Diagnostic Value of Serum Thyroglobulin, Diagnostic <sup>131</sup>I Whole-body Scan and Neck Ultrasonography for Evaluation of Lymph Node Metastasis and Recurrence of Differentiated Thyroid Cancer_West China Medical Journal

Authors：

 NIJian ^1,2 , WUXia ¹ , PANMing-zhi ¹ , HUANGRui ¹ ,  TANGGong-shun ¹

1. Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Nuclear Medicine, People's Hospital of Jianyang, Jiangyang, Sichuan 641400, P. R. China;

Corresponding author：

TANGGong-shun, Email: tgs010@163.com

Keywords：

Thyroid cancer; Thyroglobulin; Diagnostic ¹³¹I whole body scan

DOI：

10.7507/1002-0179.20140010

Video：

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Objective To compare the diagnostic efficacy of serum thyroglobulin (Tg), diagnostic ¹³¹I whole-body scan (D-WBS), neck ultrasound for diagnosing metastasis and recurrence of differentiated thyroid carcinoma (DTC). Methods From May to June 2011, fifty follow-up DTC patients were collected retrospectively 6 months or more after ¹³¹I ablation therapy following total-thyroidectomy or near-total thyroidectomy. The diagnostic standard for DTC metastasis and relapse were based on serum Tg, D-WBS, neck ultrasound and chest CT. Diagnostic 2 by 2 table was employed for calculating the sensitivity, specificity, accuracy of the methods. Results The sensitivity, specificity, accuracy, positive predictive value, negative predictive value of Tg_IMA and D-WBS parallel experiments were 100.0%, 92.9%, 96.0%, 91.7%, and 100.0% respectively. Conclusion Tg_IMA combined with D-WBS parallel test in diagnosis of DTC metastasis and recurrence has the highest accuracy.

Citation： NIJian, WUXia, PANMing-zhi, HUANGRui, TANGGong-shun. Diagnostic Value of Serum Thyroglobulin, Diagnostic ¹³¹I Whole-body Scan and Neck Ultrasonography for Evaluation of Lymph Node Metastasis and Recurrence of Differentiated Thyroid Cancer. West China Medical Journal, 2014, 29(1): 34-38. doi: 10.7507/1002-0179.20140010 Copy

1.	Agate L, Lorusso L, Elisei R. New and old knowledge on differentiated thyroid cancer epidemiology and risk factors[J]. J Endocrinol Invest, 2012, 35(6 Suppl):3-9.
2.	Spencer CA, Bergoglio LM, Kazarosyan M, et al. Clinical impact of thyroglobulin (Tg) and Tg autoantibody method differences on the management of patients with differentiated thyroid carcinomas[J]. J Clin Endocrinol Metab, 2005, 90(10):5566-5575.
3.	Chao M. Management of differentiated thyroid cancer with rising thyroglobulin and negative diagnostic radioiodine whole body scan[J]. Clin Oncol (R Coll Radiol), 2010, 22(6):438-447.
4.	田蓉, 潘明志, 匡安仁. Tg升高~(131)I显像阴性的甲状腺癌患者~(131)I疗效评价[J]. 中华核医学杂志, 2003, 23(1):25-27.
5.	马超, 匡安仁. 分化型甲状腺癌随访中~(131)I全身显像阴性但Tg阳性的原因及对策[J]. 中华核医学杂志, 2004, 24(1):53-55.
6.	袁耿彪, 匡安仁, 黄蕤, 等. 分化型甲状腺癌术后随访中停用左旋甲状腺素2周的临床价值[J]. 中华核医学杂志, 2006, 26(3):152-155.
7.	崔静, 刘保平, 高永举, 等. ¹³¹I显像及Tg值监测¹³¹I治疗分化型甲状腺癌肺转移灶疗效的探讨[J]. 中华核医学杂志, 2012, 32(6):422-425.
8.	Spencer CA. Clinical review:clinical utility of thyroglobulin antibody (TgAb) measurements for patients with differentiated thyroid cancers (DTC)[J]. J Clin Endocrinol Metab, 2011, 96(12):3615-3627.
9.	de Meer SG, Vriens MR, Zelissen PM, et al. The role of routine diagnostic radioiodine whole-body scintigraphy in patients with high-risk differentiated thyroid cancer[J]. J Nucl Med, 2011, 52(1):56-59.
10.	Zucchelli G, Iervasi A, Ferdeghini M, et al. Serum thyroglobulin measurement in the follow-up of patients treated for differentiated thyroid cancer[J]. Q J Nucl Med Mol Imaging, 2009, 53(5):482-489.
11.	Taylor H, Hyer S, Vini L, et al. Diagnostic ¹³¹I whole body scanning after thyroidectomy and ablation for differentiated thyroid cancer[J]. Eur J Endocrinol, 2004, 150(5):649-653.
12.	Küçük ON, Gültekin SS, Aras G, et al. Radioiodine whole-body scans, thyroglobulin levels, 99mTc-MIBI scans and computed tomography:results in patients with lung metastases from differentiated thyroid cancer[J]. Nucl Med Commun, 2006, 27(3):261-266.
13.	Middendorp M, Selkinski I, Happel C, et al. Comparison of positron emission tomography with[(18)F]FDG and[(68)Ga]DOTATOC in recurrent differentiated thyroid cancer:preliminary data[J]. Q J Nucl Med Mol Imaging, 2010, 54(1):76-83.
14.	Geerlings JA, van Zuijlen A, Lohmann EM, et al. The value of I-131 SPECT in the detection of recurrent differentiated thyroid cancer[J]. Nucl Med Commun, 2010, 31(5):417-422.
15.	陈贵平, 朱红兵, 冯郑娟, 等. 超声在甲状腺癌颈部淋巴结转移的诊断价值探讨[J]. 华西医学, 2009, 24(6):1433-1435.

