Study about Bacterial Translocation_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

XIAO Fei , KANG Yan.

Intensive Care Unit， West China Hospital， Sichuan University， Chengdu 610041， China;

Corresponding author：

Keywords：

Bacterial translocation Endotoxin translocation Systemic inflammatory response syndrome

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【Abstract】ObjectiveThere are two main functions of gastrointestinal tract, digestion and absorption, and barrier function. The latter has an important defensive effect, which keeps the body away from the invading and damaging of bacteria and endotoxin. It maintains the systemic homeostasis. Intestinal dysfunction would happen when body suffers from diseases or harmful stimulations. The more serious intestinal disorders would harm the intestinal protective mechanism, or intestinal barrier function, and bacterial/endotoxin translocation, of intestinal failure (IF) would ensue. This article provides a critical review of the evidence indicating that an increase in bacterial translocation is associated with sepsis, and even the multiple organ failure syndrome in critically ill patients. The intransit microorganisms play an essential role in the homeostasis of local and systemic immunity.
MethodsAll studies published from 2000 to June 2005 about intestinal permeability, bacterial translocation, and systemic inflammatory response syndrome were located by search of PubMed.
ResultsClinical and experimental studies investigating the correlation between bacterial translocation and systemic inflammatory response syndrome, associated with the damage of the gut barrier function . To keep the mucosal barrier function intact is one of the main issues in the prevention of bacterial translocation. This could be achieved by the adequate delivery of oxygen and nutrient supplementation to the gut. Enteral nutrition, probiotic can be a good choice.
ConclusionWith a better understanding of the bacteriahost interactions in health and the alterations induced by critical illness, new therapies that improve the environment of both may lead to better recovery rates in intensive care unit patients.

Citation： XIAO Fei,KANG Yan.. Study about Bacterial Translocation. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(2): 240-243. doi: Copy

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4.	尹军霞，林德荣. 肠道菌群与疾病 [J]. 生物学通报, 2004; 39(3)∶26.
5.	董永绥. 肠道菌群失调、内毒素与小儿胃肠功能障碍 [J]. 中国实用儿科杂志, 2001; 16(1)∶5.
6.	Besselink MG， Timmerman HM， Buskens E, et al. Probiotic prophylaxis in patients with predicted severe acute pancreatitis (PROPATRIA): design and rationale of a doubleblind, placebocontrolled randomised multicenter trial [J]. BMC Surg, 2004; 4(1)∶12.
7.	吴国豪. 肠道屏障功能 [J]. 肠外与肠内营养, 2004; 11(1)∶44.
8.	李志军, 汤日波, 张万祥. 肠道屏障功能损害与SIRS／MODS的发生及其防治 [J]. 中国危重病急救医学, 2000; 12(12)∶766.
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10.	Choudhry MA, Rana SN, Kavanaugh MJ. Impaired intestinal immunity and barrier function: a cause for enhanced bacterial translocation in alcohol intoxication and burn injury [J]. Alcohol, 2004; 33(3)∶199.
11.	常建星.全身炎症反应综合征与肠屏障的损害 [J]. 国外医学·外科学分册, 2004; 31(3)∶158.
12.	张良成. 创伤和失血性休克后肠道屏障功能不全及其与MODS发生的关系 [J]. 国外医学·麻醉学与复苏分册， 2001； 22（4）∶237.
13.	Berg RD, Garlington AW. Transplantation of certain indigenous from the gastrointerstinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model [J]. Infect Immun, 1979; 23(2)∶403.
14.	石刚. 肠道黏膜屏障的损伤与保护 [J]. 肠外与肠内营养, 2004; 11(1)∶61.
15.	DeSouza DA, Greene LJ. Intestinal permeability and systemic infections in critically ill patients: effect of glutamine [J]. Crit Care Med, 2005; 33(5)∶1125.
16.	Ding LA, Li JS. Gut in diseases: physiological elements and their clinical significance [J]. World J Gastroenterol, 2003; 9(11)∶2385.
17.	Steinberg SM. Bacterial translocation: what it is and what it is not.
18.	Luyer MD, Buurman WA, Hadfoune M, et al. Strainspecific effects of probiotics on gut barrier integrity following hemorrhagic shock [J]. Infect Immun, 2005; 73(6)∶3686.
19.	郑跃杰, 段恕诚. 微生态失衡与内源性感染 [J]. 中国实用儿科杂志, 2003; 18(5)∶302.
20.	Lichtman SM. Bacterial [correction of baterial] translocation in humans [J]. J Pediatr Gastroenterol Nutr, 2001; 33(1)∶1.
21.	赵光侠. 胃肠道细菌移位、胃液菌群变化与全身炎症反应综合征 [J]. 小儿急救医学, 2003; 10(3)∶184.
22.	Stefanov CS, Boyadzhiev NP, Uchikov AP. Enteral nutrition in sepsis patients.
23.	Kell MR, Barry BD, Redmond HP. Systemic inflammatory response syndrome: a new direction?.

