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find Keyword "局部复发" 18 results
  • TOTAL MESORECTAL EXCISION FOR RECTAL CANCER

    Objective To introduce the surgical technique and results of total mesorectal excision (TME) for rectal cancer. Methods Reviews.Results As a result of TME, local recurrence rates have declined from 20%-30% to 3%-8%, 5-year survival rate have risen to 75%, and the rates of sphincter preservation have risen too.Conclusion Total mesorectal excision reduces the local recurrence rates and raise the survival figures after excision of rectal cancer. Patients have a high quality of life.

    Release date:2016-08-28 05:29 Export PDF Favorites Scan
  • Progress of Multidisciplinary Modality in Diagnosis and Treatment for Local Recurrence of Rectal Cancer

    Release date:2016-09-08 10:23 Export PDF Favorites Scan
  • Analysis of clinical features, treatment methods, and prognostic influence factors in patients with malignant peripheral nerve sheath tumor

    Objective To investigate the clinical features, treatment methods, and prognostic influence factors of patients with malignant peripheral nerve sheath tumor (MPNST). MethodsA retrospective analysis was conducted on 96 MPNST patients treated between January 1, 2015 and December 31, 2021. There were 46 males and 50 females, aged between 15 and 87 years (mean, 48.2 years). The tumors were located in the trunk in 50 cases, extremities in 39 cases, and head and neck in 7 cases. The maximum tumor diameter was <5 cm in 49 cases, ≥5 cm in 32 cases, with 15 cases missing data. Tumor depth was deep in 77 cases and superficial in 19 cases. The Fédération Nationale des Centres de Lutte Contre le Cancer (FNCLCC) histological grading was G1 in 9 cases, G2 in 12 cases, and G3 in 34 cases, with 41 cases missing data. There were 37 recurrent MPNST cases, 32 cases with neurofibromatosis type 1 (NF1), and 26 cases in stage Ⅳ. Postoperative adjuvant radiotherapy was administered to 25 patients, perioperative chemotherapy to 45 patients, and anlotinib-targeted therapy to 30 patients. R0 resection was achieved in 73 cases. Patients were divided into groups based on the presence or absence of NF1, and baseline data between the two groups were compared. Kaplan-Meier curves were generated to assess disease-free survival (DFS) and overall survival (OS) based on various factors (age, gender, presence of NF1, recurrent MPNST, stage Ⅳ MPNST, FNCLCC grade, R0 resection, tumor location, tumor size, tumor depth, perioperative chemotherapy, postoperative adjuvant radiotherapy, and anlotinib-targeted therapy), and differences between survival curves were analyzed using the Log-Rank test. Multivariate COX proportional hazards regression was used to identify independent prognostic factors for MPNST. Results Patients with NF1 had a significantly higher proportion of superficial tumors and lower FNCLCC grade compared to those without NF1 (P<0.05); no significant difference was found for other variables (P<0.05). Kaplan-Meier analysis showed that recurrent MPNST, stage Ⅳ MPNST, FNCLCC grade, R0 resection, perioperative chemotherapy, and anlotinib-targeted therapy were factors influencing 1-year DFS (P<0.05), while stage Ⅳ MPNST, FNCLCC grade, and perioperative chemotherapy were factors affecting 3-year OS (P<0.05). Multivariate COX proportional hazards regression analysis revealed that recurrent MPNST and high-grade FNCLCC (G3) were independent prognostic factors for 1-year DFS (P<0.05), while stage Ⅳ MPNST, superficial tumor depth, age over 60 years, postoperative adjuvant radiotherapy, and anlotinib-targeted therapy were independent prognostic factors for 3-year OS (P<0.05). Conclusion MPNST patients with NF1 tend to have more superficial tumors and lower FNCLCC grades. FNCLCC grade, R0 resection, and adjuvant therapies, including radiotherapy and anlotinib-targeted therapy, are closely associated with MPNST prognosis. Complete surgical resection should be prioritized in clinical management, along with adjuvant treatments such as radiotherapy and targeted therapy of anlotinib to improve patient outcomes.

