Liver Retransplantation: Report of 6 Cases and Review of Literature_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Qiyu , CHEN Gang , WEN Xiaoming , ZHAO Yingpeng , ZHU Xinfeng , LI Xiaoyan , LI Li

Department of Hepatobiliary Surgery, The First People’s Hospital of Kunming City;;
Liver Transplantation Center of Yunnan Province, Kunming 650011, China;

Corresponding author：

Keywords：

Liver transplantation; Poor graft function; Rejection; Complication; Liver retransplantation

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Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the clinical experience of liver retransplantation.
Methods Six liver retransplantations were performed. The indications consisted of primary non-function (PNF, 2 cases), acute or chronic rejection (2 cases), stomas stenosis of biliary tract (1 case) and primary sclerosing cholangitis (1 case). The immunosuppressive protocols included tacrolimus, methylprednisolone (MP) and mycophenolate mofetil (MMF).
Results Five patients were cured. One patient died on day 4 after liver retransplantation because of multiple organ failure. Postoperative complications included deep fungal infection and wound infection.
Conclusions Liver retransplantation is an effective method for graft failure after liver transplantation. Proper indication and optimum operative time, intensive perioperative supervision and proper treatment are very important to improv effect of liver retransplantation.

Citation： LIU Qiyu,CHEN Gang,WEN Xiaoming,ZHAO Yingpeng,ZHU Xinfeng,LI Xiaoyan,LI Li. Liver Retransplantation: Report of 6 Cases and Review of Literature. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2009, 16(7): 540-544. doi: Copy

