Randomized controlled trials (RCTs) are the gold standard for the design of clinical trials. Because of some practical difficulties, more and more researchers think that the appropriate use of non-randomized controlled trials may make up for the weakness of RCT and will achieve the same research purpose. Therefore, non-RCTs are also very important. Taking studies on multiple sclerosis for example, this article briefly introduces the significance of non-randomized contolled trials.
Citation： WU Hongtao,ZHOU Dong,HE Li. Importance of Non-Randomized Controlled Trials. Chinese Journal of Evidence-Based Medicine, 2004, 04(8): 570-572. doi: Copy