摘要:目的：探讨成都地区体检人群中丙氨酸氨基转移酶（ALT）升高率与其升高的相关因素,为正确分析引起ALT升高的原因提供相关依据。方法:以参与体检的8734名体检人群为研究对象,收集身高、体重、血压、丙氨酸氨基转移酶、空腹血糖、高密度脂蛋白、低密度脂蛋白、总胆固醇、甘油三酯、血清HBsAg、脂肪肝及胆石症等相关资料进行分析。结果:在全部体检人群中,ALT升高率为1011%,男性ALT升高率为13.70%,女性ALT升高率为6.30%,男性明显高于女性（Plt;0001）；ALT升高组的年龄均数小于ALT正常组（Plt;0001）；在ALT升高的受检者中,脂肪肝、高脂血症、肥胖、糖尿病、胆囊结石、饮酒及乙肝等患病率均高于ALT正常组受检者（Plt;005）。结论:脂肪肝、糖脂代谢紊乱及乙肝是体检人员ALT升高的主要原因；男性和低龄也是体检者ALT升高的危险因素。Abstract: Objective: To investigate the prevalence and relative factors of elevated serum alanine aminotransferase(ALT) levels and providescientific bases for its causes analysis in physical examination people in Chengdu. Methods: Subjects who received medical examination in physical examination center of west China hospital were screened in this study. The information of height, body weight, blood pressure, serum ALT, fasting plasma glucose, highdensity lipoprotein cholesterol, lowdensity lipoprotein cholesterol, total cholesterol, triglyceride, hepatitis B surface antigen (HBsAg) statue, fatty liver and cholelithiasis were collected and analyzed. 〖WT5”HZ〗Results:〖WT5”BZ〗 A total of 8734 cases were included in this study. The total prevalence of elevated ALT was observed in 1011%, including 137% in man and 63% in woman, and this difference between man and woman was statistic significant (P＜0001). The mean age of ALT elevated group was obvious lower than that of normal ALT group (P＜0001). Interesting, the occurrence rates of fatty liver, hyperlipidemia, obesity, diabetes,gallstones, drinking and positive hepatitis B surface antigen in ALT elevated group were all significant higher than that in normal ALT group (P＜005). Conclusion: Fatty liver, glyeolipid metabolism disorder, and hepatitis B were main reasons of elevated ALT. Male and young cases were both high risk of elevated ALT in this study.
ObjectiveTo survey on the health-related knowledge in cadres, in order to regulate corresponding health management strategies. MethodsQuestionnaires were used to collect data of 816 examinees who accepted physical examination in our hospital between June and July 2014. Factors affecting health examination service efficiency were identified to formulate a scale and a questionnaire for surveying examinees' preparatory status before examination and general information. The correlation between their preparatory status and demographic features was analyzed. The results were used to support management decision-making. ResultsOf the 816 examinees, 396 had a score over 6 points (48.5%, well prepared) and 420 had 6 points or below (51.5%, poorly prepared). The male preparation before examination was significantly poorer than the female (χ2=4.318, P=0.038). ConclusionWe should strengthen the knowledge education for cadres before physical examination.
【摘要】 目的 探讨如何通过流程优化应对体检高峰期。 方法 通过体检高峰期流程优化前后（2008年与2010年）的管理成效对比，评估高峰期流程控制的有效性。 结果 体检高峰期流程优化后，平均候检人数由8人下降至3人、平均侯检时间由11.9 min下降至4.2 min，平均体检时间由175 min下降至130 min。体检者对体检环境、服务态度和服务质量的满意度均高于优化前，差异有统计学意义（Plt;0.05）。 结论 通过流程优化与控制有效地缓解了高峰期体检人员等候时间过长现象，极大地提高了体检者满意度，保障了健康体检工作质量。【Abstract】 Objective To explore how to cope with the peak flow of physical examination through the process optimization. Methods Evaluate the utility of the process control at physical examination peak flow, by contrasting the management effect before and after the physical examination peak flow optimization (2008 and 2010). Results After the process optimization in peak flow, the average number of people waiting to be checked is down to 3 from 8, the consumers′ satisfaction with the medical environment, service attitude and the service quality is higher than before optimization, the difference was significant (Plt;0.05). Conclusion Through the process optimization and control effectively relieve the time for waiting to be examined, greatly enhance the satisfaction of people who take physical examinations and ensure the quality of physical examination.
