目的：通过对首例甲型H1N1流感密切接触者临床医学观察发现二代患者,为大规模临床医学观察积累经验和参考。方法：对首例甲型H1N1流感患者密切接触者115例的临床医学观察资料进行回顾性分析。结果：115例密切接触者中,有6人出现不同程度咽充血、咽部疼痛症状,其中1例为糖尿病患者、2例为高血压患者;1例左前臂疱疹,1例口腔溃疡,4例结膜充血;观察第3天1例出现精神抑郁,1例出现情绪激动;观察第4天2例多次要求提前解除隔离,多例关心何时解除隔离。七日医学观察期间115例密切接触者均无咽痛、咳嗽、鼻塞等症状,体温均正常,情绪稳定,未发现二代患者。结论：对甲型H1N1流感患者的密切接触者进行临床医学观察是必要的,有助于发现二代患者,疾控中心(CDC)采样与临床医学观察和心理干预的有效结合,给传染病医学观察提供宝贵的经验和有效的工作模式。
In order to improve the management of medical technology and ensure the safety, efficiency, and economy of medical devices, we introduce the current situation and future of clinical medical engineering technology evaluation from eight aspects: evaluation standard, evaluation of technical performance, evaluation of reliability, evaluation of clinical application, evaluation of health economy, evaluation of service system, technology maturity, and human factor engineering. The evaluation of clinical medical engineering technology is still in the initial stage, and it is necessary to speed up the establishment of standardization system and evaluation criterion for all kinds of equipment evaluation.
Objective To analyze the articles published by graduate students of West China School of Medicine in Sichuan University from 2013 to 2017. Methods Outcome indicators which includes the quantity of papers, annual distribution, paper category and papers cited by SCI were analyzed through bibliometrics methods. Statistical analysis was performed using SPSS 18.0 software. Results From 2013 to 2017, a total of 5 490 articles were published by postgraduate students in the school as first or co-first author. The average number of publication was 2.19 per student, in which 655 postgraduate students published 3 or more articles, accounting for 26.12%. A total of 2 849 articles were cited by SCI, accounting for 51.89%. The total number of publication and proportion of SCI were growing gradually. The average impact factor of each article was 2.791 and the highest impact factor for each single article was 55.7. Students who graduated from "985 university" published more articles in total and the articles cited by SCI than those from "non-985 university". Conclusion In recent years, the quality of articles published by graduate students from West China School of Medicine in Sichuan University has been improving gradually. The articles published by students graduated from "985 university" were more cited by SCI than those from "non-985 university" .
ObjectiveTo investigate the willingness and influencing factors of clinical medicine graduate students to study abroad.MethodsFrom September 2019 to January 2020, a survey was conducted among the clinical medicine graduate students in West China School of Medicine, Sichuan University. An anonymous self-report questionnaire was used to investigate their willingness to study abroad, and the related influencing factors were analyzed.ResultsA total of 600 questionnaires were distributed, in which 518 valid questionnaires were collected. Among the 518 graduate students, 96.14% anticipated to study abroad, and 93.05% expected to subsidize the study abroad through the state-sponsored study abroad fund. The major obstacle for studying abroad for joint training was concerning the negative effects on domestic clinical work or scientific research work, resulting in failure to graduate; meanwhile, difficulty in applying was the primary obstacle for studying abroad for a doctorate.ConclusionsThere is a strong willingness for clinical medicine graduate students to study abroad. However, it is affected by graduation time and application.
