Expression and Clinical Significance of Connective Tissue Growth Factor in Colorectal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

SI Picheng , XU Jianguo , HUANG Huimin , LI Litao.

Department of General Surgery， Heyuan People’s Hospital， Heyuan 517000， Guangdong Province， ChinaCorresponding Author: SI Pi-cheng, E-mail: spc1968@163.com;

Corresponding author：

Keywords：

Connective tissue growth factor; Colorectal cancer; Gene expression; Immunohistochemical method

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Objective 　To investigate the expression and clinical significance of connective tissue growth factor (CTGF) in colorectal cancer.
Methods 　The expressions of CTGF in 62 patients’ colorectal cancer tissues and their corresponding adjacent tissues were detected by SP immunohistochemical method. The results were statistically analyzed.
Results 　The positive rates of CTGF in colorectal cancer and adjacent tissues were 61.3% and 19.4% respectively， and the difference between them was significant (P＜0.05). The expression of CTGF was related to degree of differentiation, depth of infiltration and lymph node metastasis or not (P＜0.05）, namely the lower degree of differentiation, the deeper depth of infiltration and the more lymph node metastasis, the corresponding positive expression rates were lower (P=0.030, P=0.032 and P=0.017 respectively), but correlation with gender was not significant (P gt;0.05）.
Conclusion 　CTGF may play an important role in the occurrence of colorectal cancer， which contributes a lot to guide clinical treatment and prognosis.

Citation： SI Picheng,XU Jianguo,HUANG Huimin,LI Litao.. Expression and Clinical Significance of Connective Tissue Growth Factor in Colorectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2009, 16(9): 706-709. doi: Copy

1.	[1０]Derynck R, Feng XH. TGF-beta receptor signaling [Ｊ]. Biochim Biophys Acta, 1997; 1333(2): F105-F150.
2.	[1３]Xie D, Yin D, Wang HJ, et al. Levels of expression of CYR61 and CTGF are prognostic for tumor progression and survival of individuals with gliomas [Ｊ]. Clin Cancer Res, 2004; 10(6): 2072-2081.
3.	[1４]Lin BR, Chang CC, Che TF, et al. Connective tissue growth factor inhibits metastasis and acts as an independent prognostic marker in colorectal cancer [Ｊ]. Gastroenterology, 2005; 128(1): 9-23.
4.	[1５]Zeng ZJ, Yang LY, Ding X, et al. Expressions of cysteine-rich61, connective tissue growth factor and Nov genes in hepatocellular carcinoma and their clinical significance [Ｊ]. World J Gastroenterol, 2004; 10(23): 3414-3418.
5.	[1６]Hartel M, Di Mola FF, Gardini A, et al. Desmoplastic reaction influences pancreatic cancer growth behavior [Ｊ]. World J Surg, 2004; 28(8): 818-825.
6.	[1７]Chang CC, Lin MT, Lin BR, et al. Effect of connective tissue growth factor on hypoxia-inducible factor 1α degradation and tumor angiogenesis [Ｊ]. J Natl Cancer Inst, 2006; 98(14): 984-995.
7.	Peto J. Cancer epidemiology in the last century and the next decade [Ｊ]. Nature, 2001; 411(6835): 390-395.
8.	Tsukuma H, Ajiki W. Descriptive epidemiology of colorectal cancer—international comparison [Ｊ]. Nippon Rinsho, 2003; 61 Suppl 7: 25-30.[３]吴孟超, 吴在德主编. 黄家驷外科学 [M]. 第7版. 北京: 人民卫生出版社， 2008: 1558.[４]Moritani NH, Kubota S, Nishida T, et al. Suppressive effect of overexpressed connective tissue growth factor on tumor cell growth in a human oral squamous cell carcinoma-derived cell line [Ｊ]. Cancer Lett, 2003; 192(2): 205-214. [５]李友忠, 卢永德, 曾益慈, 等. 喉鳞状细胞癌组织中CTGF和OPN的表达及其临床意义 [Ｊ]. 临床耳鼻咽喉头颈外科杂志, 2007; 21(3): 121-123.[６]孙小娟. 大肠癌的靶向治疗 [Ｊ]. 岭南现代临床外科, 2007; 7（5）: 393-396.[７]Bradham DM, Igarashi A, Potter RL, et al. Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10 [Ｊ]. J Cell Biol, 1991; 114(6): 1285-1294.[８]Rachfal AW, Brigstock DR. Structural and functional properties of CCN proteins [Ｊ]. Vitam Horm, 2005; 70: 69-103. [９]王春雷, 黄志强, 万远廉. TGF-β1诱导人肝癌细胞系凋亡信号转导机理的研究 [Ｊ]. 中国普外基础与临床杂志, 2005; 12(5): 480-487.
9.	肖在鹏, 胡祥, 杨佩满, 等. 结缔组织生长因子在胃硬癌形成机制中的作用 [Ｊ]. 中国医师进修杂志, 2007; 30(6): 8-11.
10.	Koliopanos A, Friess H, di Mola FF, et al. Connective tissue growth factor gene expression alters tumor progression in esophageal cancer [Ｊ]. World J Surg, 2002; 26(4): 420-427.

