Expression and Clinical Significance of Melanoma Antigen-3 Gene in Rectal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI Xin ming ¹ , TAO Kaixiong ¹ , WANG Guobin ¹ , ZHANG Ning ¹ , WU Xiangbo ¹ , ZHANG Jinghui ² , TIAN Yuan. ²

Department of General Surgery, Wuhan Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China;

Corresponding author：

Keywords：

Rectal cancer Melanoma antigen-3 gene Gene expression

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【Abstract】ObjectiveTo detect the expression of melanoma antigen-3 gene (MAGE-3) in rectal cancer and explore its relationship with the clinical pathology of rectal cancer and clinical significance in immune therapy.
MethodsThe expressions of MAGE-3 in tumor tissue, para-tumor tissue of （5±1） cm from border of tumor tissue, tissue of resection border and polypus were detected by RTPCR.
ResultsMAGE-3 expression was positive in 14 of 33(42.42%) samples of rectal cancer, 6 of 33 (18.18%) of paratumor tissue, and 5 of 33 (15.15%) of resection border tissue respectively. No MAGE-3 was detected in 3 polypi. The positive rate of MAGE-3 in tumor tissue was significantly higher than that of the paratumor and resection border tissue (P＜0.05). The expression of MAGE-3 was not related to age, gender, histological type, metastasis to lymph nodes, and Dukes stage (P gt;0.05).
Conclusion MAGE-3 protein may be used as a target of immunotherapy for rectal cancer and an index for follow-up and screening of rectal cancer.

Citation： LI Xin ming,TAO Kaixiong,WANG Guobin,ZHANG Ning,WU Xiangbo,ZHANG Jinghui,TIAN Yuan.. Expression and Clinical Significance of Melanoma Antigen-3 Gene in Rectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(3): 308-310下转320. doi: Copy

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4. [Ｊ]. Nihon Rinsho Meneki Gakkai Kaishi, 1997； 20(2)∶95.
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6. [Ｊ]. Arch Pathol Lab Med, 1998； 122(6)∶551.
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16. Gerhardt A, Usener D, Keese M, et al. Tissue expression and seroreactivity of tumorspecific antigens in colorectal cancer.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression and Clinical Significance of Melanoma Antigen-3 Gene in Rectal Cancer

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