Relationship Between the Bacterial Spectrum Difference of Gallbladder Mucosa and Choledochus Bile and Clinical Prognosis of Gallstone Pancreatitis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Gang , SUN Xuejun , REN Hong , SHI Jingsen.

Lab of Hepatobiliary Surgery, The First Affiliated Hospital, Medical College of Xi’an Jiaotong University, Xi’an 710061， China;

Corresponding author：

Keywords：

Gallstone pancreatitis Bacterial culture Antibiotic Microorganism drug sensitivitytest

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【Abstract】ObjectiveTo study the relationship between the bacterial spectrum difference of gallbladder mucosa and choledochus bile and clinical prognosis of gallstone pancreatitis.
MethodsA synchronic bacterial culture and drug sensitivity test were carried out on 48 patients with gallstone pancreatitis.
ResultsThe cases of positive gallbladder mucosa and choledochus bile were 13 (27.1%) and 31 (64.6%) respectively. The cases of double positivity were 12 (25.0%). The cultural strains of gallbladder mucosa and choledochus bile were significantly different. Some strains were only found in choledochus bile，whereas in gallbladder mucosa L-form bacteria predominated.
ConclusionThe most common causative strain of gallstone pancreatitis is Bacterium coli. The drug-resistant strain emerges maybe due to bacterium immigration and delitescence in gallbladder mucosa. L-form bacteria should be considered when using antibiotics, because L-form bacteria have close relationship with the prognosis of gallstone pancreatitis.

Citation： LIU Gang,SUN Xuejun,REN Hong,SHI Jingsen.. Relationship Between the Bacterial Spectrum Difference of Gallbladder Mucosa and Choledochus Bile and Clinical Prognosis of Gallstone Pancreatitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(4): 386-389. doi: Copy

1.	Schmid SW, Uhl W, Friess H, et al. The role of infection in acute pancreatitis [Ｊ]. Gut, 1999; 45(2)∶ 311.
2.	Chang L, Lo SK, Stabile BE, et al. Gallstone pancreatitis: a prospective study on the incidence of cholangitis and clinical predictors of retained common bile duct stones [Ｊ]. Am J Gastroenterol, 1998; 93(4)∶527.
3.	Arendt T. Bileinduced acute pancreatitis in cats. Roles of bile, bacteria, and pancreatic duct pressure [Ｊ]. Dig Dis Sci， 1993; 38(1)∶39.
4.	Arendt T， Nizze H， Liebe S, et al. Does bile of patients with acute gallstone pancreatitis cause pancreatic inflammatory lesions? A study of the pancreatic toxicity of choledochal secretions collected at ERCP [Ｊ]. Gastrointest Endosc, 1999; 50(2)∶209.
5.	Csendes A, Burdiles P, Maluenda F, et al. Simultaneous bacteriologic assessment of bile from gallbladder and common bile duct in control subjects and patients with gallstones and common duct stones [Ｊ]. Arch Surg, 1996; 131(4)∶389.

1. Schmid SW, Uhl W, Friess H, et al. The role of infection in acute pancreatitis [Ｊ]. Gut, 1999; 45(2)∶ 311.
2. Chang L, Lo SK, Stabile BE, et al. Gallstone pancreatitis: a prospective study on the incidence of cholangitis and clinical predictors of retained common bile duct stones [Ｊ]. Am J Gastroenterol, 1998; 93(4)∶527.
3. Arendt T. Bileinduced acute pancreatitis in cats. Roles of bile, bacteria, and pancreatic duct pressure [Ｊ]. Dig Dis Sci， 1993; 38(1)∶39.
4. Arendt T， Nizze H， Liebe S, et al. Does bile of patients with acute gallstone pancreatitis cause pancreatic inflammatory lesions? A study of the pancreatic toxicity of choledochal secretions collected at ERCP [Ｊ]. Gastrointest Endosc, 1999; 50(2)∶209.
5. Csendes A, Burdiles P, Maluenda F, et al. Simultaneous bacteriologic assessment of bile from gallbladder and common bile duct in control subjects and patients with gallstones and common duct stones [Ｊ]. Arch Surg, 1996; 131(4)∶389.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relationship Between the Bacterial Spectrum Difference of Gallbladder Mucosa and Choledochus Bile and Clinical Prognosis of Gallstone Pancreatitis

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