Mechanism of blood brain barrier in the pathogenesis of epilepsy_West China Medical Journal

Authors：

WANG Baoxiang ¹ , ZHANG Xiutian ² ,  CHAI Changfeng ²

1. Department of Neurology, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, P. R. China;
2. Department of Neurology, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, P. R. China;

Corresponding author：

CHAI Changfeng, Email: chaicf0206@126.com

Keywords：

Blood brain barrier; epilepsy; pathogenesis; treatment

DOI：

10.7507/1002-0179.202408289

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Epilepsy is one of the common chronic diseases in neurology, and antiepileptic medication is the main treatment method. Studies have shown that epileptic seizures may disrupt the permeability of the blood brain barrier (BBB), and BBB disruption may also lead to epilepsy. This article reviews the mechanism of BBB in the pathogenesis of epilepsy based on relevant research progress, elucidates the relationship between BBB and epilepsy, and proposes possible directions for future research and development of antiepileptic drugs.

Citation： WANG Baoxiang, ZHANG Xiutian, CHAI Changfeng. Mechanism of blood brain barrier in the pathogenesis of epilepsy. West China Medical Journal, 2025, 40(5): 817-820. doi: 10.7507/1002-0179.202408289 Copy

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1.
2. van Vliet EA, da Costa Araújo S, Redeker S, et al. Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy. Brain, 2007, 130(Pt 2): 521-534.
3.
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5. Rigau V, Morin M, Rousset MC, et al. Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy. Brain, 2007, 130(Pt 7): 1942-1956.
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West China Medical Journal

Mechanism of blood brain barrier in the pathogenesis of epilepsy

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