High-quality development has become the command stick for the current reform of medical institutions. This article combines the practical experience of West China Hospital of Sichuan University to sort out the difficulties in the construction of provincial medical quality control centers in China. It summarizes the problems in policy support, intervention methods, work content, network construction, discipline construction, and quality control efficiency of provincial medical quality control centers, and proposes that building a collaborative platform based on key management projects, establishing a multi-level operation mode, and constructing a benchmark construction model are the key paths to reform the management of provincial medical quality control centers.