ObjectiveTo investigate the feasibility and safety of percutaneous transhepatic choledochoscopic lithotripsy (PTCSL) in the treatment of recurrent type Ⅱa hepatolithiasis.MethodsAll of 293 patients with recurrent type Ⅱa hepatolithiasis admitted to the Second Affiliated Hospital of Chongqing Medical University from December 2010 to December 2017 were collected retrospectively, 82 of whom were treated with the PTCSL (PTCSL group), 211 of whom were treated with traditional open surgery (open group). The patients were matched according to the ratio of 1∶1 by using the method of propensity score matching, then the patients were compared after matching.ResultsA total of 59 pairs were successfully matched, that was, there were 59 patients in the PTCSL group and open group, respectively. Compared with the open group, the PTCSL group had the similar conditions such as the gender, age, preoperative Child-Pugh classification, and times of previous biliary operations, etc. (P>0.050). There was no perioperative death in both groups. There were no significant differences between the two groups in the success rate, operation time, times of operations, time of T tube removal after operation, stone residual rate, and stone recurrence rate (P>0.050). Although the hospital costs of the PTCSL group was higher than that of the open group (P<0.050), the PTCSL group had various advantages, such as less intraoperative bleeding, smaller incisional scar, shorter hospital stay and postoperative ventilation time, and lower rate of total postoperative complications (P<0.050).ConclusionsAfter learning curve, PTCSL has many advantages over traditional open surgery in treatment of recurrent type Ⅱa hepatolithiasis. PTCSL is a minimally invasive surgery, which is safe and effective.
ObjectiveTo investigate the efficacy and safety of laparoscopic cholecystectomy and common bile duct exploration(LCBDE) with biliary stent drainage or T tube drainage. MethodsThe clinical data of 68 cases of gallbladder and bile duct stones with the LCBDE by the same surgeon in our hospital from June 2008 to June 2013 were retrospectively analyzed. Twenty-two patients were treated with LCBDE and biliary stent drainage(stent drainage group), 46 patients were treated with LCBDE and T tube drainage(T tube drainage group). ResultsThe operation were successfully completed of 2 groups. The anal exhaust time, peritoneal drainage time, postoperative hospitalization time, and hospital expenses in stent drainage group were shorter or less than thoes T tube drainage group(P < 0.05). There were no significant difference in the operative time, postoperative bilirubin level, and incidences of postoperative complications between the two groups(P > 0.05). ConclusionsThe stent drainage and T tube drainage after LCBDE has its own indications. Laparoscopic common bile duct exploration and biliary stent drainage is superior to the laparo-scopic common bile duct exploration and T tube drainage.
Four hundred and eighty two paients suffering from intrahepatic bile duct stone undergoing lobectomy and segmental resection (from 1975 to 1994,9) has reported. 63% of the patient in this group underwent 1-5 operations, including different types of biliary-intestinal anastomosis (21.6%). 482 cases underwent different types of hepatectomy, including left lateral-lobetomy 321 cases (66.6%),left hemihepatectomy 80 cases(16.6%), right hemihepatectomy 19 cases (3.9%), and multiple segmental resections 39 cases (8.1%, including Ⅴ+Ⅷ 11 cases, Ⅵ+Ⅶ 28 cases). Other type hepatectomy combined with guadrate lobectomy 20 cases (4.1%). Postoperative complication rate was 10.2%, including diliary fistula. hemobilia and subdiaphragmatic and resectional surface infectioin, 85% of the patients were followed up with an excellent result of 88%. The authors emphsize that hepatic lobectomy nad segmental resection is the core of treatment and selection of operative methods depends on clinical-patholigic types of the disease.
这个题目，讨论的文章已经很多，现只就几个问题谈一些个人看法。1我国多见的肝胆管结石病有许多特点1.1西方国家极少见原因何在？除感染因素早已确定外，可能有代谢因素和基因等其它问题。1.2病变部位可在肝内各处，较多见于左外叶。可能由于肝内胆管与其下游胆管间的交角较锐，胆流相对迂滞，固形物如结晶颗粒，或异物如蛔虫尸皮等，较易停留。除左肝外，右肝后叶或某些其它部位胆管支也有相似情况。我们还发现畸形发育的右后叶肝管开口于左肝管者，其右后叶中存积结石。1.3胆道蛔虫病仍是主因结石绝大多数是含菌的，这与胆道寄生虫感染有关。除广东、香港等地人们多吃鱼生致中华肝蛭病外，大陆多数地区是由肠蛔虫引致的胆道蛔虫病，都是肠属菌脓性胆管炎。我们还发现，人蛔虫与猪蛔虫不但形态无区别，它们的组织液成分也无区别，故可能交叉感染。我国各地特别是农村几乎家家养猪，这给预防带来很大困难。1.4胆管炎很难净化结石中含菌，有残石即不断感染。结石清除后，管壁的炎性反应伴腺体中残留的细菌将长期存在，以大肠杆菌为主，据文献报道可持续半年以上，很难清除。1.5病灶长期持续慢性炎症与急性发作反复交替，管壁增厚，管腔因结石存在而扩张，管口则常狭窄。受害区的肝组织逐渐萎缩，纤维化，成为一个包括结石、病变胆管和肝组织为一体的病灶。未病的邻近胆管和肝组织常为正常。病灶可能多数，甚至全肝多处分散存在。病灶较常位于肝内亚段胆管，可能的解释是蛔虫上入肝内时，纂到最细处，不能退出，死于其中。其后虫尸腐烂断落，大部可随胆汁流出，而在亚段中的虫尸未被排出者，日后便形成病灶。
肝内、外胆管结石是常见病，治疗以外科手术为主。传统开放手术治疗疾病的同时，对患者创伤亦大。随着腹腔镜、胆道镜以及十二指肠镜技术的日益成熟，许多原本需要开腹处理的肝内、外胆管结石可用微创手术治疗，现就腹腔镜联合治疗肝内、外胆管结石的几种手术方式及其常见并发症探讨如下。1 腹腔镜胆总管探查术(laparoscopic common bile duct exploration)腹腔镜胆囊切除术(LC)初期，胆囊结石并胆总管结石一般选择分期处理，即采用LC前或后行内镜括约肌切开取石术(EST)的办法，这种分期手术避免了开腹胆总管探查，但其缺点也显而易见： 据文献\[1\]报道，即便对有经验的内镜医师而言，EST仍有5%～19%的并发症发生率和1.3%的死亡率，而且EST的应用显著增加了患者的费用; 对年轻患者尚需长期随诊观察EST后乳头括约肌的功能状况。腹腔镜胆总管探查术为处理胆囊结石并胆总管结石提供了新的选择。目前多数学者认为,EST除明确应用于术后发现胆总管结石的病例外，术前及术中发现的胆总管结石病例以行腹腔镜胆总管探查术为宜\[2\]。腹腔镜胆总管探查术有两种途径: 经胆囊管或胆总管切开探查取石，后者又根据T管放置与否分为T管引流术和一期缝合术。.......