ObjectiveTo investigate the antibody concentration and immune status of intensive care medical staff after vaccination against COVID-19. Methods From October 1, 2021 to February 28, 2022, the serial numbers of 47 hospitals were randomly selected by cluster stratified random sampling method. Blood samples were collected from 192 medical staff in intensive care department who had received inactivated novel coronavirus vaccine in 7 hospitals. The antibody concentration was determined by chemiluminescence method to find the antibody rule. Logistic regression analysis was used to determine the related factors affecting the production of antibodies. ResultsTotal antibody concentration of 192 blood samples was 23.25 (5.09, 270.22), IgG concentration was 0.94 (0.15, 4.48), IgM concentration was 0.05 (0.03, 0.12). Logistic regression analysis showed that the total antibody concentration might be related to gender and age, and the IgG concentration was significantly related to whether the third injection was administered. One hundred and twenty-seven people received 2 doses of inactivated vaccine, and the positive rate of IgG was the highest within 1 to 2 months, and decreased significantly after 3 months. The positive rate of IgG antibody was 95.4% within 60 days after receiving 3 doses of vaccine, 70% within 1 month after receiving the third dose of vaccine, and 100.0% within 1 to 2 months (P<0.05). The total antibody positive rate was 96.3% in people aged 17 to 35 years and 73.3% in people aged 36 to 58 years, showing statistical difference (P<0.05). The total antibody production rate of those who received the third dose of vaccine was 100.0%, and no severe case of COVID-19 occurred during the sampling period. Conclusions After the first, second, and third doses of COVID-19 vaccine, the total antibody concentration of the virus gradually increases to 100.0%, indicating initial immunity. However, the antibody concentration decreased gradually after 3 months of inoculation. The concentration of IgG in women is higher than that in men, and the concentration of antibody in young people is higher than that in middle-aged and elderly people during the same period.
ObjectiveTo investigate the current status of visual disability in people with opportunistic diabetes based on the physical examination center, and explore its related factors. MethodsPeople who went to West China Hospital of Sichuan University (West China Hospital district and Wenjiang hospital district) for physical examination between January 2019 and March 2020 were selected. The subjects were those who had a history of diabetes or fasting blood glucose≥7 mmol/L or glycosylated hemoglobin≥6.5%. They were divided into two groups according to visual acuity. The physical examinees with low vision were the observation group, and the physical examinees with normal vision were the control group (the number of cases was twice that of the observation group). The relevant data of the two groups were observed and compared, and the risk factors of low vision were analyzed by logistic regression. ResultsA total of 1 636 physical examinees with diabetes were included. There were 158 cases in the observation group and 316 cases in the control group. 158 cases (203 eyes) had low vision, and the incidence was 6.20% (203/3272). The main diseases leading to low vision were cataract (92 cases, 58.23%), high myopia (32 cases, 20.25%) and diabetes retinopathy (20 cases, 12.66%). Logistic regression analysis showed that the independent risk factors for low vision were age of diabetes patients, diabetes retinopathy, systolic blood pressure and glycosylated hemoglobin. ConclusionsThe incidence of low vision in diabetes population based on physical examination centers in Chengdu is low. Visual acuity examination should be strengthened for diabetes patients, especially the elderly, with diabetes retinopathy, high systolic blood pressure and glycosylated hemoglobin. Early effective prevention and treatment can reduce the damage to vision caused by diabetes.
Breathing gas carries important physiological information. Technology for detection of breathing gas has become a research focus because of the advantages of nondestructive sampling and convenient operation. Proton transfer reaction mass spectrometry (PTR-MS) plays an irreplaceable role because of the advantages of high sensitivity, fast response and good specificity. In this paper, the principle of PTR-MS is introduced first, followed by research progress of PTR-MS in the field of breathing gas detection. Factors influencing the test results are analyzed. Finally, future prospects of development for PTR-MS in the field of breathing gas detection are discussed.
【摘要】 目的 用高频超声对正常女性乳腺健康体检，探讨其在临床及乳腺普查方面的应用价值。 方法 对2006年1月－2009年12月间7 532例健康女性乳腺体检声像图进行分析，并对各年龄段的乳腺病变超声结果分布情况进行统计。 结果 共检出乳腺病变2 861例（37.98%），正常者4 671例（62.02%）。所有受检者中，囊性病变1 904例（25.28%），实性病变944 例（12.53%），混合性病变13例（0.17%），伴有副乳者692例。囊性病变及实性病变单侧多于双侧，混合性病变均为单侧。常见病中，囊性病变多于实性病变，发病年龄分布在20～30岁及31～40岁年龄段。 结论 高频超声作为女性乳腺疾病的一种常规检查，能对乳腺占位性疾病提供较为准确的诊断，对乳腺癌早期发现、早期诊断、早期治疗提供一种科学依据。【Abstract】 Objective To explore the clinical value of high-frequency sonography for normal clinical breast examination in breast screening. Methods From January 2006 to December 2009, 7 532 healthy women underwent breast sonography. The results of sonography in the individuals with different ages were statistically analyzed. Results Breast lesions were found in 2 861 cases (37.98%) and the other 4 671 were healthy. Among all of the individuals, 1 904 cases (25.28%) had cystic lesions, 944 (12.53%) had solid lesions and 13 (0.17%) had mixed lesions. There were 692 cases of accessory mammary tissue. Unilateral cystic nodules and solid nodules were more common than bilateral ones, whereas mixed nodules were usually sunilaterally. Cystic nodules were more common than solid nodules. Most common onset of breast lesions is in the individuals with the age of 20-30 and 31-40 years. Conclusion High-frequency sonography, as an examination for normal clinical breast screening provides more accurate diagnosis and early detection of breast lesions, which can provide scientific evidence for early detection, diagnosis and treatment for breast cancer.