1.	严律南. 成人间活体肝移植的外科技术与创新 [Ｊ]. 中国普外基础与临床杂志， 2008； 15（3）： 151154.
2.	吕波，文天夫. 肝癌肝移植及肝癌肝切除术后复发特点的比较 [Ｊ]. 中国普外基础与临床杂志， 2008； 15（3）： 166170.
3.	Ghabril M, Dickson RC, Machicao VI, et al. Liver retransplantation of patients with hepatitis C infection is associated with acceptable patient and graft survival [Ｊ]. Liver Transpl, 2007； 13(12): 17171727.
4.	Ghabril M, Dickson R, Wiesner R. Improving outcomes of liver retransplantation: an analysis of trends and the impact of Hepatitis C infection [Ｊ]. Am J Transplant， 2008； 8(2): 404411.
5.	Ghobrial RM. Changing faces of liver retransplantation: it is all about selection [Ｊ]. Liver Transplantation, 2007； 13(2): 188189.
6.	Yamauchi Y, Wettergren A, Yamashita Y, et al. Retransplantation of the liver in adults: longterm outcome and prognostic modeling [Ｊ]. Hepatogastroenterology， 2007； 54(76): 11811186.
7.	Ng V, Anand R, Martz K, et al. Liver retransplantation in children: a SPLIT database analysis of outcome and predictive factors for survival [Ｊ]. Am J Transplant， 2008； 8(2): 386395.
8.	Martí J, Charco R, Ferrer J, et al. Optimization of liver grafts in liver retransplantation: a European singlecenter experience [Ｊ]. Surgery， 2008； 144(5): 762769.
9.	Selck FW, Grossman EB, Ratner LE, et al. Utilization, outcomes, and retransplantation of liver allografts from donation after cardiac death: implications for further expansion of the deceaseddonor pool [Ｊ]. Ann Surg， 2008； 248(4): 599607.
10.	Reese PP, Yeh H, Thomasson AM, et al. Transplant center volume and outcomes after liver retransplantation [Ｊ]. Am J Transplant， 2009； 9(2): 309317.
11.	Davis A, Rosenthal P, Glidden D. Pediatric liver retransplantation: outcomes and a prognostic scoring tool [Ｊ]. Liver Transpl， 2009； 15(2): 199207.
12.	Magee JC, Barr ML, Basadonna GP, et al. Repeat organ transplantation in the United States, 19962005 [Ｊ]. Am J Transplant， 2007; 7(5 Pt 2): 14241433.
13.	Sun CK, Chen CL, Concejero AM, et al. Retransplantation for endstage liver disease: a singlecenter Asian experience [Ｊ]. Transplant Proc， 2008； 40(8): 25032506.
14.	Zhu ZJ, Rao W, Sun JS, et al. Liver retransplantation for ischemictype biliary lesions after orthotopic liver transplantation: a clinical report of 66 cases [Ｊ]. Hepatobiliary Pancreat Dis Int，2008； 7(5): 471475.
15.	Kwo PY, Saxena R, Cummings OW, et al. Intravenous interferon during the anhepatic phase of liver retransplantation and prevention of recurrence of cholestatic hepatitis C virus [Ｊ]. Liver Transpl， 2007； 13(12): 17101713.
16.	Rosen HR. Liver retransplantation for hepatitis C: seeing is believing [Ｊ]. Liver Transpl, 2007； 13(9): 12171218.
17.	Uemura T, Randall HB, Sanchez EQ, et al. Liver retransplantation for primary nonfunction: analysis of a 20year singlecenter experience [Ｊ]. Liver Transpl， 2007；13(2): 227233.
18.	Bonatti H, Goegele H, Tabarelli D, et al. Pseudallescheria boydii infection after liver retransplantation [Ｊ]. Liver Transpl， 2007； 13(7): 10681069.
19.	DobleckiLewis S, Palaios E, Bejarano PA, et al. Hepatic gas gangrene following orthotopic liver transplantation: three cases treated with retransplantation and a review of the literature [Ｊ]. Transpl Infect Dis， 2008； 10(4): 280285.
20.	Garcia JH, Vasconcelos JB, Gonalves BP, et al. A new biliodigestive anastomosis technique after hepatic artery thrombosis as bridge to liver retransplantation: a case presentation [Ｊ]. Transplant Proc， 2007； 39(10): 35233526.
21.	冉江华，张升宁，李铸，等 . 肝动脉腹主动脉搭桥在原位肝移植术中的应用 [Ｊ]. 中国普外基础与临床杂志， 2008； 15（2）： 102105.
22.	Maggi U, Consonni D, Bertoli P, et al. A risk score and a flowchart for liver retransplantation [Ｊ]. Transplant Proc， 2008； 40(6): 19561960.
23.	Lang H, Sotiropoulos GC, Beckebaum S, et al. Incidence of liver retransplantation and its effect on patient survival [Ｊ]. Transplant Proc， 2008； 40(9): 32013203.
24.	Yan JQ, Peng CH, Li HW, et al. Preliminary clinical experience in liver retransplantation [Ｊ]. Hepatobiliary Pancreat Dis Int， 2007； 6(2): 152156.
25.	Uribe M, Buckel E, Ferrario M, et al. Pediatric liver retransplantation: indications and outcome [Ｊ]. Transplant Proc， 2007； 39(3): 609611.
26.	Qasim A, Zaman BM, Geoghegan J, et al. Significant influence of the primary liver disease on the outcomes of hepatic retransplantation [Ｊ]. Ir J Med Sci， 2009； 178(1): 4751.

