• Department of Thoracic Surgery, Wuhan University People’s Hospital, Wuhan, 430060, P. R. China;
GENG Qing, Email: gengqingwhu@whu.edu.cn
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Non-small cell lung cancer is one of the primary types of cancer that leads to brain metastases. Approximately 10% of patients with non-small cell lung cancer have brain metastases at the time of diagnosis, and 26%-53% of patients develop brain metastases during the progression of their disease. However, the underlying mechanisms of lung cancer brain metastasis have not been fully elucidated. With the continuous development of single-cell and spatial transcriptomics, the genomic and transcriptomic characteristics of lung cancer brain metastasis are gradually being revealed. In February 2025, the journal Nature Medicine published an article titled "Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases". This article aims to provide a brief interpretation of the paper for colleagues in research and clinical practice.

Citation: ZOU Shishi, HE Ruyuan, LUO Guoqing, LI Ning, GENG Qing. Interpretation of "Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases". Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2025, 32(7): 953-957. doi: 10.7507/1007-4848.202504006 Copy

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