当前国际形势的变化及中国经济社会的发展为生物医药产业提供了难得的历史机遇，抓住这个历史机遇，实现国内与国际、产业与市场的两个有效对接，是推动我国生物医药产业发展的关键和有效手段。为了探索国内与国际对接的有效方式，我们发起“王朝计划”，并于今年6月17日在深圳第五届中国生物产业大会上，由卫生部医药卫生科技发展研究中心与英国MRCT、武汉光谷生物产业基地及上海新生源集团公司分别签订了共同推进“王朝计划”和共建“卫生部科技中心国际临床医学基地”的战略合作协议。 “王朝计划”的核心思想是将英国领先的医药研发能力与中国巨大的市场需求相对接，实现技术和项目的双向转移。“王朝计划”有3个重要特点：① 民间发起的国际合作计划，而非政府间合作计划；② 商业合作计划，而非单纯的科技合作计划；③ 开放的合作计划，是集成技术、成果、人才、资本各种资源的计划。 为了探索产业与市场对接的有效方式，我们启动了“卫生部科技中心国际临床医学基地”的建设工作。其宗旨是利用科技手段，努力解决长期存在的产业与临床应用两张皮的问题；加快和规范生物医药技术和产品的市场推广；实现医疗技术水平和生物医药产业相互促进，共同发展。其建设思路紧紧围绕1个重点，针对2个需求，开展3项业务，实现4个目标。围绕1个重点：重点开展上市后医药技术和产品的临床研究，而不是主要承担以上市申报为目的的临床试验。与通常的CRO不同，我们的主要产出是临床研究的科研成果，而不是临床试验的申报资料。针对2个需求：① 已上市的产品或技术对开拓市场的需求；② 广大医务工作者开展科学研究，提高医疗水平的需求。开展3项业务：① 吸纳多方投入，建立临床科研基金，组织开展临床科研项目，探索既实现科研投入多元化，又确保具体的科研活动不受商业利益牵制的有效机制；② 建立针对不同疾病或症候群的临床研究数据库，实现医学知识的系统积累，产出更多的高水平科研成果，推动流行病学、循证医学和转化医学的发展；③ 将卫生技术评估体系与产业对接，完善我国医药技术和成果的评价体系，提高医药企业的技术决策能力。实现4个目标：① 做强优势技术、成果和企业；② 推动临床科技进步和技术水平提升；③ 催生新的服务产业模式；④ 是完善园区的技术孵化和产业促进体系，增强园区的招商引资能力。 “国际临床医学基地”将由卫生部科技发展中心与武汉光谷生物基地共建，在湖北省卫生厅等有关方面的支持下，实行理事会领导下的主任负责制，依托由园区直属国有企业与其他企业合资设立的专门公司进行具体运作。卫生部科技中心主要负责整体设计、宏观决策、政策支持和监督把关，不参与实体公司的股份和单纯市场运作。“王朝计划”和“国际临床医学基地”既密切相关，相互促进，又各有独立的业务发展方向。这两项事业都是全新的探索，要走的路还很长，还有许多困惑和挑战，都需要政府、企业、临床医疗机构和投资机构等多方面的大力支持。为了生物技术能向信息技术那样，真正实现全方位、大规模的产业化，真正全面改变我们的世界和生活，让我们共同努力！ 收稿日期：2011–12–06 本文编辑：杜亮
Modern medical education faces multiple challenges, and there is a gap between the social needs and the methods of cultivating medical talents. The current undergraduate education in clinical medicine is subject centered, and the traditional model is difficult to cultivate students’ clinical abilities, practical skills, and research thinking effectively. Therefore, West China Hospital/West China School of Medicine of Sichuan University has proposed a new education model of “Four-Early and Three-Entry”, aiming to cultivate students’ professional ethics, clinical abilities, and scientific research innovation abilities through early clinical practice, scientific research participation, and social integration. This article will introduce the practice and preliminary results of the “Four-Early and Three-Entry” model, aiming to provide effective ways to improve the quality of medical undergraduate education and cultivate more comprehensive medical professionals.
Objective To compare the survey results of the 8-year program students of clinical medicine discipline before and after the implementation of system-based integrated course reform, to provide feedback for system-based integrated course reform. Methods The questionnaire survey was continuously conducted for 2 years among the 8-year program students in grade of 2005 and 2006, so as to investigate their attitudes towards the integrated clinical courses, then relevant improvement of teaching measures were performed according to their feedback, and the difference of teaching effects between those 2 years was finally compared. Results A total of 79 students in grade 2005 and 78 students in grade 2006 were investigated. The baseline data were matched between the 2 grades. The results of statistical analysis showed that, the overall cognition (χ2=32.924, Plt;0.000 1) and assessment (t=−2.900, P=0.004) of integrated courses among students in grade 2006 got more improved in comparison with the students in grade 2005, and more students tended to select integrated courses, but there was no statistical difference. Conclusion Although system-based integrated clinical course as a new thing has its limitations, the reform idea and direction are still approved by students, so it is worth popularizing.
We described our understanding of EBM, the ‘three principles＇ and ‘five steps＇ to practice it. EBM is an embodiment of human moral rule and axiom in clinical medicine; it is an advanced clinical model and medical practical methodology; it results from a basis of developed and perfected clinical research methodology, best evidence database, information technology. We also discussed the relationship between EBM and traditional Chinese medicine （TCM） modernization. The definition of modernization of TCM was suggested as scientifical standardization and internationalization. TCM theory in fact is not a basic but a clinical practice theory. EBM model should become the standard model of TCM practice to accelarate the standardization of TCM diagnostic technique and therapy. The key is not try to explain TCM theories with modern medical theroies, but work out common effectiveness evaluation criteria. Only when the effectiveness is intemationally acknowledged, can TCM be internationalized.