Correlation between Polymorphism in Exon-4 of PC-1 Gene and Type 2 Diabetes Mellitus in Chinese Population: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

CHEN Xiaowen ,  LI Ling , YANG Shengjie

Cadre Endocrine Department, The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine, Hefei 230061, China;

Corresponding author：

LI Ling, Email: 640347226@qq.com

Keywords：

PC-1; Polymorphism; Type 2 Diabetes Mellitus; Chinese population; Systematic review; Meta-analysis; Case-control study

DOI：

10.7507/1672-2531.20130053

Video：

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Objective 　To systematically evaluate the correlation between type 2 diabetes mellitus (T2DM) in Chinese population and K121Q polymorphism in exon-4 of plasma cell glycoprotrin-1 (PC-1) gene.
Methods 　The following databases such as CNKI, VIP, CBM, PubMed, EMbase, The Cochrane Library (Issue 3, 2012) and WanFang Data were searched to collect case-control studies on the correlation between T2DM and K121Q polymorphism in exon-4 of PC-1 gene. The retrieval time was from 1980 to 2012. Two reviewers independently screened the literature according to the inclusion and exclusion criteria, extracted the data and assessed the quality. Then the meta-analysis was conducted by using RevMan 5.0 and Stata 12.0 software, and the publication bias was analyzed by means of Egger’s linear regression.
Results 　A total of 11 studies involving 1 637 T2DM patients and 1 730 healthy volunteers were included. The results of meta-analyses showed that, for Chinese population, the risk of T2DM was higher in those with K/Q genotype than K/K genotype (OR=1.84, 95%CI 1.19 to 2.85, P=0.006), in Q/Q+K/Q genotype than K/K genotype (OR=1.92, 95%CI 1.18 to 3.14, P=0.009), and also in allele Q than allele K (OR=1.83, 95%CI 1.16 to 2.89, P=0.010).
Conclusion 　The K121Q polymorphism in exon-4 of PC-1 gene in Chinese population is significantly associated with T2DM. For the quantity and quality limitation of the included studies, this conclusion has to be further proved by more studies.

Citation： CHEN Xiaowen,LI Ling,YANG Shengjie. Correlation between Polymorphism in Exon-4 of PC-1 Gene and Type 2 Diabetes Mellitus in Chinese Population: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2013, 13(3): 308-312. doi: 10.7507/1672-2531.20130053 Copy

1.	Gu HF, Almgren P, Lindholm E, et al. Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis. Diabetes, 2000, 49(9): 1601-1603.
2.	Rasmussen SK, Urhammer SA, Pizzuti A, et al. The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians. Diabetes, 2000, 49(9): 1608-1611.
3.	Little J, Higgins JP, Ioannidis JP, et al. Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement. Eur J Epidemiol, 2009, 24(1): 37-55.
4.	王静, 莫传伟, 陈群, 等. 应用Stata软件的Meta分析完成医学科研定量评价. 中华中医药学刊, 2008, 26(5): 947-949.
5.	徐梅, 王德全, 许玲, 等. 膜糖蛋白PC-1基因K121Q多态性与2型糖尿病相关性. 中华内分泌代谢杂志, 2003, 19(5): 390-391.
6.	任伟, 张素华, 吴静, 等. 2型糖尿病家系膜糖蛋白PC-1基因多态性的研究. 中华糖尿病杂志, 2004, 12(4): 246-249.
7.	于永春, 李智, 李晶华, 等. PC-1基因K121Q变异与2型糖尿病的关系. 检验医学, 2005, 20(4): 313-316.
8.	芦鹭, 高政南. PC-1基因K121Q多态性与2型糖尿病及肥胖相关性的研究. 大连医学大学硕士学位论文, 2006.
9.	钟严伟, 高玲, 吴少庭, 等. PC-1基因K121Q多态性与2型糖尿病相关性研究. 中国热带医学, 2006, 6(12): 2113-2114.
10.	刘茂玲, 吴少庭, 卢祖洵. PC-1基因多态性与2型糖尿病及胰岛素抵抗的相关性. 中国慢性病预防与控制, 2006, 2(14): 15-17.
11.	兰翠霞, 刘梦阳, 申黎燕. PC-1基因K121Q变异与2型糖尿病肾病的关系. 医学检验与临床, 2008, 19(4): 20-22.
12.	李梅蕊, 吴于滨, 刘华, 等. PC-1基因多态性与2型糖尿病及糖尿病肾病的相关性研究. 昆明医学院学报, 2008, 29(1): 27-31.
13.	史晓红, 杨泽, 孙亮, 等. 浆细胞膜糖蛋白基因K121Q变异与老年人2型糖尿病的关联研究. 中国老年保健医学杂志, 2008, 6(5): 3-6.
14.	高玲, 刘茂玲, 吴少庭, 等. 深圳地区人群2型糖尿病相关基因多态性的研究. 热带医学杂志, 2008, 8(6): 553-555.
15.	罗莉, 黄凌宁, 许昌声, 等. 浆细胞膜糖蛋白1基因多态性与2型糖尿病合并冠状动脉硬化性心脏病的关系. 中华高血压杂志, 2011, 19(1): 61-64.
16.	康德英, 王家良. Meta分析结果评价. 见：王家良, 主编. 循证医学, 第2版. 北京: 人民卫生出版社, 2011: 90-91.
17.	王丹, 牟振云, 翟俊霞, 等. Stata软件在Meta-分析发表性偏倚识别中的探讨. 现代预防医学, 2008, 35(15): 2819-2822.
18.	Maddux BA, Goldfine ID. Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit. Diabetes, 2000, 49(1): 13-19.
19.	骆惠均, 王铸钢. PC-1与胰岛素抵抗. 国外医学-生理、病理科学与临床分册, 2001, 21(6): 497-500.
20.	Costanzo BV, Trischitta V, Di Paola R, et al. The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121). Diabetes, 2001, 50(4): 831-836.
21.	Menzaghi C, Di Paola R, Baj G, et al. Insulin modulates PC-1 processing and recruitment in cultured human cells. Am J Physiol Endocrinol Metab, 2003, 284(3): 514-520.