    Release date:2024-11-13 03:16 Export PDF Favorites Scan
  • Clinical and Pathologic Factors Analysis of Postoperative Local Recurrence of Rectal Cancer

    Objective To discuss the clinicopathologic risk factors related to local recurrence of rectal cancer after radical surgery. Methods The complete clinicopathologic data of 368 patients with rectal cancer from January 2004 to April 2011 in this hospital were retrospectively analyzed by univariate and multivariate analysis methods. Results There were 73 cases suffered from local recurrence and accounted for 19.84% (73/368) of rectal cancer during the same period. Univariate analysis results showed that gender, tumor from anal margin, tumor circumference, TNM staging, histology type, vessel infiltration, tumor perforation, stomal leak, and chemoradiotherapy were associated with postoperative recurrence (P<0.05). Multivariate analysis results showed that tumor from anal margin, tumor circumference, TNM staging, histology type, vessel infiltration, tumor perforation, and chemoradiotherapy were prognostic factor for local recurrence of rectal cancer (P<0.05). Conclusions There are many factors related to postoperative local recurrence, but the most dangerous factor is vessel infiltration.

    Release date:2016-09-08 10:36 Export PDF Favorites Scan
  • Progress of breast conserving therapy in patients with multifocal/multicentric breast cancer

    ObjectiveTo discuss the feasibility and security of breast conserving surgery (BCS) in patients with multifocal/multicentric breast cancer (MMBC).MethodThe clinical trials about BCS in patients with MMBC at home and abroad in recent years were searched and reviewed.ResultsThe results of most retrospective clinical trials showed that BCS in patients with MMBC could achieve similar or at least as good results as mastectomy. However, for there were some inevitable bias in retrospective studies, the conclusion should be analyzed modestly. Two prospective multicenter randomized controlled trials, the MIAMI UK trial and the ACOSOG Z11102 trial, were still ongoing, of which results were expected to confirm these conclusions further. ConclusionsUnder the premise of mastering the indications, BCS would be a reasonable option for MMBC when incisal margin is negative and cosmetic result is satisfactory. In addition, the lack of standard classification and definition for multifocality and multicentricity increases the difficulty of the research, and the distance of the cancer foci and the ratio of tumor to breast volume in patients with MMBC might be the key factors affecting the efficacy of BCS. Therefore, more rational-designed prospective studies and accurate subgroup analysis are expected to provide impelling evidence for application of BCS in patients with MMBC.

    Release date:2021-04-25 05:33 Export PDF Favorites Scan
  • Current Status of Therapy for Local Recurrence of Rectal Cancer

    Release date:2016-09-08 10:23 Export PDF Favorites Scan
  • Reoperation for Local Recurrence of Rectal Cancer(Analysis of 56 Cases)

    Objective To approach the surgical therapeutic efficacy of local recurrence of rectal cancer. Methods Fifty-six patients with local recurrence of rectal cancer suffered from reoperation from January 2003 to January2011 in this hospital were collected. Chi-square test was performed to analyze the complete excision rates of reoperation for different recurrent time after radical resection and different surgical procedures after primary radical resection of rectalcancer. The method of log-rank test was used for survival analysis of the Miles and Dixon procedure. Results ①The opera-tion time and intraoperative bleeding of reoperation for local recurrence of rectal cancer were more than those of the primary radical resection of rectal cancer (P<0.05). ②The complete resection rate of the local recurrence of rectal cancer in 5 years after primary radical resection of rectal cancer was higher than that of the local recurrence of rectal cancer within 2 years after primary radical resection of rectal cancer, and the difference was statistically significant (P<0.01). ③The complete resection rate of the local recurrence of rectal cancer of the technique of Dixon in the primary radical resection of rectal cancer was higher than that of Miles, and the difference was statistically significant (P<0.05). ④The median survival time and 2-year survival rate and 5-year survival rate of the technique of Dixon in the reoperation were longer or higher than those of Miles, and the differences were statistically significant (P<0.05). Conclusions Surgical procedure and postoperative recurrence time after primary operation can both influence complete excision rate of reoperation for local recurrence of rectal cancer. And reoperation for local recurrence of rectal cancer can prolong the survival time.

