This study aims to explore the potential of polyaspartic acid grafted dopamine copolymer (PAsp-g-DA) chelated Fe3+ for magnetic resonance imaging (MRI) visual photothermal therapy. Polyaspartic acid grafted copolymer of covalently grafted dopamine and polyethylene glycol (PAsp-g-DA/PEG) was obtained by the ammonolysis reaction of poly succinimide (PSI), and then chelated with Fe3+ in aqueous solution. The relaxivity in vitro, magnetic resonance imaging enhancement in vivo and photothermal conversion effect at 808 nm were investigated. The results showed that polymeric iron coordination had good near-infrared absorption and photothermal conversion properties, good magnetic resonance enhancement effect, and good longitudinal relaxation efficiency under different magnetic field intensities. In summary, this study provides a new magnetic resonance visual photothermal therapeutic agent and a new research idea for the research in related fields.
Lifestyle medicine is an emerging medical specialty of 20-year-history. It is more cost effective and environmentally friendlier in managing chronic health conditions of individuals and populations than the conventional allopathic medicine. By summarizing the development, implementation and prospects of lifestyle medicine in America, this paper aims to contribute to the advancement of lifestyle medicine in China.
Objective To improve surgical results, the experience of surgical management of Ebstein anomaly in 36 cases is reported and reviewed. Methods Surgical procedures included tricuspid valve replacement (6 cases), Danielson’s operation (28 cases), Carpentier’s operation (2 cases), among them, there were 5 cases of ablation of right atrioventricular accessory pathway. Results Four patients died early after operation in the hospital, 3 from right heart failure (1 case of tricuspid valve replacement and 2 cas...
BugsXLA is a Microsoft Excel add-in that facilitates Bayesian analysis of GLMMs and other complex model types by providing an easy to use interface for the BUGS package. BugsXLA macro is of good compatibility, ease to operation, smoothly running, low memory cost, and ease for data entry, extraction, and storage compared with other software which can calling BUGS to perform network meta-analysis currently. BugsXLA macro also integrates data storage and calculation. However, its function of plot drawing is very simple and only draws the density plot nowadays; Moreover, the function for calling WinBUGS is mature while is premature for calling OpenBUGS.