Recently, the increasing risk of drug development has impelled pharmaceutical enterprises to improve ways of research and exploitation. Adaptive design has been proposed for decades. Although the theory of this design is not perfect, it has been recognized and applied worldwide as a decreasing risk of drug development to a certain extent. The traditional fixed design in western medicine isn’t entirely suitable for traditional Chinese medicine (TCM), while the adaptive design with integrity and variability features provides a new idea for TCM development. Hereby the application of adaptive design in TCM is regarded as an important procedure for promoting TCM modernization, and it has a wide prospective.
Citation： ZHAI Jingbo,SHANG Hongcai. Status Quo of Adaptive Design in Drug Development Trials and Its Prospective in Traditional Chinese Medicine Research. Chinese Journal of Evidence-Based Medicine, 2012, 12(10): 1165-1170. doi: 10.7507/1672-2531.20120182 Copy