Observation on the Effect of Glucosamine Hydrochloride Combined with Antiosteoporosis Drugs in the Treatment of Senile Knee Osteoarthritis_West China Medical Journal

Authors：

 WangXinchun

Department of Pain, the First People’s Hospital of Neijiang, Neijiang, Sichuan 641000, P. R. China;

Corresponding author：

Keywords：

Osteoarthritis, knee; Osteoporosis; Glucosamine hydrochloride

DOI：

10.7507/1002-0179.201600229

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Objective To observe the clinical effect of combined glucosamine hydrochloride and antiosteoporosis drugs in the treatment of senile knee osteoarthritis. Methods A total of 120 patients with osteoarthritis of the knee treated from January 2014 to December 2015 were randomly divided into observation group and control group with 60 cases in each. The observation group received not only oral glucosamine hydrochloride, but calcium D3, alfacalcidol, and sodium phosphate for anti-osteoporosis treatment, while the control group was only given oral glucosamine hydrochloride. Lequesne score, curative effect and adverse drug reactions were compared between the two groups 2, 4, and 6 weeks after the beginning of treatment. Results Within two weeks of treatment, there was no significant difference between the two groups in the effective rate (P ＞ 0.05) . But four and six weeks after treatment, the efficiency in the observation group was significantly higher than that in the control group (χ²=6.806, P ＜ 0.01; χ²=24.762, P ＜ 0.01) . Four and six weeks after treatment, Lequesne score of the observation group was significantly lower than that of the control group (t=2.199, P ＜ 0.05; t=4.748, P ＜ 0.001) . There was no significant difference in terms of adverse reactions between the two groups before and after treatment (χ²=0.617, P ＞ 0.05) . Conclusion Compared with single hydrochloric amino glucose treatment, glucosamine hydrochloride combined with anti-osteoporosis treatment for senile knee osteoarthritis has better treatment effect without increase in adverse drug reactions, and it is worth of clinical application.

Citation： WangXinchun. Observation on the Effect of Glucosamine Hydrochloride Combined with Antiosteoporosis Drugs in the Treatment of Senile Knee Osteoarthritis. West China Medical Journal, 2016, 31(5): 838-840. doi: 10.7507/1002-0179.201600229 Copy

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9.	Gonzalez EB. ACP journal club. Review: glucosamine (sulfate or hydrochloride) does not reduce pain in knee or hip osteoarthritis[J]. Ann Intern Med, 2013, 159(12) : JC8.
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11.	朱秀英, 刘歆, 裴丽春, 等. 中老年妇女203例原发性骨质疏松症与骨关节病患病情况分析[J]. 中国临床康复, 2005, 9(39) : 136-137.
12.	吴波, 田卫群. 抗骨质疏松治疗对治疗膝骨性关节炎临床疗效的影响[J]. 中国中医骨伤科杂志, 2013, 21(7) : 27-29.
13.	Cosman F, De Beur SJ, Leboff MS, et al. Clinician’s guide to prevention and treatment of osteoporosis[J]. Osteoporos Int, 2014, 25(10) : 2359-2381.
14.	马厚勋. 老年骨质疏松症治疗策略[J]. 中华临床医师杂志: 电子版, 2013, 7(2) : 489-493.
15.	曾凯斌, 雷光华, 李康华. 骨质疏松症与骨关节炎的相关性研究进展[J]. 中国骨质疏松杂志, 2007, 13(1) : 63-68.
16.	张弛, 叶斌, 张海林, 等. 抗骨质疏松治疗对老年性膝关节骨关节炎疗效的影响[J]. 实用老年医学, 2011, 25(4) : 346-347.
17.	Mansfield K, Teixeira CC, Adams CS, et al. Phosphate ions mediate chondrocyte apoptosis through a plasma membrane transporter mechanism[J]. Bone, 2001, 28(1) : 1-8.

1. Lingard EA, Mitchell SY, Francis RM, et al. The prevalence of osteoporosis in patients with severe hip and knee osteoarthritis awaiting joint arthroplasty[J]. Age Ageing, 2010, 39(2) : 234-239.
2. 陈鸿儒. 玻璃酸钠注射液治疗膝关节骨关节炎疗效观察[J]. 现代中西医结合杂志, 2011, 20(4) : 449-450.
3. 曹小燕, 李凤霞, 叶青. 唑来膦酸钠抗骨质疏松治疗膝骨关节炎的疗效观察[J]. 湖北医药学院学报, 2014, 33(1) : 56-58.
4. Lequesne M. Indices of severity and disease activity for osteoarthritis[J]. Semin Arthritis Rheum, 1991, 20(6, Suppl 2) : 48-54.
5. 余素君, 纳世丽, 魏薇, 等. 盐酸氨基葡萄糖联合非甾体抗炎药治疗中度膝关节骨关节炎的临床研究[J]. 现代生物医学进展, 2015, 15(10) : 1919-1922.
6. 郭世绂. 性激素和细胞因子与骨关节炎及骨质疏松的关系[J]. 国外医学: 内分泌学分册, 2003, 23(2) : 98-100.
7. 施桂英. 关节炎概要[M]. 北京: 中国医药科技出版社, 2000: 432-433.
8. Kanzaki N, Saito K, Maeda A, et al. Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study[J]. J Sci Food Agric, 2012, 92(4) : 862-869.
9. Gonzalez EB. ACP journal club. Review: glucosamine (sulfate or hydrochloride) does not reduce pain in knee or hip osteoarthritis[J]. Ann Intern Med, 2013, 159(12) : JC8.
10. Hanssen AD, Stuart MJ, Scott RD, et al. Surgical options for the middle-aged patient with osteoarthritis of the knee joint[J]. Instr Course Lect, 2001, 50: 499-511.
11. 朱秀英, 刘歆, 裴丽春, 等. 中老年妇女203例原发性骨质疏松症与骨关节病患病情况分析[J]. 中国临床康复, 2005, 9(39) : 136-137.
12. 吴波, 田卫群. 抗骨质疏松治疗对治疗膝骨性关节炎临床疗效的影响[J]. 中国中医骨伤科杂志, 2013, 21(7) : 27-29.
13. Cosman F, De Beur SJ, Leboff MS, et al. Clinician’s guide to prevention and treatment of osteoporosis[J]. Osteoporos Int, 2014, 25(10) : 2359-2381.
14. 马厚勋. 老年骨质疏松症治疗策略[J]. 中华临床医师杂志: 电子版, 2013, 7(2) : 489-493.
15. 曾凯斌, 雷光华, 李康华. 骨质疏松症与骨关节炎的相关性研究进展[J]. 中国骨质疏松杂志, 2007, 13(1) : 63-68.
16. 张弛, 叶斌, 张海林, 等. 抗骨质疏松治疗对老年性膝关节骨关节炎疗效的影响[J]. 实用老年医学, 2011, 25(4) : 346-347.
17. Mansfield K, Teixeira CC, Adams CS, et al. Phosphate ions mediate chondrocyte apoptosis through a plasma membrane transporter mechanism[J]. Bone, 2001, 28(1) : 1-8.

West China Medical Journal

Observation on the Effect of Glucosamine Hydrochloride Combined with Antiosteoporosis Drugs in the Treatment of Senile Knee Osteoarthritis

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