ObjectiveTo explore the dose-response relationship between coffee intake and all-cause mortality in patients with colorectal cancer, and to provide evidence-based support for improving the prognosis of patients with colorectal cancer. MethodsA comprehensive search was conducted in databases such as China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Journal Full-text Database, China Biology Medicine disc, Wanfang Data Knowledge Service Platform, PubMed, EMBase, Cochrane Library, and Web of Science for prospective cohort studies on the relationship between coffee intake and all-cause mortality in patients with colorectal cancer, up to December 2024. Literature was screened according to inclusion and exclusion criteria, and quality assessment and data extraction were performed. Data analysis was conducted using Stata 18.0 software. ResultsA total of 7 studies were included, involving 1 320 013 patients with colorectal cancer, with 11 550 all-cause deaths. The meta-analysis results showed that compared with patients with colorectal cancer who did not drink coffee, those who drank coffee had a lower risk of all-cause mortality [HR=0.66, 95%CI(0.53, 0.82), P=0.026]. There was a negative linear relationship between coffee intake and all-cause mortality in patients with colorectal cancer (χ2=24.10, P<0.01), and for each additional cup of coffee consumed daily, the risk of all-cause mortality decreased by 2%. ConclusionThere is a linear dose-response relationship between coffee intake and all-cause mortality in patients with colorectal cancer. An increase in coffee intake can reduce the risk of all-cause mortality in patients with colorectal cancer.