Mast cell (MC) play a crucial role in non-allergic fundus diseases, including uveitis, diabetic retinopathy, and age-related macular degeneration. MCs can profoundly influence the pathological processes of these diseases by regulating inflammatory responses, promoting angiogenesis, and facilitating tissue remodeling through the degranulation and release of mediators such as histamine, cytokines, and enzymes. The application of MC-associated inhibitors has been shown to effectively mitigate or inhibit the progression of these pathologies, offering a promising strategy for treating ocular diseases. Understanding the current state of MC research in fundus diseases will enhance our insight into their role in the pathophysiological mechanisms of these conditions and encourage further research aimed at providing more effective treatment options for patients.
Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) is a condition characterized by episodes of apnea and hypopnea during sleep, with sleep snoring being the primary symptom. The association between OSAHS and ophthalmic diseases has long been recognized, and the potential pathogenic mechanisms have been widely investigated in recent years. It is currently believed that the alteration of inflammatory factors caused by OSAHS plays a key role, affecting vascular function and ultimately leading to the occurrence of diseases. Numerous studies have found a close relationship between OSAHS and the development of fundus diseases. Further research into the pathogenesis of OSAHS is needed in the future to enrich the conclusions regarding the relationship between OSAHS and eye diseases, with the aim of achieving prevention, treatment, and favorable prognosis for related eye conditions.