Influence of “Liqitongxia Decoction” on Intestinal Barrier Dysfunction of Acute Pancreatitis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

DIAO Yongpeng ¹ , LI Fei ¹ , CHEN Hong ¹ , YANG Lei ¹ , JIA Jianguo ¹ , WANG Yulan ²

1.Department of General Surgery， Xuanwu Hospital, Capital Medical University, Beijing 100053, China;;
2.Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;

Corresponding author：

Keywords：

Liqitongxia decoction; Acute pancreatitis; Intestinal barrier dysfunction; Traditional Chinese drug

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Objective To observe the influence of “liqitongxia decoction” on intestinal barrier dysfunction of acute pancreatitis (AP).
Methods Forty AP patients were randomly divided into “liqitongxia decoction” group (n=20) and magnesium sulfate group (n=20). APACHE Ⅱ score and gastrointestinal functions score (GFS) on admission， at 24 h, 48 h, 72 h and on day 5 after admission were recorded. The ratio of urine lactulose to mannitol (L/M), plasma activity of diamine oxidase (DAO) and the levels of endotoxin, TNF-α and IL-6 on admission, at 72 h and on the day　5 after admission were detected.
Results The ratio of severe AP was not significantly different between two groups (P＞0.05). On the day　5 after admission, APACHEⅡscore and GFS in two groups decreased. The ratio of L/M, the activity of DAO, the levels of endotoxin, TNF-α and IL-6 decreased in “liqitongxia decoction” group and elevated in magnesium sulfate group. The APACHE Ⅱ score was not significantly different between two groups on the day　5 of admission (P＞0.05), but the GFS, the ratio of L/M, the activity of DAO, levels of endotoxin, TNF-α and IL-6 were significantly different between two groups (P＜0.05, P＜0.01).
Conclusion The “liqitongxia decoction” may ameliorate the intestinal barrier dysfunction of patients with acute pancreatitis.

Citation： DIAO Yongpeng ,LI Fei,CHEN Hong,YANG Lei,JIA Jianguo,WANG Yulan. Influence of “Liqitongxia Decoction” on Intestinal Barrier Dysfunction of Acute Pancreatitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2009, 16(8): 637-640. doi: Copy

1.	乔世峰, 孙家邦, 李非. 重症急性胰腺炎患者胰腺感染的相关因素分析及防治措施 [Ｊ]. 中国综合临床， 2006; 22(3): 252-253.
2.	Toouli J， Brooke-Smith M， Bassi C， et al. Guidelines for the management of acute pancreatitis [Ｊ]. J Gastroenterol Hepatol， 2002; 17 Suppl: S15-S39.
3.	王今达，王宝恩. 多脏器功能失常综合征(MODS)病情分期诊断及严重程度评分标准 [Ｊ]. 中国危重病急救医学， 1995; 7(6): 346-347.
4.	夏庆，蒋俊明. 通里攻下法治疗急性胰腺炎的机理研究 [Ｊ]. 中国普外基础与临床杂志， 2001; 8(2): 131-132.
5.	邓高月，刘振邦，徐燕英，等. 高压液色谱用于肠通透性的测定 [Ｊ]. 中国微生态学杂志， 2000; 12(4): 242-244.
6.	黎君友，于燕，郝军，等. 分光光度法测定血和小肠组织二胺氧化酶活性 [Ｊ]. 氨基酸与生物资源， 1996; 18(4): 28-30.
7.	蒲华云. 大黄、硫酸镁辅助治疗重症急性胰腺炎的临床疗效观察 [Ｊ]. 中国普通外科杂志， 2007; 16(10): 1021-1022.
8.	段美丽，张淑文，王宝恩. 中药复方促动胶囊治疗急性胰腺炎患者胃肠运动功能障碍的临床观察 [Ｊ]. 中国中西医结合急救杂志， 2004; 11(1): 36-38.
9.	Tsai JC， Tsai S， Chang WC. Effect of ethanol extracts of three Chinese medicinal plants with laxative properties on ion transport of the rat intestinal epithelia [Ｊ]. Biol Pharm Bull， 2004; 27(2): 162-165.
10.	裴红红，封英群，杨正安，等. 大黄对重症胰腺炎胃肠激素的影响 [Ｊ]. 中国急救医学， 2004; 24(7): 523.
11.	张启荣，丁立，赵训明，等. 厚朴对兔离体胃肠平滑肌运动的影响 [Ｊ]. 陕西医学杂志， 2007; 36(6): 656-659.
12.	孙友俊，刘志苏，汪晖，等. 胰必清颗粒对实验动物胃肠运动的影响 [Ｊ]. 武汉大学学报(医学版)， 2005; 26(3): 379-382.
13.	Ammori BJ， Leeder PC， King RF， et al. Early increase in intestinal permeability in patients with severe acute pancreatitis: correlation with endotoxemia， organ failure， and mortality [Ｊ]. J Gastrointest Surg， 1999; 3(3): 252-262.
14.	Zayat M， Lichtenberger LM， Dial EJ. Pathophysiology of LPS-induced gastrointestinal injury in the rat: role of secretory phospholipase A2 [Ｊ]. Shock， 2008; 30(2): 206-211.
15.	Li Q， Zhang Q， Wang M， et al. Interferon-γ and tumor necrosis factor-α disrupt epithelial barrier function by altering lipid composition in membrane microdomains of tight junction [Ｊ]. Clin immunol， 2008; 126(1): 67-80.
16.	Blikslager AT， Moeser AJ， Gookin JL， et al. Restoration of barrier function in injured intestinal mucosa [Ｊ]. Physiol Rev， 2007; 87(2): 545-564.
17.	Jiang CF， Shiau YC， Ng KW， et al. Serum interleukin-6 tumor necrosis factor α and C-reactive protein in early prediction of severity of acute pancreatitis [Ｊ]. J Chin Med Assoc， 2004; 67(9): 442-446.
18.	Tseng SH， Lee HH， Chen LG， et al. Effects of three purgative decoctions on inflammatory mediators [Ｊ]. J Ethnopharmacol， 2006; 105(1-2): 118-124.
19.	吴承堂，黎沾良. 中药清胰汤对犬急性坏死性胰腺炎肠黏膜损伤修复的影响 [Ｊ]. 中国普外基础与临床杂志， 1998; 5(6): 326-328.

