Abstract To observe the effect of fibroblast growth factor (FGF) on wound healing, 50 mice were divided into 5 groups. On the back of every mouse, 2 wounds were made by operative cuts, one for experiment and the other for control. The wounds of the experimental group were covered with 0.5ml FGF solution (contented FGF 300 μg/ml, heparin 100 μg/ml), whereas the wounds of the control group were covered with 0.5ml 0.9% NaCl solution. All of the wounds were dressed by sterilized gauze, and received the same treatment once a day. After 1,3,5,7,10 days, the mice in every group were sacrificed and the tissues of the wounds were collected and prepared for microscopic examination. The results showed that the capillaries and fibroblasts in the experimental group were markedly increased and reached the peak 2～3 days earlier than those in the control group. It was suggested that FGF promoted the formation of granulation tissue and the wound healing.
目的 探讨胃嗜酸性肉芽肿的诊断、误诊原因和治疗方法。方法 对14例胃嗜酸性肉芽肿的临床资料进行回顾性分析。结果 全部病例均有上腹疼痛和返酸史； 伴溃疡形成11例，穿孔4例，上消化道出血3例； 术前行胃镜检查2例，X线钡餐透视检查6例，无1例获确诊； 其余病例亦全部误诊为胃溃疡或癌肿。结论 胃镜多部位取材，特别是在溃疡与周边粘膜移行处，采取挖掘式取材，能减少误诊率； 胃大部切除术是主要的治疗方法。
ObjectiveTo investigate clinical value of magnetic resonance imaging (MRI) in differentiating xanthogranulomatous cholecystitis (XGC) with gallbladder cancer (GBC). MethodsMRI data of 7 patients with XGC and 13 patients with GBC proved by surgery and pathology were analyzed retrospectively. The main contents of the observation included:①Maximum thickness of gallbladder wall; ②Diffuse thickening or localized thickening of gallbladder wall; ③Enhancement pattern (uniform or nonuniform) of gallbladder wall; ④Gallbladder wall sandwiches enhancement; ⑤Gallbladder wall nodules; ⑥Completeness of gallbladder mucosa lines; ⑦Obstruction of biliary tract; ⑧Calculus in gallbladder or bile duct; ⑨Involvement of adjacent liver; ⑩Definition of surrounding fat layer; Lymphadenopathy. ResultsIn above 11 MRI comparing features, these features such as the gallbladder wall sandwiches enhancement, the gallbladder wall nodules, the completeness of gallbladder mucosa lines, the biliary obstruction, and the lymphadenopathy were statistically significant between the XGC and the GBC (P < 0.05), while the rest features such as the maximum thickness of gallbladder wall, the type of gallbladder wall thickening, the gallbladder wall enhancement pattern, the calculus in gallbladder or bile duct, the involvement of adjacent liver, and the definition of surrounding fat layer were not statistically significant between the XGC and the GBC (P > 0.05). ConclusionMRI has important values in differentiating XGC with GBC.
目的 探讨面部烧伤后肉芽创面移植自体大张中厚皮的可行性。 方法 回顾性分析2002年1月－2012年4月收治的27例面部烧伤后肉芽创面进行自体大张中厚皮移植手术患者的临床资料。术中用手术刀刮除肉芽组织至基底层，用取皮鼓或电动取皮刀取患者大腿或者腹部大张中厚皮，移植于受皮区，术后5 d左右打开敷料半暴露或暴露。 结果 27例手术患者中24例大张中厚皮全部成活，3例大部分成活，再次补植皮后愈合。患者创面愈合后外形丰满，皮肤弹性较好，表情丰富。20例随访1～5年，患者面部外观良好，2例发生小口畸形，2例眼睑轻中度外翻，分别行整形手术后改善。 结论 面部烧伤后肉芽创面移植大张中厚皮可获得较满意的治疗效果，可在临床推广使用。