1. Agate L, Lorusso L, Elisei R. New and old knowledge on differentiated thyroid cancer epidemiology and risk factors[J]. J Endocrinol Invest, 2012, 35(6 Suppl):3-9.
2. Spencer CA, Bergoglio LM, Kazarosyan M, et al. Clinical impact of thyroglobulin (Tg) and Tg autoantibody method differences on the management of patients with differentiated thyroid carcinomas[J]. J Clin Endocrinol Metab, 2005, 90(10):5566-5575.
3. Chao M. Management of differentiated thyroid cancer with rising thyroglobulin and negative diagnostic radioiodine whole body scan[J]. Clin Oncol (R Coll Radiol), 2010, 22(6):438-447.
4. 田蓉, 潘明志, 匡安仁. Tg升高~(131)I显像阴性的甲状腺癌患者~(131)I疗效评价[J]. 中华核医学杂志, 2003, 23(1):25-27.
5. 马超, 匡安仁. 分化型甲状腺癌随访中~(131)I全身显像阴性但Tg阳性的原因及对策[J]. 中华核医学杂志, 2004, 24(1):53-55.
6. 袁耿彪, 匡安仁, 黄蕤, 等. 分化型甲状腺癌术后随访中停用左旋甲状腺素2周的临床价值[J]. 中华核医学杂志, 2006, 26(3):152-155.
7. 崔静, 刘保平, 高永举, 等. ¹³¹I显像及Tg值监测¹³¹I治疗分化型甲状腺癌肺转移灶疗效的探讨[J]. 中华核医学杂志, 2012, 32(6):422-425.
8. Spencer CA. Clinical review:clinical utility of thyroglobulin antibody (TgAb) measurements for patients with differentiated thyroid cancers (DTC)[J]. J Clin Endocrinol Metab, 2011, 96(12):3615-3627.
9. de Meer SG, Vriens MR, Zelissen PM, et al. The role of routine diagnostic radioiodine whole-body scintigraphy in patients with high-risk differentiated thyroid cancer[J]. J Nucl Med, 2011, 52(1):56-59.
10. Zucchelli G, Iervasi A, Ferdeghini M, et al. Serum thyroglobulin measurement in the follow-up of patients treated for differentiated thyroid cancer[J]. Q J Nucl Med Mol Imaging, 2009, 53(5):482-489.
11. Taylor H, Hyer S, Vini L, et al. Diagnostic ¹³¹I whole body scanning after thyroidectomy and ablation for differentiated thyroid cancer[J]. Eur J Endocrinol, 2004, 150(5):649-653.
12. Küçük ON, Gültekin SS, Aras G, et al. Radioiodine whole-body scans, thyroglobulin levels, 99mTc-MIBI scans and computed tomography:results in patients with lung metastases from differentiated thyroid cancer[J]. Nucl Med Commun, 2006, 27(3):261-266.
13. Middendorp M, Selkinski I, Happel C, et al. Comparison of positron emission tomography with[(18)F]FDG and[(68)Ga]DOTATOC in recurrent differentiated thyroid cancer:preliminary data[J]. Q J Nucl Med Mol Imaging, 2010, 54(1):76-83.
14. Geerlings JA, van Zuijlen A, Lohmann EM, et al. The value of I-131 SPECT in the detection of recurrent differentiated thyroid cancer[J]. Nucl Med Commun, 2010, 31(5):417-422.
15. 陈贵平, 朱红兵, 冯郑娟, 等. 超声在甲状腺癌颈部淋巴结转移的诊断价值探讨[J]. 华西医学, 2009, 24(6):1433-1435.

West China Medical Journal

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Diagnostic Value of Serum Thyroglobulin, Diagnostic 131I Whole-body Scan and Neck Ultrasonography for Evaluation of Lymph Node Metastasis and Recurrence of Differentiated Thyroid Cancer

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Diagnostic Value of Serum Thyroglobulin, Diagnostic ¹³¹I Whole-body Scan and Neck Ultrasonography for Evaluation of Lymph Node Metastasis and Recurrence of Differentiated Thyroid Cancer