1. 乔世峰, 孙家邦, 李非. 重症急性胰腺炎患者胰腺感染的相关因素分析及防治措施 [Ｊ]. 中国综合临床， 2006; 22(3): 252-253.
2. Toouli J， Brooke-Smith M， Bassi C， et al. Guidelines for the management of acute pancreatitis [Ｊ]. J Gastroenterol Hepatol， 2002; 17 Suppl: S15-S39.
3. 王今达，王宝恩. 多脏器功能失常综合征(MODS)病情分期诊断及严重程度评分标准 [Ｊ]. 中国危重病急救医学， 1995; 7(6): 346-347.
4. 夏庆，蒋俊明. 通里攻下法治疗急性胰腺炎的机理研究 [Ｊ]. 中国普外基础与临床杂志， 2001; 8(2): 131-132.
5. 邓高月，刘振邦，徐燕英，等. 高压液色谱用于肠通透性的测定 [Ｊ]. 中国微生态学杂志， 2000; 12(4): 242-244.
6. 黎君友，于燕，郝军，等. 分光光度法测定血和小肠组织二胺氧化酶活性 [Ｊ]. 氨基酸与生物资源， 1996; 18(4): 28-30.
7. 蒲华云. 大黄、硫酸镁辅助治疗重症急性胰腺炎的临床疗效观察 [Ｊ]. 中国普通外科杂志， 2007; 16(10): 1021-1022.
8. 段美丽，张淑文，王宝恩. 中药复方促动胶囊治疗急性胰腺炎患者胃肠运动功能障碍的临床观察 [Ｊ]. 中国中西医结合急救杂志， 2004; 11(1): 36-38.
9. Tsai JC， Tsai S， Chang WC. Effect of ethanol extracts of three Chinese medicinal plants with laxative properties on ion transport of the rat intestinal epithelia [Ｊ]. Biol Pharm Bull， 2004; 27(2): 162-165.
10. 裴红红，封英群，杨正安，等. 大黄对重症胰腺炎胃肠激素的影响 [Ｊ]. 中国急救医学， 2004; 24(7): 523.
11. 张启荣，丁立，赵训明，等. 厚朴对兔离体胃肠平滑肌运动的影响 [Ｊ]. 陕西医学杂志， 2007; 36(6): 656-659.
12. 孙友俊，刘志苏，汪晖，等. 胰必清颗粒对实验动物胃肠运动的影响 [Ｊ]. 武汉大学学报(医学版)， 2005; 26(3): 379-382.
13. Ammori BJ， Leeder PC， King RF， et al. Early increase in intestinal permeability in patients with severe acute pancreatitis: correlation with endotoxemia， organ failure， and mortality [Ｊ]. J Gastrointest Surg， 1999; 3(3): 252-262.
14. Zayat M， Lichtenberger LM， Dial EJ. Pathophysiology of LPS-induced gastrointestinal injury in the rat: role of secretory phospholipase A2 [Ｊ]. Shock， 2008; 30(2): 206-211.
15. Li Q， Zhang Q， Wang M， et al. Interferon-γ and tumor necrosis factor-α disrupt epithelial barrier function by altering lipid composition in membrane microdomains of tight junction [Ｊ]. Clin immunol， 2008; 126(1): 67-80.
16. Blikslager AT， Moeser AJ， Gookin JL， et al. Restoration of barrier function in injured intestinal mucosa [Ｊ]. Physiol Rev， 2007; 87(2): 545-564.
17. Jiang CF， Shiau YC， Ng KW， et al. Serum interleukin-6 tumor necrosis factor α and C-reactive protein in early prediction of severity of acute pancreatitis [Ｊ]. J Chin Med Assoc， 2004; 67(9): 442-446.
18. Tseng SH， Lee HH， Chen LG， et al. Effects of three purgative decoctions on inflammatory mediators [Ｊ]. J Ethnopharmacol， 2006; 105(1-2): 118-124.
19. 吴承堂，黎沾良. 中药清胰汤对犬急性坏死性胰腺炎肠黏膜损伤修复的影响 [Ｊ]. 中国普外基础与临床杂志， 1998; 5(6): 326-328.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Influence of “Liqitongxia Decoction” on Intestinal Barrier Dysfunction of Acute Pancreatitis

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