1. 严律南. 成人间活体肝移植的外科技术与创新 [Ｊ]. 中国普外基础与临床杂志， 2008； 15（3）： 151154.
2. 吕波，文天夫. 肝癌肝移植及肝癌肝切除术后复发特点的比较 [Ｊ]. 中国普外基础与临床杂志， 2008； 15（3）： 166170.
3. Ghabril M, Dickson RC, Machicao VI, et al. Liver retransplantation of patients with hepatitis C infection is associated with acceptable patient and graft survival [Ｊ]. Liver Transpl, 2007； 13(12): 17171727.
4. Ghabril M, Dickson R, Wiesner R. Improving outcomes of liver retransplantation: an analysis of trends and the impact of Hepatitis C infection [Ｊ]. Am J Transplant， 2008； 8(2): 404411.
5. Ghobrial RM. Changing faces of liver retransplantation: it is all about selection [Ｊ]. Liver Transplantation, 2007； 13(2): 188189.
6. Yamauchi Y, Wettergren A, Yamashita Y, et al. Retransplantation of the liver in adults: longterm outcome and prognostic modeling [Ｊ]. Hepatogastroenterology， 2007； 54(76): 11811186.
7. Ng V, Anand R, Martz K, et al. Liver retransplantation in children: a SPLIT database analysis of outcome and predictive factors for survival [Ｊ]. Am J Transplant， 2008； 8(2): 386395.
8. Martí J, Charco R, Ferrer J, et al. Optimization of liver grafts in liver retransplantation: a European singlecenter experience [Ｊ]. Surgery， 2008； 144(5): 762769.
9. Selck FW, Grossman EB, Ratner LE, et al. Utilization, outcomes, and retransplantation of liver allografts from donation after cardiac death: implications for further expansion of the deceaseddonor pool [Ｊ]. Ann Surg， 2008； 248(4): 599607.
10. Reese PP, Yeh H, Thomasson AM, et al. Transplant center volume and outcomes after liver retransplantation [Ｊ]. Am J Transplant， 2009； 9(2): 309317.
11. Davis A, Rosenthal P, Glidden D. Pediatric liver retransplantation: outcomes and a prognostic scoring tool [Ｊ]. Liver Transpl， 2009； 15(2): 199207.
12. Magee JC, Barr ML, Basadonna GP, et al. Repeat organ transplantation in the United States, 19962005 [Ｊ]. Am J Transplant， 2007; 7(5 Pt 2): 14241433.
13. Sun CK, Chen CL, Concejero AM, et al. Retransplantation for endstage liver disease: a singlecenter Asian experience [Ｊ]. Transplant Proc， 2008； 40(8): 25032506.
14. Zhu ZJ, Rao W, Sun JS, et al. Liver retransplantation for ischemictype biliary lesions after orthotopic liver transplantation: a clinical report of 66 cases [Ｊ]. Hepatobiliary Pancreat Dis Int，2008； 7(5): 471475.
15. Kwo PY, Saxena R, Cummings OW, et al. Intravenous interferon during the anhepatic phase of liver retransplantation and prevention of recurrence of cholestatic hepatitis C virus [Ｊ]. Liver Transpl， 2007； 13(12): 17101713.
16. Rosen HR. Liver retransplantation for hepatitis C: seeing is believing [Ｊ]. Liver Transpl, 2007； 13(9): 12171218.
17. Uemura T, Randall HB, Sanchez EQ, et al. Liver retransplantation for primary nonfunction: analysis of a 20year singlecenter experience [Ｊ]. Liver Transpl， 2007；13(2): 227233.
18. Bonatti H, Goegele H, Tabarelli D, et al. Pseudallescheria boydii infection after liver retransplantation [Ｊ]. Liver Transpl， 2007； 13(7): 10681069.
19. DobleckiLewis S, Palaios E, Bejarano PA, et al. Hepatic gas gangrene following orthotopic liver transplantation: three cases treated with retransplantation and a review of the literature [Ｊ]. Transpl Infect Dis， 2008； 10(4): 280285.
20. Garcia JH, Vasconcelos JB, Gonalves BP, et al. A new biliodigestive anastomosis technique after hepatic artery thrombosis as bridge to liver retransplantation: a case presentation [Ｊ]. Transplant Proc， 2007； 39(10): 35233526.
21. 冉江华，张升宁，李铸，等 . 肝动脉腹主动脉搭桥在原位肝移植术中的应用 [Ｊ]. 中国普外基础与临床杂志， 2008； 15（2）： 102105.
22. Maggi U, Consonni D, Bertoli P, et al. A risk score and a flowchart for liver retransplantation [Ｊ]. Transplant Proc， 2008； 40(6): 19561960.
23. Lang H, Sotiropoulos GC, Beckebaum S, et al. Incidence of liver retransplantation and its effect on patient survival [Ｊ]. Transplant Proc， 2008； 40(9): 32013203.
24. Yan JQ, Peng CH, Li HW, et al. Preliminary clinical experience in liver retransplantation [Ｊ]. Hepatobiliary Pancreat Dis Int， 2007； 6(2): 152156.
25. Uribe M, Buckel E, Ferrario M, et al. Pediatric liver retransplantation: indications and outcome [Ｊ]. Transplant Proc， 2007； 39(3): 609611.
26. Qasim A, Zaman BM, Geoghegan J, et al. Significant influence of the primary liver disease on the outcomes of hepatic retransplantation [Ｊ]. Ir J Med Sci， 2009； 178(1): 4751.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Liver Retransplantation: Report of 6 Cases and Review of Literature

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