目的 探讨全凭静脉麻醉中腺苷对丙泊酚用量的影响。 方法 2011年1月－12月期间59例行择期手术的患者全凭静脉麻醉，随机分为腺苷静脉持续输注组（A组）和对照组（B组），A组患者麻醉诱导后持续输注腺苷70 μg/（kg·min），直至术毕。B组麻醉后按常规处理。比较两组患者麻醉时间、苏醒时间、瑞芬太尼用量，麻醉过程中平均动脉压（MAP）、心率，以及麻醉过程中丙泊酚的用量。同时记录使用腺苷过程中的不良反应。 结果 两组患者麻醉时间、苏醒时间、瑞芬太尼用量比较均无明显差异，无统计学意义（P＞0.05）。两组患者麻醉过程中MAP、心率比较亦无明显差异，无统计学意义（P＞0.05）。两组患者麻醉过程中丙泊酚平均用量比较，A组明显低于C组，差异有统计学意义（P＜0.05），且不良反应发生率低。 结论 腺苷能明显降低全凭静脉麻醉中丙泊酚的使用剂量。
Objective To review the progress of in vivo study on degradable magnesium alloys application as bone-implant materials. Methods Recent literature was extensively reviewed and summarized, concerning the in vivo study on degradable magnesium alloys as orthopaedic implants. Results Magnesium alloys possess a natural ability to degrade via corrosion in vivo, which is promising candidate material for orthopaedic medical device applications. A great progress has been made to improve in vivo performance and integration with bone tissue. However, the degradation mechanism of magnesium-based materials in the physiological environment and long-term effect on body are not available. The modulation of the corrosion rate of magnesium alloys must also be accomplished. Conclusion Magnesium alloys have the potential to serve as degradable implants for orthopaedic applications, but a great deal of further investigation is still necessary.
Objective To review the progress of a disintegrin and metalloproteinase with thrombospondin motif 4 (ADAMTS-4) and ADAMTS-5 in osteoarthritis. Methods Recent literature about the ADAMTS-4 and -5 in osteoarthritis was analyzed; the structure, function, inhibitors of the ADAMTS-4 and -5, and the relationship between the proteases and osteoarthritis were analyzed and summarized. Results ADAMTS-4 and -5 can reduce chondrocyte and extracellular matrix by degrading aggrecan and cartilage oligomeric matrix protein, which induced the pathogenesis of osteoarthritis. Conclusion ADAMTS-4 and -5 have been demonstrated to play important roles in osteoarthritis. It can better guide treatment and prevention of osteoarthritis to further study related mechanism of ADAMTS-4 and -5, and to promote the establishment of a clinical drug targets.
【Abstract】 Objective To introduce the cl inical appl ication of heterogeneity (cattle) acellular dermal matrix(ADM)in the repair of mucosa defect otolaryngology. Methods From October 2006 to March 2007, 12 cases of mucosa defect was repaired with heterogeneity ADM after the surgery. There were 10 males and 2 females, aged 18-76 years. Defect was caused by deflection of nasal septum in 1 case, melanoma of front and midst basal is (capillary hemangioma) in 1 case, nasal vestibule angioma (T2N2M0)in 1 case, cancer of hypopharynx (T2N1M0) in 1 case, cancer of amygdale in 3 cases (2 of T2N0M0 and 1 of T3N1M0),cervical segments esophageal carcinoma in 1 case, and cancer of larynx in 4 cases (3 of T2N0M0 and 1 of T3N1M0). Results All these 12 cases were followed up for 6 months. The results of endoscope showed that heterogeneity ADM mingled with mucosa within 3 months after operation and the function was recovered. Pharynx fistula occurred in 1 case of hypopharynx cancer afterthe operation. After treatment of dressing change and antibiotics for 10 days, the wound healed, but after 2 months tumor recurred. All the patients were treated by radiation treatment. One case of amygdala cancer recurred and transferred to the neck after 2 months of radiation treatment. But 1 case of hypopharynx cancer died of massive haemorrhage after radiation treatment for 3 months. Conclusion Heterogeneity ADM can be easily obtained and it is a new method to repair mucosa defect. Theoperative procedure is easy to perform and worthwhile to be appl ied to cl inical operation.