• Intensive Care Unit,Affiliated Tumor Hospital of Guangzhou Medical College.Guangzhou,Guangdong,510095,ChinaCorresponding author:LIANG Zong-an,E-mail:liangzongan@ hotmail.corn;
LIANG Zongan, Email: liangzongan@hotmail.com
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Objective  To investigate the effects of immune—enhancing enteral nutritioin therapy on the inflammatory reaction and immune function in the rats of ventilation-induced lung injury.Methods  Fourty rats were divided into four groups(EN1、EN2、SEN1、SEN2,n=10).All groups were performed mechanic ventilation and fed isocaloric enteral nutrition.EN1 group:tidal Volume(VT) =8 mL/kg,traditional enteral nutrition;EN2 group:VT=40 mL/kg,traditional enteral nutrition;SEN1 group:VT:8 mL/kg,immune-enhancing enteral immunonutrition;SEN2 group:VT=40 mL/kg,immune-enhancing enteral immunonutrition.Lymphocyte subsets,TNF-α,IL-6 and contents of arachidonic acid(AA)were determined at different time point(0,4,24,72 h after ventilation).Results  The levels of CD3+,CD4+,CD4+/CD8+ in SEN2 group were lower(P lt;0.05)than in EN1,EN2 and SEN1 group after 24,72 h of ventilation.The serum concentrations of TNF-α,IL-6 and AA were significantly lower in EN2 than in other three groups(P  lt;0.05).Conclusion  Immune-enhancing enteral nutrition feeding prior to machanie ventilatioin can alleriate the damage of immunological function and reduce infl ammotory responses

Citation: XIAN Lewu,LIANG Zongan. Effect of immune-enhancing enteral nutrition on inflammatory reaction and immune function in the rats of ventilation-induced lung injury. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(6): 455-458. doi: Copy

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