Matsumoto M, Shirayama Y, et al. Observation of psammoma bodies in cultured meningiomas: analysis of three-dimensional structure using scanning and transmission electron microscopy [J]. Ultrastruct Pathol, 1996; 20(3): 241-247.
36.	Das DK, Mallik MK, Haji BE, et al. Psammoma body and its precursors in papillary thyroid carcinoma: a study by fine-needle aspiration cytology [J]. Diagn Cytopathol, 2004; 31(6): 380-386.

1. Das DK. Psammoma body: a product of dystrophic calcification or of a biologically active process that aims at limiting the growth and spread of tumor? [J]. Diagn Cytopathol, 2009; 37(7): 534-541.
2. Gonzalez JE, Caldwell RG, Valaitis J. Calcium oxalate cry-stals in the breast. Pathology and significance [J]. Am J Surg Pathol, 1991; 15(6): 586-591.
3. Frappart L, Boudeulle M, Boumendil J, et al. Structure and composition of microcalcifications in benign and malignant lesions of the breast: study by light microscopy, transmission and scanning electron microscopy, microprobe analysis, and X-ray diffraction [J]. Hum Pathol, 1984; 15(9): 880-889.
4. Lanyi M. Microcalcifications in the breast-a blessing or a curse? A critical review [J]. Diagn Imaging Clin Med, 1985; 54(3-4): 126-145.
5. Fandos-Morera A, Prats-Esteve M, Tura-Soteras JM, et al. Breast tumors: composition of microcalcifications [J]. Radiology, 1988; 169(2): 325-327.
6. 官青, 吴毅. 砂粒体在甲状腺癌研究中的进展 [J]. 中国癌症杂志， 2009； 19(8): 637-640.
7. Fadare O, Chacho MS, Parkash V. Psammoma bodies in cervicovaginal smears: significance and practical implications for diagnostic cytopathology [J]. Adv Anat Pathol, 2004; 11(5): 250-261.
8. Kubota T, Hirano A, Sato K, et al. Fine structure of psammoma bodies at the outer aspect of blood vessels in meningioma [J]. Acta Neuropathol, 1985; 66(2): 163-166.
9. 陈昊. 砂粒体在肿瘤中的形成与临床意义 [J]. 河南肿瘤学杂志, 1999； 12(2): 148-149.
10. Johannessen JV, Sobrinho-Simes M. The origin and significance of thyroid psammoma bodies [J]. Lab Invest, 1980; 43(3): 287-296.
11. Cameron RI, McCluggage WG. Extensive psammomatous calcification of the uterus and cervix associated with a uterine serous carcinoma [J]. J Clin Pathol, 2004; 57(8): 888-890.
12. Das DK, Sheikh ZA, George SS, et al. Papillary thyroid carcinoma: evidence for intracytoplasmic formation of precursor substance for calcification and its release from well-preserved neoplastic cells [J]. Diagn Cytopathol, 2008; 36(11): 809-812.
13. 范自平, 乔智, 吴德敬. 甲状腺癌诊断及复发因素分析 [J]. 中国普外基础与临床杂志, 2010； 17(1): 68-72.
14. Cotran RS, Kumar V, Collins T. Robbins pathologic basis of disease [M]. 6th ed. Noida, India: Harcourt Asia Pte, Ltd, 1999: 43-45, 1143-1144.
15. Hosoya T, Sakamoto A, Kasai N, et al. Nodal psammoma body in thyroid cancer as an indicator of cancer metastasis to the lymph node [J]. Gan No Rinsho, 1983; 29(11): 1336-1339.
16. Klinck GH, Winship T. Psammoma bodies and thyroid cancer [J]. Cancer, 1959; 12(4): 656-662.
17. 赵文雯, 王长秋, 鲁安怀，等. 甲状腺乳头状癌中砂粒体矿物学研究 [J]. 岩石矿物学杂志, 2009； 28(6): 623-628.