    Release date:2016-09-08 10:23 Export PDF Favorites Scan
  • Experience of Application of Total Mesorectal Excision Technique Treating Middle or Low Rectal Cancer

    目的 探讨全直肠系膜切除术(total mesorectal excision,TME)在治疗中低位直肠癌中的技术操作与效果。方法 对47例应用TME技术治疗的中低位直肠癌患者的临床资料进行回顾性分析。结果 27例行低位前切除术,20例行腹会阴联合切除术(Miles术),全部病例均顺利完成手术并出院,平均出血量250 ml; 术后发生吻合口漏2例; 术后随访0.5~3年,局部复发5例,因肝转移死亡2例。结论 应用TME技术治疗中低位直肠癌有其适应证,术中须遵循其操作规范,同时应注意采取适当的措施预防吻合口漏。

    Release date:2016-09-08 11:07 Export PDF Favorites Scan
  • 氟尿嘧啶缓释颗粒植入食管癌瘤床对食管癌根治术后局部复发的影响

    目的 观察氟尿嘧啶缓释颗粒瘤床植入对食管癌根治术后局部复发的疗效和预后影响。 方法 纳入2009年1~12月期间重庆三峡中心医院60例行食管癌根治术患者,按其治疗方法分为试验组和对照组两组,每组30例。试验组男24例、女6例,年龄(62.00±7.70)岁;对照组男23例、女7例,年龄(60.20±8.20)岁。试验组患者术中在瘤床植入氟尿嘧啶缓释颗粒300 mg,对照组不植入任何物质。比较两组患者临床结果差异。 结果 两组患者术后主要并发症发生率差异无统计学意义(P>0.05),试验组术后复发时间较对照组显著延长(P<0.05)、试验组术后复发病灶大小及复发病灶的个数较对照组显著减少(P<0.05);两组患者1年生存率差异无统计学意义,但试验组患者2年及3年生存率显著高于对照组(P<0.05),试验组中位生存时间较对照组显著延长[(29.2±1.9)月 vs. (23.4±1.4)月,P<0.05] 。 结论 食管癌术中瘤床植入氟尿嘧啶缓释颗粒能延缓肿瘤复发时间、提高食管癌患者2年及3年生存率,延长患者中位生存时间,而不增加术后并发症的发生,是一种安全、有效的局部化疗方法。

    Release date:2016-08-30 05:47 Export PDF Favorites Scan
  • Research Progress of Preoperative Radiotherapy for Rectal Cancer

    Objective To summarize the current advancement of preoperative radiotherapy for rectal cancer. Methods Relevant literatures about current advancement of preoperative radiotherapy for rectal cancer published domesticly and abroad recently were collected and reviewed. Results The lower local recurrence rate and longer disease-free survival time were observed in preoperative radiotherapy, compared with postoperative radiotherapy for rectal cancer. The recurrence rate was higher in short-course radiotherapy, compared with conventionally radiotherapy for stageⅢrectal cancer, but there was no significant difference for stageⅡrectal cancer. The biology molecular such as p53, CEA, Cox-2, EGFR, and VEGF had shown to be radiosensitive. Conclusions The proposal of preoperative radiotherapy for rectal cancer, could be prone to conventionally radiotherapy. There are more screening targets for preoperative radiotherapy in extensive exploration of diverse radiosensitivity. Biology molecular, developed gene expression profiling, and gene chips for rectal cancer may contribute to the individualization treatment.

    Release date: Export PDF Favorites Scan
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