1. Gu HF, Almgren P, Lindholm E, et al. Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis. Diabetes, 2000, 49(9): 1601-1603.
2. Rasmussen SK, Urhammer SA, Pizzuti A, et al. The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians. Diabetes, 2000, 49(9): 1608-1611.
3. Little J, Higgins JP, Ioannidis JP, et al. Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement. Eur J Epidemiol, 2009, 24(1): 37-55.
4. 王静, 莫传伟, 陈群, 等. 应用Stata软件的Meta分析完成医学科研定量评价. 中华中医药学刊, 2008, 26(5): 947-949.
5. 徐梅, 王德全, 许玲, 等. 膜糖蛋白PC-1基因K121Q多态性与2型糖尿病相关性. 中华内分泌代谢杂志, 2003, 19(5): 390-391.
6. 任伟, 张素华, 吴静, 等. 2型糖尿病家系膜糖蛋白PC-1基因多态性的研究. 中华糖尿病杂志, 2004, 12(4): 246-249.
7. 于永春, 李智, 李晶华, 等. PC-1基因K121Q变异与2型糖尿病的关系. 检验医学, 2005, 20(4): 313-316.
8. 芦鹭, 高政南. PC-1基因K121Q多态性与2型糖尿病及肥胖相关性的研究. 大连医学大学硕士学位论文, 2006.
9. 钟严伟, 高玲, 吴少庭, 等. PC-1基因K121Q多态性与2型糖尿病相关性研究. 中国热带医学, 2006, 6(12): 2113-2114.
10. 刘茂玲, 吴少庭, 卢祖洵. PC-1基因多态性与2型糖尿病及胰岛素抵抗的相关性. 中国慢性病预防与控制, 2006, 2(14): 15-17.
11. 兰翠霞, 刘梦阳, 申黎燕. PC-1基因K121Q变异与2型糖尿病肾病的关系. 医学检验与临床, 2008, 19(4): 20-22.
12. 李梅蕊, 吴于滨, 刘华, 等. PC-1基因多态性与2型糖尿病及糖尿病肾病的相关性研究. 昆明医学院学报, 2008, 29(1): 27-31.
13. 史晓红, 杨泽, 孙亮, 等. 浆细胞膜糖蛋白基因K121Q变异与老年人2型糖尿病的关联研究. 中国老年保健医学杂志, 2008, 6(5): 3-6.
14. 高玲, 刘茂玲, 吴少庭, 等. 深圳地区人群2型糖尿病相关基因多态性的研究. 热带医学杂志, 2008, 8(6): 553-555.
15. 罗莉, 黄凌宁, 许昌声, 等. 浆细胞膜糖蛋白1基因多态性与2型糖尿病合并冠状动脉硬化性心脏病的关系. 中华高血压杂志, 2011, 19(1): 61-64.
16. 康德英, 王家良. Meta分析结果评价. 见：王家良, 主编. 循证医学, 第2版. 北京: 人民卫生出版社, 2011: 90-91.
17. 王丹, 牟振云, 翟俊霞, 等. Stata软件在Meta-分析发表性偏倚识别中的探讨. 现代预防医学, 2008, 35(15): 2819-2822.
18. Maddux BA, Goldfine ID. Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit. Diabetes, 2000, 49(1): 13-19.
19. 骆惠均, 王铸钢. PC-1与胰岛素抵抗. 国外医学-生理、病理科学与临床分册, 2001, 21(6): 497-500.
20. Costanzo BV, Trischitta V, Di Paola R, et al. The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121). Diabetes, 2001, 50(4): 831-836.
21. Menzaghi C, Di Paola R, Baj G, et al. Insulin modulates PC-1 processing and recruitment in cultured human cells. Am J Physiol Endocrinol Metab, 2003, 284(3): 514-520.

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Correlation between Polymorphism in Exon-4 of PC-1 Gene and Type 2 Diabetes Mellitus in Chinese Population: A Meta-Analysis

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