【Abstract】ObjectiveTo evaluate the efficacy of whole body hyperthermia (WBH) in the treatment of advanced hepatic carcinoma and its effect on liver function.
MethodsFrom 2001 to 2004, 39 cases of advanced hepatic carcinoma were treated with WBH. The effect of WBH on liver function was assessed by liver function test before and after treatment.
Results①The effective rate of WBH was 61.5%（24／39） in the treatment of advanced hepatic carcinoma with declined AFP in 60.0%（9/15） of patient and 100% of patients had pain relieve. The survival rates of 6 months, 1 year and 2 years were 76.9%（30/39）, 59.0%（23/39） and 12.8%（5/39）, respectively. ②Alanine aminotransferase (ALT) elevated obviously in 1-3 d after treatment (P lt;0.05), and then approached to its baseline in 7 d. Aspartate aminotransferase (AST) increased significantly 1 d after treatment (P lt;0.05),and then back to its baseline in 3-7 d. Albumin (ALB) appeared dropped 1 d after treatment (P lt;0.05), and restored normally in 3 d. The levels of total bilirubin (TBIL) and gamma glutamyl transpeptidase (GGT) had no evident significant change with the WBH treatment in abnormal liver function group, but TBIL increased 1-3 d after treatment in normal liver function group (P lt;0.05).
ConclusionIn the treatment of advanced hepatic carcinoma, WBH can improve the patients’ life quality and prolong their life expectancy. Meanwhile, it could also result in reversible impairment of liver function.
Citation：
YE Xiaoming,ZHU Yifan,LIANG Lijian.. Whole Body Hyperthermia in Treatment of 39 Cases of Advanced Hepatic Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(2): 175-177. doi:
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| 1. |
[Ｊ]. Front Biosci, 2002； 1(7)∶ 43.
|
| 2. |
[Ｊ]. Clin Exp Metastasis, 2000； 18(2)∶131.
|
| 3. |
Manjili MH, Wang XY, Park J, et al. Immunotherapy of cancer using heat shock proteins.
|
| 4. |
Sawaji Y, Sato T, Takeuchi A, et al. Antiangiogenic action of hyperthermia by suppressing gene expression and production of tumourderived vascular endothelial growth factor in vivo and in vitro [Ｊ]. Br J Cancer, 2002； 86(10)∶1597.
|
| 5. |
Sawaji Y, Sato T, Seiki M, et al. Heat shockmediated transient increase in intracellular 3’,5’cyclic AMP results in tumor specific suppression of membrane type 1matrix metalloproteinase production and progelatinase A activation.
|
| 6. |
Wiedemann GJ, Robins HI, Katschinski DM, et al. Systemic hyperthermia and ICE chemotherapy for sarcoma patients: rationale and clinical status [Ｊ]. Anticancer Res, 1997； 17(4B)∶2899.
|
| 7. |
Hildebrandt B, Wust P, Ahlers O, et al. The cellular and molecular basis of hyperthermia [Ｊ]. Crit Rev Oncol Hematol, 2002； 43(1)∶33.
|
| 8. |
Katschinski DM, Wiedemann GJ, Longo W, et al. Whole body hyperthermia cytokine induction: a review, and unifying hypothesis for myeloprotection in the setting of cytotoxic therapy [Ｊ]. Cytokine Growth Factor Rev, 1999； 10(2)∶93.
|
| 9. |
叶小鸣， 黄文起， 程权永， 等. 体外循环全身热灌注疗法治疗恶性肿瘤81例报告 [Ｊ]. 中国实用外科杂志， 2006； 26(1)∶54.
|
- 1. [Ｊ]. Front Biosci, 2002； 1(7)∶ 43.
- 2. [Ｊ]. Clin Exp Metastasis, 2000； 18(2)∶131.
- 3. Manjili MH, Wang XY, Park J, et al. Immunotherapy of cancer using heat shock proteins.
- 4. Sawaji Y, Sato T, Takeuchi A, et al. Antiangiogenic action of hyperthermia by suppressing gene expression and production of tumourderived vascular endothelial growth factor in vivo and in vitro [Ｊ]. Br J Cancer, 2002； 86(10)∶1597.
- 5. Sawaji Y, Sato T, Seiki M, et al. Heat shockmediated transient increase in intracellular 3’,5’cyclic AMP results in tumor specific suppression of membrane type 1matrix metalloproteinase production and progelatinase A activation.
- 6. Wiedemann GJ, Robins HI, Katschinski DM, et al. Systemic hyperthermia and ICE chemotherapy for sarcoma patients: rationale and clinical status [Ｊ]. Anticancer Res, 1997； 17(4B)∶2899.
- 7. Hildebrandt B, Wust P, Ahlers O, et al. The cellular and molecular basis of hyperthermia [Ｊ]. Crit Rev Oncol Hematol, 2002； 43(1)∶33.
- 8. Katschinski DM, Wiedemann GJ, Longo W, et al. Whole body hyperthermia cytokine induction: a review, and unifying hypothesis for myeloprotection in the setting of cytotoxic therapy [Ｊ]. Cytokine Growth Factor Rev, 1999； 10(2)∶93.
- 9. 叶小鸣， 黄文起， 程权永， 等. 体外循环全身热灌注疗法治疗恶性肿瘤81例报告 [Ｊ]. 中国实用外科杂志， 2006； 26(1)∶54.
