Advancement of Gene Diagnosis and Gene Therapy on Gastric Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

SHEN Zhiyong , LIU Hua , CAO Hui

Department of General Surgery, Renji Hospital Affiliated to Medical College, Shanghai Jiaotong University, Shanghai 200127, China;

Corresponding author：

Keywords：

Gastric cancer; Gene diagnosis; Gene therapy; DNA methylation; Mismatch repair gene; Oncogene

Video：

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Objective To review the advance of gene diagnosis and gene therapy on gastric cancer. Methods Literatures about the advance of gene diagnosis and therapy on gastric cancer were reviewed. Results Detection of tumor marker by gene technique is important for early diagnosis, follow-up and therapy evaluation of gastric cancer in clinic. But there are still many problems in gene therapy of gastric cancer. Conclusion Gene detection and gene therapy will become important supplementary means for diagnosis and treatment of gastric cancer.

Citation： SHEN Zhiyong,LIU Hua,CAO Hui. Advancement of Gene Diagnosis and Gene Therapy on Gastric Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2009, 16(6): 500-502. doi: Copy

1.	杨少辉, 戴冬秋. 肿瘤抑制基因甲基化与胃癌 [Ｊ]. 中国普外基础与临床杂志, 2006; 13(5): 614-616.
2.	黄斌, 李昂, 张波, 等. 纳米炭吸附5-FU淋巴靶向化疗对胃癌组织及转移淋巴结bcl-2、bax及caspase-3表达的影响 [Ｊ]. 中国普外基础与临床杂志, 2009; 16(1): 18-22.
3.	Deng D, El-Rifai W, Ji J, et al. Hypermethylation of metallothionein-3 CpG island in gastric carcinoma [Ｊ]. Carcinogenesis, 2003; 24(1): 25-29.
4.	Tanaka H, Yashiro M, Sunami T, et al. ICAM-2 gene therapy for peritoneal dissemination of scirrhous gastric carcinoma [Ｊ]. Clin Cancer Res, 2004; 10(14): 4885-4892.
5.	Carneiro F, Oliveira C, Leite M, et al. Molecular targets and biological modifiers in gastric cancer [Ｊ]. Semin Diagn Pathol, 2008; 25(4): 274-287.
6.	Ficorella C, Cannita K, Ricevuto E, et al. P16 hypermethylation contributes to the characterization of gene inactivation profiles in primary gastric cancer [Ｊ]. Oncol Rep, 2003; 10(1): 169-173.
7.	Jones PA, Takai D. The role of DNA methylation in mammalian epigenetics [Ｊ]. Science, 2001; 293(5532): 1068-1070.
8.	Leung WK, Yu J, Ng EK, et al. Concurrent hypermethylation of multiple tumor-related genes in gastric carcinoma and adjacent normal tissues [Ｊ]. Cancer, 2001; 91(12): 2294-2301.
9.	温爽, 刘天卿, 李梅, 等. 胃黏膜上皮错配修复基因hMLH1表达在胃癌诊断中的临床意义 [Ｊ]. 大连医科大学学报, 2007; 29 (6): 539-541.
10.	Schimmer AD. Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice [Ｊ]. Cancer Res, 2004; 64(20): 7183-7190.
11.	Altieri DC. The molecular basis and potential role of survivin in cancer diagnosis and therapy [Ｊ]. Trends Mol Med, 2001; 7(12): 542-547.
12.	何满西, 李耿, 姚有贵, 等. 胰腺癌细胞survivin表达RNAi抑制载体的构建及其抑制作用的研究 [Ｊ]. 中国普外基础与临床杂志, 2008; 15(11)： 829-834.
13.	张成斌, 燕善军, 王启之, 等. survivin基因检测在胃癌辅助诊断中的应用 [Ｊ]. 蚌埠医学院学报, 2007; 32(6): 649-652.
