Core outcome set (COS) is an agreed and minimal set of outcomes that should be measured and reported in all clinical trials in specific areas of health or healthcare, which can reduce the heterogeneity of outcomes in similar clinical trials, so that much more trials can merge in systematic reviews. Meanwhile, using COS may be easy to identify potential selective reporting bias in clinical trials. The research of COS has been developed for more than 30 years in western countries. At present there are much more researchers focusing on this area in China. However the status and progress of COS remain unclear. This paper reviewed the quantity of COS, the disease distributions of COS, the geographical locations involved in the development of COS, as well as the methodological progress of COS, so as to clarify the general situation of COS.
Citation： QIU Ruijin, CHEN Shiqi, HAN Songjie, HE Tianmai, HUANG Ya, LI Min, HU Jiayuan, SUN Yang, CHEN Jing, SHANG Hongcai. The research status and progress of core outcome sets based on COMET database. Chinese Journal of Evidence-Based Medicine, 2019, 19(5): 622-630. doi: 10.7507/1672-2531.201804022 Copy