【Abstract】Objective To study the changes of insulin-like growth factor-1(IGF-1) in serum of patients with obstructive jaundice.
Methods The clinical data of 20 patients with obstructive jaundice were collected and the measurement of serum TNFα,ALT, ALP, endotoxin and IGF-1 were performed.
Results The serum IGF-1 in obstructive jaundice was significantly lower than that in gallbladder stone(P＜0.01), while endotoxin, TNF-α, ALT，ALP and TB were higher(P＜0.01). After the biliary duct obstruction was removed, the serum IGF1 in obstructive jaundice was significantly higher than that before operation and serum endotoxin， TNF-α, ALT， ALP and TB were significantly lower than that before operation(P＜0.01). A significant negative correlation was found between serum IGF-1 and serum endotoxin in benign obstructive jaundice(r=-0.761, P＜0.01).
ConclusionIn obstructive jaundice, endotoxemia can affect the secretion of IGF-1 from liver. IGF-1 can be used as an index to judge the liver function in obstructive jaundice.
Citation：
YIN Lanning,HOU Zhijun,SONG Ailin,KOU Zhimin.. Changes of InsulinLike Growth FactorSTHZ1 in Serum of Patients with Obstructive Jaundice. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2005, 12(4): 349-350. doi:
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Moller S, Becker U. Insulinlike growth factor 1 and growth hormone in chronic liver disease [Ｊ]. Dig Dis， 1992; 10(4)∶239.
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Sheppard MS, Minuk GY, Bhaumick B, et al. Insulinlike growth factors (IGF) in liver disease: differential changes of IGFⅠ and IGFⅡ [Ｊ]. Clin Invest Med, 1987; 10(2)∶49.
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Priego T, Granado M, Ibanez de Caceres I, et al. Endotoxin at low doses stimulates pituitary GH whereas it decreases IGFⅠ and IGFbinding protein in rats [Ｊ]. J Endocrinol, 200; 179(1)∶107.
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FernandezCelemin L, Pasko N, Blomart V, et al. Inhibition of muscle insulinlike growth factor Ⅰ expression by tumor necrosis factoralpha [Ｊ]. Am J Physiol Endocrinol Metab, 2002; 283(6)∶E1279.
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Katz S, Pescovitz OH, Grosfeld JL. Growth failure and decreased levels of insulinlike growth factor Ⅰ in obstructive jaundice are reversed by bile diversion [Ｊ]. J Pediatr Surg, 1991; 26(8)∶900.
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- 1. Moller S, Becker U. Insulinlike growth factor 1 and growth hormone in chronic liver disease [Ｊ]. Dig Dis， 1992; 10(4)∶239.
- 2. Sheppard MS, Minuk GY, Bhaumick B, et al. Insulinlike growth factors (IGF) in liver disease: differential changes of IGFⅠ and IGFⅡ [Ｊ]. Clin Invest Med, 1987; 10(2)∶49.
- 3. Priego T, Granado M, Ibanez de Caceres I, et al. Endotoxin at low doses stimulates pituitary GH whereas it decreases IGFⅠ and IGFbinding protein in rats [Ｊ]. J Endocrinol, 200; 179(1)∶107.
- 4. FernandezCelemin L, Pasko N, Blomart V, et al. Inhibition of muscle insulinlike growth factor Ⅰ expression by tumor necrosis factoralpha [Ｊ]. Am J Physiol Endocrinol Metab, 2002; 283(6)∶E1279.
- 5. Katz S, Pescovitz OH, Grosfeld JL. Growth failure and decreased levels of insulinlike growth factor Ⅰ in obstructive jaundice are reversed by bile diversion [Ｊ]. J Pediatr Surg, 1991; 26(8)∶900.