14.	刘平, 王同杉, 游思洪, 等. livin在人胃癌组织中的表达及其沉默后对胃癌细胞凋亡的影响 [Ｊ]. 中华肿瘤杂志, 2007; 29(8): 570-574.
15.	李中福, 王子卫. 胃癌组织中Livin的表达及意义 [Ｊ]. 中华消化外科杂志, 2008; 7(3): 177-179.
16.	Nishimura T. Total number of genome alterations in sporadic gastrointestinal cancer inferred from pooled analyses in the literature [Ｊ]. Tumour Biol, 2008; 29(6): 343-350.
17.	Wen SF, Xie L, McDonald M, et al. Development and validation of sensitive assays to quantitate gene expression after p53 gene therapy and paclitaxel chemotherapy using in vivo dosing in tumor xenograft models [Ｊ]. Cancer Gene Ther, 2000; 7(11): 1469-1480.
18.	Ohashi M, Kanai F, Ueno H, et al. Adenovirus mediated p53 tumour suppressor gene therapy for human gastric cancer cells in vitro and in vivo [Ｊ]. Gut, 1999; 44(3): 366-371.
19.	Tamura G. Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer [Ｊ]. World J Gastroenterol, 2006; 12(2): 192-198.
20.	Jeong YW, Kim KS, Oh JY, et al. Exogenous wild-type p16INK4A gene induces delayed cell proliferation and promotes chemosensitivity through decreased pRB and increased E2F-1 expressions [Ｊ]. Int J Mol Med, 2003; 12(1): 61-65.
21.	Guo C, Ding J, Yao L, et al. Tumor suppressor gene Runx3 sensitizes gastric cancer cells to chemotherapeutic drugs by downregulating Bcl-2, MDR-1 and MRP-1 [Ｊ]. Int J Cancer, 2005; 116(1): 155-160.
22.	Wels W, Moritz D, Schmidt M, et al. Biotechnological and gene therapeutic strategies in cancer treatment [Ｊ]. Gene, 1995; 159(1): 73-80.
23.	Ogiso Y, Sakai N, Watari H, et al. Suppression of various human tumor cell lines by a dominant negative H-ras mutant [Ｊ]. Gene Ther, 1994; 1(6): 403-407.
24.	Essner R, Huynh Y, Nguyen T, et al. Functional interleukin-4 receptor and interleukin-2 receptor common gamma chain in human gastric carcinoma: a possible mechanism for cytokine-based therapy [Ｊ]. J Gastrointest Surg, 2001; 5(1): 81-90.
25.	Zhao ZG, Shen WL. Heat shock protein 70 antisense oligonucleotide inhibits cell growth and induces apoptosis in human gastric cancer cell line SGC-7901 [Ｊ]. World J Gastroenterol, 2005; 11(1): 73-78.
26.	Kosaka K, Yashiro M, Sakate Y, et al. CD80 gene therapy for lymph node involvement by gastric carcinoma [Ｊ]. Int J Oncol, 2004; 25(5): 1319-1325.
27.	Yoshida T, Mizuno M, Taniguchi K, et al. Rat glioma cell death induced by cationic liposome-mediated transfer of the herpes simplex virus thymidine kinase gene followed by ganciclovir treatment [Ｊ]. J Surg Oncol, 2001; 76(1): 19-25.
28.	Matsukura N, Onda M, Shimada T. Possibility and future problems of gene therapy for gastric cancer [Ｊ]. Nippon Geka Gakkai Zasshi, 2001; 102(10): 778-782.
29.	Ueda K, Iwahashi M, Nakamori M, et al. Carcinoembryonic antigen-specific suicide gene therapy of cytosine deaminase/5-fluorocytosine enhanced by the cre/loxP system in the orthotopic gastric carcinoma model [Ｊ]. Cancer Res, 2001; 61(16): 6158-6162.

