Objective To detect the false-positive results of cumulative meta-analyses of Cochrane Urology Group with the trial sequential analysis (TSA). Methods The systematic reviews of Urology Group of The Cochrane Library were searched to collect meta-analyses with positive results. Two researchers independently screened literature and extracted data of included meta-analyses. Then, TSA was performed using TSA software version 0.9 beta. Results A total of 11 meta-analyses were included. The results of TSA showed that, 8 of 11 (72.7%) meta-analyses were potentially false-positive results for failing to surpass the trial sequential monitoring boundary and to reach the required information size. Conclusion TSA can help researchers to identify the false-positive results of meta-analyses.
WENG Hong, WANG Chaoyang, HE Dalin, LI Sheng, PENG Shuanghe, ZENG Xiantao. Examining the false-positive results of meta-analysis of Cochrane urology group using trial sequential analysis. Chinese Journal of Evidence-Based Medicine, 2017, 17(4): 458-462. doi: 10.7507/1672-2531.201607064