Study on the Effect of Glucosamine Hydrochloride Combined with Risedronate in the Treatment of Knee Osteoarthritis Associated with Cold Pain of Knee_West China Medical Journal

Authors：

 LiMin ¹ ,  WuXiaohui ² , YiWeien ³ , LiangYi ¹ , TangLiugang ² , YuWenjing ¹ , ShaHu ¹ , WuJia ¹ , WangCuiping ¹

1. Department of Rheumatology and Osteoarthritis, Sichuan Orthopedic Hospital, Chengdu, Sichuan 610041,P. R. China;
2. Department of Sinew Injury, Sichuan Orthopedic Hospital, Chengdu, Sichuan 610041,P. R. China;
3. Department of Rehabilitation, TCM Hospital of Yuechi County, Guang’an, Sichuan 638300, P. R. China;

Corresponding author：

WuXiaohui, Email: noll777@qq.com

Keywords：

Osteoarthritis, knee; Cold pain of knee; Glucosamine hydrochloride; Risedronate

DOI：

10.7507/1002-0179.201600230

Video：

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Objective To evaluate the efficacy of the glucosamine hydrochloride combined with risedronate in the treatment of knee osteoarthritis (KOA) associated with cold pain of knee. Methods The clinical data of 50 KOA patients including 25 with cold pain and 25 without cold pain, treated in the Department of Rheumatology between January and December 2015 were collected. The clinical symptoms, Western Ontario and McMater Universities (WOMAC) index of osteoarthritis score, knee cold pain score, knee joint therml texture maps (TTM) score, serum osteoprotegerin (OPG), Dickkopf-1 (DKK-1) , and sclerostin levels (SO) were recorded for comparison between patients with and without cold pain in order to investigate the correlation between these indicators and cold pain degree. Patients in the cold pain group were treated with glucosamine hydrochloride combined with risedronate. Follow-up lasted for six months, and the improvement of above indexes and the treatment safety were analyzed. Results There were significant differences between the two groups in the disease course, TTM score of knee front and popliteal fossa, ΔTTM, DKK-1 and SO (P ＜ 0.05) . After 6 months of treatment, patients in the cold pain group improved significantly in WOMAC score, knee cold pain score, TTM score of knee front and popliteal fossa, ΔTTM, OPG, DKK-1 and SO (P ＜ 0.05) . Conclusions As one of the main complaints of patients with advanced OA, knee cold pain is associated with the metabolic activity of osteoclasts. It can be alleviated by the treatment with risedronate combined with glucosamine.

Citation： LiMin, WuXiaohui, YiWeien, LiangYi, TangLiugang, YuWenjing, ShaHu, WuJia, WangCuiping. Study on the Effect of Glucosamine Hydrochloride Combined with Risedronate in the Treatment of Knee Osteoarthritis Associated with Cold Pain of Knee. West China Medical Journal, 2016, 31(5): 841-844. doi: 10.7507/1002-0179.201600230 Copy

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2. 李敏, 伊伟恩, 吴晓惠, 等. 类风湿关节炎伴膝冷痛的相关因素分析[J]. 四川大学学报: 医学版, 2015, 46(2) : 293-295.
3. 樊秋贵, 郭钧, 杨民. OPG RANKL RANK等因子在类风湿关节炎患者血清及滑膜液中的变化及意义[J]. 中华风湿病学杂志, 2007, 11(1) : 38-40.
4. Uderhardt S, Diarra D, Katzenbeisser J, et al. Blockade of dickkopf (DKK)-1 induces fusion of sacroiliac joints[J]. Ann Rheum Dis, 2010, 69(3) : 592-597.
5. 赵凤仪, 王莉. 硬骨素在骨生成中的作用[J]. 中国骨质疏松杂志, 2009, 15(6) : 460-462, 472.
6. 黄胜光, 陈辉, 周汝云, 等. 蜂针疗法对风湿寒性关节痛患者中医证候评分及血液流变学的影响[J]. 中医药导报, 2012, 9(9) : 16-18.
7. 李敏, 梁翼, 余文景, 等. 盐酸氨基葡萄糖联合双醋瑞因在伴骨髓水肿的膝骨关节炎的疗效评估[J]. 华西医学, 2012, 12(12) : 1764- 1767.
8. 刘湘源, 赵金霞, 姚中强, 等. 图表式临床风湿病学[M]. 北京: 中国医药科技出版社, 2013: 468-470.
9. 刘孟宇, 李勇, 韩庆森. 膝骨关节炎与风湿寒性关节痛的TTM鉴别诊断[J]. 中国中西医结合影像学杂志, 2008, 6(2) : 111-113.
10. Rachner TD, Göbel A, Benad-Mehner P, et al. Dickkopf-1 as a mediator and novel target in malignant bone disease[J]. Cancer Lett, 2014, 346(2) : 172-177.
11. 陈枝琼, 李向培, 厉小梅, 等. 强直性脊柱炎患者外周血中 Dickkopf-1和硬骨素的表达及临床意义[J]. 安徽医科大学学报, 2013, 48(6) : 671-674.
12. Pazianas M, Cooper C, Ebetino FH, et al. Long-term treatment with bisphosphonates and their safety in postmenopausal osteoporosis[J]. Ther Clin Risk Manag, 2010, 6(1) : 325-343.
13. 曲新华, 郝永强. 双膦酸盐在骨科相关疾病治疗中的地位及再认识[J]. 中华骨科杂志, 2014, 34(1) : 78-80.
14. 吴晓惠, 赵琛, 钟义兰, 等. 盐酸氨基葡萄糖联合抗骨增生片治疗不同类型膝骨关节炎疗效比较[J]. 华西医学, 2012, 12(12) : 1792- 1795.
15. 戴燚, 杨欢, 张汉庆, 等. 盐酸氨基葡萄糖联合降钙素对绝经后膝骨关节炎基质金属蛋白酶3和骨桥蛋白表达的影响[J]. 华西医学, 2012, 12(12) : 1772-1775.

West China Medical Journal

Study on the Effect of Glucosamine Hydrochloride Combined with Risedronate in the Treatment of Knee Osteoarthritis Associated with Cold Pain of Knee

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