Objective To evaluate the relationship between endothelin (ET) in bile and peripheral blood with systemic and hepatobiliary injury in patients with acute cholangitis of severe type (ACST).
Methods ET, ALT and total bilirubin in bile and peripheral veinous blood of 25 patients with acute cholangitis of severe type (ACST) were detected during operation, one week and two weeks after operation.
Results The contents of ET, ALT and total bilirubin were significantly lower on 7-day and 14-day after operations as compared with that during operations (Ｐ＜0.05 and Ｐ＜0.01). The concentration of ET in peripheral veinous blood paralleled with that in bile.
Conclusion This suggests that ET is tightly related with the pathologic process of ACST. So, in patients with ACST, the dynamic measurement of ET in peripheral veinous blood can be an index for judging the degree of pathological damage either to the hepatobiliary or systemic systems.
Citation：
XIAO Yongcheng,XIA Xianming,YANG Hui,et al.. DYNAMIC MEASUREMENT AND SIGNIFICANCE OF ENDOTHELIN IN BILE AND PERIPHERAL VEINOUS BLOOD IN PATIENTS WITH ACUTE CHOLANGITIS OF SEVERE TYPE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(2): 91-93. doi:
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- 1. Yanagisawa M. Anoved potent vasoconstrictor peptide produced by vasculor endothedlial cells 〔Ｊ〕. Nature, 1998; 332(1)∶411.
- 2. 肝胆管结石专题讨论纪要 〔Ｊ〕. 中华外科杂志， 1983； 21(6)∶372.
- 3. 汤健， 唐朝枢， 杨军主编. 内皮素 〔M〕. 第1版. 北京： 北京医科大学中国协和医科大学联合出版社， 1994∶401～406.
- 4. Lygidaskis DJ. Operative visk factors of cholecystectomycholedochoslomy in the eldely 〔Ｊ〕. Surg Cynecol Obetel, 1983; 157(1)∶15.
- 5. Weitzbery E, Wndberg JM, Rudohill A. Elerated plasma levels of endothelin in patients with sepsis syndrome 〔Ｊ〕. Cire Shock, 1991; 33(1)∶22.
- 6. 王福深， 王霄虹， 盛树力. 内皮素的结构及生理病理作用 〔Ｊ〕. 首都医学院学报， 1990； 11(4)∶326.
- 7. Miyoshi Y, Nakaya Y, Wakatsuki T, et al. Endothelin blocks ATPsentive K＋ channels and depolarizes smooth muscle cells of porcine coronary artery 〔Ｊ〕. Cire Res, 1992; 70(3)∶612.