18. Bai Y, Zhou G, Nakamura M, et al. Survival impact of psammoma body, stromal calcification, and bone formation in papillary thyroid carcinoma [J]. Mod Pathol, 2009; 22(7): 887-894.
19. 唐波, 姜军. RET原癌基因与分化性甲状腺癌关系的研究进展 [J]. 中国普外基础与临床杂志, 2004； 11(1): 89-91.
20. Adeniran AJ, Zhu Z, Gandhi M, et al. Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas [J]. Am J Surg Pathol, 2006; 30(2): 216-222.
21. Smith JH. Psammoma bodies in cervical smears: sifting the grains of sand [J]. Cytopathology, 2007; 18(3): 140-142.
22. 杨若晨, 王长秋, 鲁安怀, 等. 脑膜瘤中砂粒体矿化研究 [J]. 地学前缘, 2008； 15(06): 44-53.
23. Han J, Daniel JC, Pappas GD. Expression of type Ⅵcollagen in psammoma bodies: immunofluorescence studies on two fresh human meningiomas [J]. Acta Cytol, 1996; 40(2): 177-181.
24. Kubota T, Yamashima T, Hasegawa M, et al. Formation of psammoma bodies in meningocytic whorls. Ultrastructural study and analysis of calcified material [J]. Acta Neuropathol, 1986; 70(3-4): 262-268.
25. 金晓明, 冈田英吉, 赵纲, 等. 人脑脉络丛内砂粒体的免疫组织化学研究 [J]. 临床与实验病理学杂志, 1999； 15(1): 44-46.
26. Tunio GM, Hirota S, Nomura S, et al. Possible relation of osteopontin to development of psammoma bodies in human papillary thyroid cancer [J]. Arch Pathol Lab Med, 1998; 122(12): 1087-1090.
27. Miettinen M, Paetau A. Mapping of the keratin polypeptides in meningiomas of different types: an immunohistochemical analysis of 463 cases [J]. Hum Pathol, 2002; 33(6): 590-598.
28. Kumar V， Cotran RS, Robbins SL. Robbins basic pathology [M]. 7th ed. Philadelphia: Saunders, 2003: 657-717.
29. Rosai J. Rosai and Ackerma’s surgical pathology [M]. 9th ed. Edinburgh: Mosby, 2004: 1483-1761.
30. Tavassoli FA, Devilee P. Pathology and genetics of tumors of the breast and female genital organs [M]. lyon: IARC Press, 2003: 117-287.
31. Aure JC, Hoeg K, Kolstad P. Psammoma bodies in serous carcinoma of the ovary. A prognostic study [J]. Am J Obstet Gynecol, 1971; 109(1): 113-118.
32. Sorbe B, Frankendal B. Prognostic importance of psammoma bodies in adenocarcinomas of the ovaries [J]. Gynecol Oncol, 1982; 14(1): 6-14.
33. 王长秋, 杨若晨, 鲁安怀，等. 人体卵巢癌中砂粒体矿化的矿物学研究 [J]. 岩石矿物学杂志, 2009； 28(6): 617-622.
34. Kiyozuka Y, Nakagawa H, Senzaki H, et al. Bone morphogenetic protein-2 and type Ⅳ collagen expression in psammoma body forming ovarian cancer [J]. Anticancer Res, 2001; 21(3B): 1723-1730.
35. Tsuchida T, Matsumoto M, Shirayama Y, et al. Observation of psammoma bodies in cultured meningiomas: analysis of three-dimensional structure using scanning and transmission electron microscopy [J]. Ultrastruct Pathol, 1996; 20(3): 241-247.
36. Das DK, Mallik MK, Haji BE, et al. Psammoma body and its precursors in papillary thyroid carcinoma: a study by fine-needle aspiration cytology [J]. Diagn Cytopathol, 2004; 31(6): 380-386.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

A Brief Analysis of Formation Mechanism and Related Issues of Psammoma Body in Human Tumors .

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