1. [J]. Am J Surg, 2003; 186(3)∶301.
2. [J]. Folia Med (Plovdiv), 2005; 47(1)∶11.
3. [J]. Ir J Med Sci, 2003; 172(1)∶7.
4. 尹军霞，林德荣. 肠道菌群与疾病 [J]. 生物学通报, 2004; 39(3)∶26.
5. 董永绥. 肠道菌群失调、内毒素与小儿胃肠功能障碍 [J]. 中国实用儿科杂志, 2001; 16(1)∶5.
6. Besselink MG， Timmerman HM， Buskens E, et al. Probiotic prophylaxis in patients with predicted severe acute pancreatitis (PROPATRIA): design and rationale of a doubleblind, placebocontrolled randomised multicenter trial [J]. BMC Surg, 2004; 4(1)∶12.
7. 吴国豪. 肠道屏障功能 [J]. 肠外与肠内营养, 2004; 11(1)∶44.
8. 李志军, 汤日波, 张万祥. 肠道屏障功能损害与SIRS／MODS的发生及其防治 [J]. 中国危重病急救医学, 2000; 12(12)∶766.
9. Demling RH. The clinical relevance of defining the mechanism for altered gut permeability in a “twohit”model of injury and infection [J]. Crit Care Med, 2004; 32(11)∶2356.
10. Choudhry MA, Rana SN, Kavanaugh MJ. Impaired intestinal immunity and barrier function: a cause for enhanced bacterial translocation in alcohol intoxication and burn injury [J]. Alcohol, 2004; 33(3)∶199.
11. 常建星.全身炎症反应综合征与肠屏障的损害 [J]. 国外医学·外科学分册, 2004; 31(3)∶158.
12. 张良成. 创伤和失血性休克后肠道屏障功能不全及其与MODS发生的关系 [J]. 国外医学·麻醉学与复苏分册， 2001； 22（4）∶237.
13. Berg RD, Garlington AW. Transplantation of certain indigenous from the gastrointerstinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model [J]. Infect Immun, 1979; 23(2)∶403.
14. 石刚. 肠道黏膜屏障的损伤与保护 [J]. 肠外与肠内营养, 2004; 11(1)∶61.
15. DeSouza DA, Greene LJ. Intestinal permeability and systemic infections in critically ill patients: effect of glutamine [J]. Crit Care Med, 2005; 33(5)∶1125.
16. Ding LA, Li JS. Gut in diseases: physiological elements and their clinical significance [J]. World J Gastroenterol, 2003; 9(11)∶2385.
17. Steinberg SM. Bacterial translocation: what it is and what it is not.
18. Luyer MD, Buurman WA, Hadfoune M, et al. Strainspecific effects of probiotics on gut barrier integrity following hemorrhagic shock [J]. Infect Immun, 2005; 73(6)∶3686.
19. 郑跃杰, 段恕诚. 微生态失衡与内源性感染 [J]. 中国实用儿科杂志, 2003; 18(5)∶302.
20. Lichtman SM. Bacterial [correction of baterial] translocation in humans [J]. J Pediatr Gastroenterol Nutr, 2001; 33(1)∶1.
21. 赵光侠. 胃肠道细菌移位、胃液菌群变化与全身炎症反应综合征 [J]. 小儿急救医学, 2003; 10(3)∶184.
22. Stefanov CS, Boyadzhiev NP, Uchikov AP. Enteral nutrition in sepsis patients.
23. Kell MR, Barry BD, Redmond HP. Systemic inflammatory response syndrome: a new direction?.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Study about Bacterial Translocation

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