Current status and trends in research on chemotherapy-induced premature ovarian failure from a bibliometric perspective_West China Medical Journal

Authors：

WANG Yuhang ¹ , HU Xuemin ² ,  DU Xue ²

1. Graduate School, Tianjin Medical University, Tianjin 300070, P. R. China;
2. Department of Gynecology, Tianjin Union Medical Center, Nankai University, Tianjin 300121, P. R. China;

Corresponding author：

DU Xue, Email: lanlandetommao@163.com

Keywords：

Bibliometrics; chemotherapy-induced premature ovarian failure; visualization mapping

DOI：

10.7507/1002-0179.202407022

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To analyze the research progress and current situation in the field of chemotherapy-induced premature ovarian failure by bibliometrics, so as to provide scientific and efficient research path for researchers. Methods All the literature on chemotherapy-induced premature ovarian failure from 2015 to 2024 was retrieved from the Web of Science Core Collection. CiteSpace and VOSviewer software were used to conduct bibliometric analyses of authors, institutions, keywords, co-cited documents, etc., and to draw the relational graphs. Results A total of 567 papers were included. The annual research output increased slightly, and the number of papers published by Chinese researchers ranked first. The 49 selected keywords were divided into 11 clusters, and the emerging keywords showed that the research hotspots in recent years focused on more in-depth mechanism studies, such as primary ovarian insufficiency and fertility preservation in premenopausal patients, which might continue to be research hotspots. Conclusions In recent years, the research heat of chemotherapy-induced premature ovarian failure has been increasing, and Chinese scholars have made outstanding contributions, however, it is necessary to further strengthen the scientific research cooperation among researchers. Fertility preservation, hormone replacement therapy, in vitro transplantation may become the hotspots of future research, and the depth and refinement of research should be further promoted on the basis of multi-center and multi-disciplinary cross.

Citation： WANG Yuhang, HU Xuemin, DU Xue. Current status and trends in research on chemotherapy-induced premature ovarian failure from a bibliometric perspective. West China Medical Journal, 2025, 40(3): 439-446. doi: 10.7507/1002-0179.202407022 Copy

1.	Goswami D, Conway GS. Premature ovarian failure. Hum Reprod Update, 2005, 11(4): 391-410.
2.	Chen L, Guo S, Wei C. Effect of stem cell transplantation of premature ovarian failure in animal models and patients: a meta-analysis and case report. Exp Ther Med, 2018, 15(5): 4105-4118.
3.	Chen H, Liu C, Zhu S, et al. The therapeutic effect of stem cells on chemotherapy-induced premature ovarian failure. Curr Mol Med, 2021, 21(5): 376-384.
4.	Merigó JM, Gil-Lafuente AM, Yager RR. An overview of fuzzy research with bibliometric indicators. Appl Soft Comput, 2015, 27: 420-433.
5.	Mayr P, Scharnhorst A. Scientometrics and information retrieval: weak-links revitalized. Scientometrics, 2014, 102(3): 2193-2199.
6.	Chen C. Citespace II: detecting and visualizing emerging trends and transient patterns in scientific literature. J AM Soc Inf Sci Technol, 2006(3): 359-377.
7.	van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics, 2010, 84(2): 523-538.
8.	钟文娟. 基于普赖斯定律与综合指数法的核心作者测评——以《图书馆建设》为例. 科技管理研究, 2012, 32(2): 57-60.
9.	陈悦, 陈超美, 刘则渊, 等. CiteSpace 知识图谱的方法论功能. 科学学研究, 2015, 33(2): 242-253.
10.	Zhang C, Xu X. Advancement in the treatment of diminished ovarian reserve by traditional Chinese and Western medicine. Exp Ther Med, 2016, 11(4): 1173-1176.
11.	Qiao J, Feng HL. Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence. Hum Reprod Update, 2011, 17(1): 17-33.
12.	Moore HC, Unger JM, Phillips KA, et al. Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy. N Engl J Med, 2015, 372(10): 923-932.
13.	Cho HW, Lee S, Min KJ, et al. Advances in the treatment and prevention of chemotherapy-induced ovarian toxicity. Int J Mol Sci, 2020, 21(20): 7792.
14.	Guo Y, Xue L, Tang W, et al. Ovarian microenvironment: challenges and opportunities in protecting against chemotherapy-associated ovarian damage. Hum Reprod Update, 2024, 30(5): 614-647.
15.	Gu M, Wang Y, Yu Y. Ovarian fibrosis: molecular mechanisms and potential therapeutic targets. J Ovarian Res, 2024, 17(1): 139.
16.	Dai F, Wang R, Deng Z, et al. Comparison of the different animal modeling and therapy methods of premature ovarian failure in animal model. Stem Cell Res Ther, 2023, 14(1): 135.
17.	谢鹏昊, 张超, 文涛, 等. 基于 Web of Science 文献计量分析的青枯病研究进展. 中国农业大学学报, 2020, 25(11): 62-73.
18.	Chen CM. Searching for intellectual turning points: progressive knowledge domain visualization. Proc Natl Acad Sci U S A, 2004, 101(Suppl 1): 5303-5310.
19.	Eichler E, Richards S, Gibbs RA, et al. Fine structure of the human FMR1 gene. Hum Mol Genet, 1993, 2(8): 1147-1153.
20.	Ding DC, Shyu WC, Lin SZ. Mesenchymal stem cells. Cell Transplant, 2011, 20(1): 5-14.

