目的 通过分析环境空气中二氧化硫与过敏原的关联性，探讨二氧化硫在评估过敏性疾患中的作用。 方法 收集2005年1月1日－2012年12月31日绵阳市4个监测点二氧化硫浓度，及2007年7月1日－2012年12月31日的过敏性疾病患者各种过敏原的阳性百分比，采用Pearson相关分析探讨二氧化硫浓度变化对过敏原的影响。 结果 2005年－2012年绵阳市二氧化硫年平均浓度分别为（0.060 ± 0.022）、（0.054 ± 0.018）、（0.046 ± 0.012）、（0.030 ± 0.020）、（0.026 ± 0.010）、（0.035 ± 0.012）、（0.036 ± 0.008）、（0.030 ± 0.009） mg/m3。淡水鱼组合（fs34），海鱼组合（fs33），羊肉（f88），黄豆（f14），花生（f13），狗上皮（e2）与二氧化硫的Pearson相关系数分别为：0.144、0.186、0.209、0.150、0153、0.197。检验P值分别为：0.019、0.002、0.001、0.015、0.013、0.001。按α=0.05标准认为与二氧化硫存在正相关关系。而其余的尘螨组合（ds1）、普通豚草（w1）、律草（u80）、树组合（ts20）、雷菌组合（ms1）、蟑螂（i6）、屋尘（h1）、牛肉（f27）、虾（f24）、蟹（f23）、牛奶（f2）、鸡蛋白（f1）、猫毛（e1）、艾蒿（w6），按α=0.05标准，不能认为与二氧化硫存在正相关关系。 结论 环境空气二氧化硫与淡水鱼、海鲜、羊肉、大豆、花生及狗皮屑具有明确的相关性，对树组合、普通豚草、艾蒿、尘螨组合、屋尘、猫毛、蟑螂、霉菌组合、律草、鸡蛋白、牛奶、牛肉、虾、蟹等无明确的相关性。
Objective To explore decompression strategies for lateral lumbar spinal stenosis under unilateral biportal endoscopy (UBE) assistance. Methods A clinical data of 86 patients with lateral lumbar stenosis treated with UBE-assisted intervertebral decompression between September 2022 and December 2023 was retrospectively analyzed. There were 42 males and 44 females with an average age of 63.6 years (range, 45-79 years). The disease duration ranged from 6 to 14 months (mean, 8.5 months). Surgical levels included L2, 3 in 3 cases, L3, 4 in 26 cases, L4, 5 in 42 cases, and L5, S1 in 15 cases. According to Lee’s grading system, there were 21 cases of grade 1, 37 cases of grade 2, and 28 cases of grade 3 for lumbar spinal stenosis. Based on the location of stenosis and clinical symptoms, the 33 cases underwent interlaminar approach, 7 cases underwent interlaminar approach with auxiliary third incision, 26 cases underwent contralateral inclinatory approach, and 20 cases underwent paraspinal approach; then, the corresponding decompression procedures were performed. Visual analogue scale (VAS) score was used to evaluate lower back/leg pain before operation and at 1 and 3 months after operation, while Oswestry disability index (ODI) was used to evaluate spinal function. At 3 months after operation, the effectiveness was evaluated using the modified MacNab evaluation criteria. The spinal stenosis and decompression were evaluated based on Lee’s grading system using lumbar MRI before operation and at 3 months after operation. ResultsAll procedures were successfully completed with mean operation time of 95.1 minutes (range, 57-166 minutes). Dural tears occurred in 2 cases treated with interlaminar approach with auxiliary third incision. All incisions healed by first intention. All patients were followed up 3-10 months (mean, 5.9 months). The clinical symptoms of the patients relieved to varying degrees. The VAS scores and ODI of lower back and leg pain at 1 and 3 months after operation significantly improved compared to preoperative levels (P<0.05), and the indicators at 3 months significantly improved than that at 1 month (P<0.05). According to the modified MacNab evaluation criteria, the effectiveness at 3 months after operation was rated as excellent in 52 cases, good in 21 cases, and poor in 13 cases, with an excellent and good rate of 84.9%. No lumbar instability was detected on flexion-extension X-ray films during follow-up. The Lee’s grading of lateral lumbar stenosis at 2 days after operation showed significant improvement compared to preoperative grading (P<0.05). ConclusionFor lateral lumbar spinal stenosis, UBE-assisted decompression of the spinal canal requires the selection of interlaminar approach, interlaminar approach with auxiliary third incision, contralateral inclinatory approach, and paraspinal approach based on preoperative imaging findings and clinical symptoms to achieve better effectiveness.