1. [1０]Derynck R, Feng XH. TGF-beta receptor signaling [Ｊ]. Biochim Biophys Acta, 1997; 1333(2): F105-F150.
2. [1３]Xie D, Yin D, Wang HJ, et al. Levels of expression of CYR61 and CTGF are prognostic for tumor progression and survival of individuals with gliomas [Ｊ]. Clin Cancer Res, 2004; 10(6): 2072-2081.
3. [1４]Lin BR, Chang CC, Che TF, et al. Connective tissue growth factor inhibits metastasis and acts as an independent prognostic marker in colorectal cancer [Ｊ]. Gastroenterology, 2005; 128(1): 9-23.
4. [1５]Zeng ZJ, Yang LY, Ding X, et al. Expressions of cysteine-rich61, connective tissue growth factor and Nov genes in hepatocellular carcinoma and their clinical significance [Ｊ]. World J Gastroenterol, 2004; 10(23): 3414-3418.
5. [1６]Hartel M, Di Mola FF, Gardini A, et al. Desmoplastic reaction influences pancreatic cancer growth behavior [Ｊ]. World J Surg, 2004; 28(8): 818-825.
6. [1７]Chang CC, Lin MT, Lin BR, et al. Effect of connective tissue growth factor on hypoxia-inducible factor 1α degradation and tumor angiogenesis [Ｊ]. J Natl Cancer Inst, 2006; 98(14): 984-995.
7. Peto J. Cancer epidemiology in the last century and the next decade [Ｊ]. Nature, 2001; 411(6835): 390-395.
8. Tsukuma H, Ajiki W. Descriptive epidemiology of colorectal cancer—international comparison [Ｊ]. Nippon Rinsho, 2003; 61 Suppl 7: 25-30.[３]吴孟超, 吴在德主编. 黄家驷外科学 [M]. 第7版. 北京: 人民卫生出版社， 2008: 1558.[４]Moritani NH, Kubota S, Nishida T, et al. Suppressive effect of overexpressed connective tissue growth factor on tumor cell growth in a human oral squamous cell carcinoma-derived cell line [Ｊ]. Cancer Lett, 2003; 192(2): 205-214. [５]李友忠, 卢永德, 曾益慈, 等. 喉鳞状细胞癌组织中CTGF和OPN的表达及其临床意义 [Ｊ]. 临床耳鼻咽喉头颈外科杂志, 2007; 21(3): 121-123.[６]孙小娟. 大肠癌的靶向治疗 [Ｊ]. 岭南现代临床外科, 2007; 7（5）: 393-396.[７]Bradham DM, Igarashi A, Potter RL, et al. Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10 [Ｊ]. J Cell Biol, 1991; 114(6): 1285-1294.[８]Rachfal AW, Brigstock DR. Structural and functional properties of CCN proteins [Ｊ]. Vitam Horm, 2005; 70: 69-103. [９]王春雷, 黄志强, 万远廉. TGF-β1诱导人肝癌细胞系凋亡信号转导机理的研究 [Ｊ]. 中国普外基础与临床杂志, 2005; 12(5): 480-487.
9. 肖在鹏, 胡祥, 杨佩满, 等. 结缔组织生长因子在胃硬癌形成机制中的作用 [Ｊ]. 中国医师进修杂志, 2007; 30(6): 8-11.
10. Koliopanos A, Friess H, di Mola FF, et al. Connective tissue growth factor gene expression alters tumor progression in esophageal cancer [Ｊ]. World J Surg, 2002; 26(4): 420-427.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression and Clinical Significance of Connective Tissue Growth Factor in Colorectal Cancer

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