1. Goswami D, Conway GS. Premature ovarian failure. Hum Reprod Update, 2005, 11(4): 391-410.
2. Chen L, Guo S, Wei C. Effect of stem cell transplantation of premature ovarian failure in animal models and patients: a meta-analysis and case report. Exp Ther Med, 2018, 15(5): 4105-4118.
3. Chen H, Liu C, Zhu S, et al. The therapeutic effect of stem cells on chemotherapy-induced premature ovarian failure. Curr Mol Med, 2021, 21(5): 376-384.
4. Merigó JM, Gil-Lafuente AM, Yager RR. An overview of fuzzy research with bibliometric indicators. Appl Soft Comput, 2015, 27: 420-433.
5. Mayr P, Scharnhorst A. Scientometrics and information retrieval: weak-links revitalized. Scientometrics, 2014, 102(3): 2193-2199.
6. Chen C. Citespace II: detecting and visualizing emerging trends and transient patterns in scientific literature. J AM Soc Inf Sci Technol, 2006(3): 359-377.
7. van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics, 2010, 84(2): 523-538.
8. 钟文娟. 基于普赖斯定律与综合指数法的核心作者测评——以《图书馆建设》为例. 科技管理研究, 2012, 32(2): 57-60.
9. 陈悦, 陈超美, 刘则渊, 等. CiteSpace 知识图谱的方法论功能. 科学学研究, 2015, 33(2): 242-253.
10. Zhang C, Xu X. Advancement in the treatment of diminished ovarian reserve by traditional Chinese and Western medicine. Exp Ther Med, 2016, 11(4): 1173-1176.
11. Qiao J, Feng HL. Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence. Hum Reprod Update, 2011, 17(1): 17-33.
12. Moore HC, Unger JM, Phillips KA, et al. Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy. N Engl J Med, 2015, 372(10): 923-932.
13. Cho HW, Lee S, Min KJ, et al. Advances in the treatment and prevention of chemotherapy-induced ovarian toxicity. Int J Mol Sci, 2020, 21(20): 7792.
14. Guo Y, Xue L, Tang W, et al. Ovarian microenvironment: challenges and opportunities in protecting against chemotherapy-associated ovarian damage. Hum Reprod Update, 2024, 30(5): 614-647.
15. Gu M, Wang Y, Yu Y. Ovarian fibrosis: molecular mechanisms and potential therapeutic targets. J Ovarian Res, 2024, 17(1): 139.
16. Dai F, Wang R, Deng Z, et al. Comparison of the different animal modeling and therapy methods of premature ovarian failure in animal model. Stem Cell Res Ther, 2023, 14(1): 135.
17. 谢鹏昊, 张超, 文涛, 等. 基于 Web of Science 文献计量分析的青枯病研究进展. 中国农业大学学报, 2020, 25(11): 62-73.
18. Chen CM. Searching for intellectual turning points: progressive knowledge domain visualization. Proc Natl Acad Sci U S A, 2004, 101(Suppl 1): 5303-5310.
19. Eichler E, Richards S, Gibbs RA, et al. Fine structure of the human FMR1 gene. Hum Mol Genet, 1993, 2(8): 1147-1153.
20. Ding DC, Shyu WC, Lin SZ. Mesenchymal stem cells. Cell Transplant, 2011, 20(1): 5-14.

West China Medical Journal

Current status and trends in research on chemotherapy-induced premature ovarian failure from a bibliometric perspective

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