1. 杨少辉, 戴冬秋. 肿瘤抑制基因甲基化与胃癌 [Ｊ]. 中国普外基础与临床杂志, 2006; 13(5): 614-616.
2. 黄斌, 李昂, 张波, 等. 纳米炭吸附5-FU淋巴靶向化疗对胃癌组织及转移淋巴结bcl-2、bax及caspase-3表达的影响 [Ｊ]. 中国普外基础与临床杂志, 2009; 16(1): 18-22.
3. Deng D, El-Rifai W, Ji J, et al. Hypermethylation of metallothionein-3 CpG island in gastric carcinoma [Ｊ]. Carcinogenesis, 2003; 24(1): 25-29.
4. Tanaka H, Yashiro M, Sunami T, et al. ICAM-2 gene therapy for peritoneal dissemination of scirrhous gastric carcinoma [Ｊ]. Clin Cancer Res, 2004; 10(14): 4885-4892.
5. Carneiro F, Oliveira C, Leite M, et al. Molecular targets and biological modifiers in gastric cancer [Ｊ]. Semin Diagn Pathol, 2008; 25(4): 274-287.
6. Ficorella C, Cannita K, Ricevuto E, et al. P16 hypermethylation contributes to the characterization of gene inactivation profiles in primary gastric cancer [Ｊ]. Oncol Rep, 2003; 10(1): 169-173.
7. Jones PA, Takai D. The role of DNA methylation in mammalian epigenetics [Ｊ]. Science, 2001; 293(5532): 1068-1070.
8. Leung WK, Yu J, Ng EK, et al. Concurrent hypermethylation of multiple tumor-related genes in gastric carcinoma and adjacent normal tissues [Ｊ]. Cancer, 2001; 91(12): 2294-2301.
9. 温爽, 刘天卿, 李梅, 等. 胃黏膜上皮错配修复基因hMLH1表达在胃癌诊断中的临床意义 [Ｊ]. 大连医科大学学报, 2007; 29 (6): 539-541.
10. Schimmer AD. Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice [Ｊ]. Cancer Res, 2004; 64(20): 7183-7190.
11. Altieri DC. The molecular basis and potential role of survivin in cancer diagnosis and therapy [Ｊ]. Trends Mol Med, 2001; 7(12): 542-547.
12. 何满西, 李耿, 姚有贵, 等. 胰腺癌细胞survivin表达RNAi抑制载体的构建及其抑制作用的研究 [Ｊ]. 中国普外基础与临床杂志, 2008; 15(11)： 829-834.
13. 张成斌, 燕善军, 王启之, 等. survivin基因检测在胃癌辅助诊断中的应用 [Ｊ]. 蚌埠医学院学报, 2007; 32(6): 649-652.
14. 刘平, 王同杉, 游思洪, 等. livin在人胃癌组织中的表达及其沉默后对胃癌细胞凋亡的影响 [Ｊ]. 中华肿瘤杂志, 2007; 29(8): 570-574.
15. 李中福, 王子卫. 胃癌组织中Livin的表达及意义 [Ｊ]. 中华消化外科杂志, 2008; 7(3): 177-179.
16. Nishimura T. Total number of genome alterations in sporadic gastrointestinal cancer inferred from pooled analyses in the literature [Ｊ]. Tumour Biol, 2008; 29(6): 343-350.
17. Wen SF, Xie L, McDonald M, et al. Development and validation of sensitive assays to quantitate gene expression after p53 gene therapy and paclitaxel chemotherapy using in vivo dosing in tumor xenograft models [Ｊ]. Cancer Gene Ther, 2000; 7(11): 1469-1480.
18. Ohashi M, Kanai F, Ueno H, et al. Adenovirus mediated p53 tumour suppressor gene therapy for human gastric cancer cells in vitro and in vivo [Ｊ]. Gut, 1999; 44(3): 366-371.
19. Tamura G. Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer [Ｊ]. World J Gastroenterol, 2006; 12(2): 192-198.
20. Jeong YW, Kim KS, Oh JY, et al. Exogenous wild-type p16INK4A gene induces delayed cell proliferation and promotes chemosensitivity through decreased pRB and increased E2F-1 expressions [Ｊ]. Int J Mol Med, 2003; 12(1): 61-65.
21. Guo C, Ding J, Yao L, et al. Tumor suppressor gene Runx3 sensitizes gastric cancer cells to chemotherapeutic drugs by downregulating Bcl-2, MDR-1 and MRP-1 [Ｊ]. Int J Cancer, 2005; 116(1): 155-160.
22. Wels W, Moritz D, Schmidt M, et al. Biotechnological and gene therapeutic strategies in cancer treatment [Ｊ]. Gene, 1995; 159(1): 73-80.
23. Ogiso Y, Sakai N, Watari H, et al. Suppression of various human tumor cell lines by a dominant negative H-ras mutant [Ｊ]. Gene Ther, 1994; 1(6): 403-407.
24. Essner R, Huynh Y, Nguyen T, et al. Functional interleukin-4 receptor and interleukin-2 receptor common gamma chain in human gastric carcinoma: a possible mechanism for cytokine-based therapy [Ｊ]. J Gastrointest Surg, 2001; 5(1): 81-90.
25. Zhao ZG, Shen WL. Heat shock protein 70 antisense oligonucleotide inhibits cell growth and induces apoptosis in human gastric cancer cell line SGC-7901 [Ｊ]. World J Gastroenterol, 2005; 11(1): 73-78.
26. Kosaka K, Yashiro M, Sakate Y, et al. CD80 gene therapy for lymph node involvement by gastric carcinoma [Ｊ]. Int J Oncol, 2004; 25(5): 1319-1325.
27. Yoshida T, Mizuno M, Taniguchi K, et al. Rat glioma cell death induced by cationic liposome-mediated transfer of the herpes simplex virus thymidine kinase gene followed by ganciclovir treatment [Ｊ]. J Surg Oncol, 2001; 76(1): 19-25.
28. Matsukura N, Onda M, Shimada T. Possibility and future problems of gene therapy for gastric cancer [Ｊ]. Nippon Geka Gakkai Zasshi, 2001; 102(10): 778-782.
29. Ueda K, Iwahashi M, Nakamori M, et al. Carcinoembryonic antigen-specific suicide gene therapy of cytosine deaminase/5-fluorocytosine enhanced by the cre/loxP system in the orthotopic gastric carcinoma model [Ｊ]. Cancer Res, 2001; 61(16): 6158-6162.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Advancement of Gene Diagnosis and Gene Therapy on Gastric Cancer

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