目的比较腹腔镜下胆总管探查一期缝合与T管引流治疗肝外胆管结石的效果，总结腹腔镜下胆总管探查一期缝合的临床经验。 方法回顾性分析2010年1月至2012年12月期间于中国人民解放军总医院施行腹腔镜下胆总管探查取石的121例肝外胆管结石患者的临床资料，比较一期缝合组（n=63）与T管引流组（n=58）的手术时间、术中出血量、术后住院时间、胆瘘发生率、胆总管狭窄发生率及结石复发率。 结果2组患者均顺利完成腹腔镜手术。术后一期缝合组发生胆瘘3例，T管引流组发生1例。2组患者的术中出血量和胆瘘发生率比较差异均无统计学意义（P＞0.05），但T管引流组的手术时间和术后住院时间均较长（P=0.000）。术后所有患者获访4～36个月，平均12个月。随访期间均无复发、胆总管狭窄及死亡发生。 结论腹腔镜下胆总管探查一期缝合治疗肝外胆管结石安全而有效，并且避免了术后T管的护理，有望成为处理肝外胆管结石的主流术式。
Five thousands five hundreds and eighty two patients with cholelithasis in 46 hospitals were collected through questionnaire and analysed, of which 2 735 cases were gallstones (accounted for 48.99%),and 2 847 cases were intraand extrahepatobiliary tract stones (accounted for 51.00%). In the gallstone group, there were 487 cases (8.72%) complicated with choledocholithasis, 54 cases (1.97%) complicated with acute cholecystitis, 189 cases (6.91%) with acute cholangitis, and 215 cases (7.86%) with obstructive jaundice. In 2 847 cases with intra and extrahepatobiliary tract stones, 1 284 cases were found to be extrahepatic duct stones (23.00%), 668 cases were left intrahepatic duct stones (1.97%), 384 cases were right intrahepatic duct stones (6.88%), and 511 cases stone in both sides (9.15%); complications in this group were acute severe cholangitis 683 cases (23.99%), acute cholangitis 1 169 cases (41.06%), obstructive jaundice 431 cases (15.14%), and biliary cirrbosis 278 cases (9.76%). The operative procedure for patients with gallstones were cholecystectomy (2 697 cases), chelangioduodenostomy or cholangiojejunostomy (36 cases), and Oddi’s sphincteroplasty (7 cases); and for patients with intraand extrahepatobiliary tract stones were choledocholithotomy and T tubule drainage (2 275 cases), differecnt forms of choledochoenterostomy (534 cases), and Oddi’s sphincteroplasty (38 cases). The postoperative complicatioin rate in patients with gallstones was 1.13%, with intraand extrahepatobiiary tract stones was 14.47%, mortality of the latter was 1.62%. The authors consider that cholecystectomy should be performed in elderly patients (over 50 years) with or without symptoms, and proper choice of operative procedure for hepatobiliary tract stones is important.
Objective To evaluate the clinical value of ureteroscope in cholelithiasis treated by laparoscopic surgery. Methods The clinical data of 36 patients admitted because of hepatolithus with ureteroscope combination in laparoscopic surgery from February 2007 to September 2009 in Guidong People’s Hospital of Guangxi were analyzed retrospectively. Results In 33 cases, stones were removed once by ureteroscope in laparoscopic surgery with residual stones (in 3 cases residual stone were removed secondarily through T tube) and the other 3 cases were transferred to laparotomy forcedly due to bleeding of biliary duct and vessels of porta hepatis and tearing of bile duct. During operation, blood loss was 30-280 (94.51±54.70) ml; operation time was 110-260 (147.22±48.45) min; recovery time of bowel movement was 1-3 (2.03±0.76) d; postoperative hospitalization time was 6-13 (7.12±1.65) d (some discharged with T tube); the time of patients of T tubes pulled out was 28-45 (38.92±6.52) d. Bile leakage happened in 1 case and infection of biliary tract in 1 case, no complications such as biliary stricture or bile duct bleeding were found after operation. Conclusions Treatment of intrahepatic bile duct or a single extra-hepatic sand-like stones with ureteroscopy usage in laparoscopic surgery is feasible and less invasive. It is a minimally invasive treatment for intra- or extra-hepatic stones due to rapidly postoperative rehabilitation.