Correlation between Coffee and Risk of Endometrial Cancer: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

HUANG Shijin ,  XU hong , WEI Wei

Gynecologic Department, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530000, China;

Corresponding author：

XU hong, Email: nnxuhong@163.com

Keywords：

Endometrial cancer; Coffee; Caffeine; Systematic review; Meta-analysis; Cohort study

DOI：

10.7507/1672-2531.20130054

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To systematically evaluate the correlation between coffee and risk of endometrial cancer.
Methods 　Such databases as CBM, CNKI, WanFang data, PubMed, EMbase and The Cochrane Library (Issue 5, 2012) were searched to collect the prospective cohort studies about correlation between coffee and endometrial cancer. The retrieval time was by the end of May 2012, and the references of the included literature were also retrieved. Two evaluators independently screened the literature according to the inclusion and exclusion criteria, extracted the data, and assessed the quality, and then the statistical analysis was conducted by using Stata 12.0 software.
Results 　A total of 10 cohort studies involving 4 484 patients with endometrial cancer were included. The results of meta-analysis showed that, compared with the women who didn’t drink coffee or drank in the lowest dose, the women who drank coffee in the highest dose had a decreased risk of endometrial cancer (RR=0.69, 95%CI 0.62 to 0.78), same as the women who drank coffee frequently (RR=0.83, 95%CI 0.77 to 0.89). The results of dose-response analysis revealed that, when there was an increase of 2 more cups of coffee per day, there was the risk of endometrial cancer decreased by 12%.
Conclusion 　Drinking coffee frequently (more than 2 cups per day) can decrease the risk of endometrial cancer which can be significantly decreased when drinking in a big dose (more than 5 cups per day).

Citation： HUANG Shijin,XU hong,WEI Wei. Correlation between Coffee and Risk of Endometrial Cancer: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2013, 13(3): 313-319. doi: 10.7507/1672-2531.20130054 Copy

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2.	Akhmedkhanov A, Zeleniuch-Jacquotte A, Toniolo P. Role of Exogenous and Endogenous Hormones in Endometrial Cancer. Annals of the New York Academy of Sciences, 2001, 943(1): 296-315.
3.	Yu X, Bao Z, Zou J, et al. Coffee consumption and risk of cancers: a meta-analysis of cohort studies. BMC Cancer, 2011, 11(1): 96.
4.	Kaaks R, Lukanova A, Kurzer MS. Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. Cancer Epidemiol Biomarkers Prev, 2002, 11(12): 1531-1543.
5.	Je Y, Giovannucci E. Coffee consumption and risk of endometrial cancer: Findings from a large up-to-date meta-analysis. Int J Cancer, 2012, 131(7): 1700-1710.
6.	Bravi F, Scotti L, Bosetti C, et al. Coffee drinking and endometrial cancer risk: a metaanalysis of observational studies. American Journal of Obstetrics and Gynecology, 2009, 200(2): 130-135.
7.	Wells G, Shea B, O’Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2010. Available from: URL: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
8.	Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA, 2000, 283(15): 2008-2012.
9.	Greenland S, Longnecker MP. Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. Am J Epidemiol, 1992, 135(11): 1301-1309.
10.	Orsini N, Bellocco R, Greenland S. Generalized least squares for trend estimation of summarized dose-response data. The Stata Journal, 2006, 6(1): 40-57.
11.	Friberg E, Orsini N, Mantzoros CS, et al. Coffee drinking and risk of endometrial cancer-A population-based cohort study. International Journal of Cancer, 2009, 125(10): 2413-2417.
12.	Je Y, Hankinson SE, Tworoger SS, et al. A Prospective Cohort Study of Coffee Consumption and Risk of Endometrial Cancer over a 26-Year Follow-Up. Cancer Epidemiology Biomarkers & Prevention, 2011, 20(12): 2487-2495.
13.	Stensvold I, Jacobsen BK. Coffee and cancer: a prospective study of 43,000 Norwegian men and women. Cancer Causes Control, 1994, 5(5): 401-408.
14.	Uccella S, Mariani A, Wang A, et al. Coffee consumption and the risk of endometrial cancer in postmenopausal women. Gynecol Oncol, 2010, 116(3): S75-S76.
15.	Jacobsen BK, Bjelke E, Kvale G, et al. Coffee drinking, mortality, and cancer incidence: results from a Norwegian prospective study. J Natl Cancer Inst, 1986, 76(5): 823-831.
16.	Gavrilyuk O, Braaten T, Skeie G, et al. Coffee consumption and endometrial cancer risk among postmenopausal women in the norwegian women and cancer (NOWAC) study. International Journal of Gynecological Cancer, 2011, 21(12 SUPPL. 3): S509.
17.	Shimazu T, Inoue M, Sasazuki S, et al. Coffee consumption and risk of endometrial cancer: A prospective study in Japan. International Journal of Cancer, 2008, 123(10): 2406-2410.
18.	Nilsson LM, Johansson I, Lenner P, et al. Consumption of filtered and boiled coffee and the risk of incident cancer: a prospective cohort study. Cancer Causes & Control, 2010, 21(10): 1533-1544.
19.	Giri A, Sturgeon SR, Luisi N, et al. Caffeinated Coffee, Decaffeinated Coffee and Endometrial Cancer Risk: A Prospective Cohort Study among US Postmenopausal Women. Nutrients, 2011, 3(11): 937-950.
20.	Gunter MJ, Schaub JA, Xue X, et al. A prospective investigation of coffee drinking and endometrial cancer incidence. International Journal of Cancer, 2012, 131(4): E530-E536.
21.	Goto A, Song Y, Chen BH, et al. Coffee and Caffeine Consumption in Relation to Sex Hormone-Binding Globulin and Risk of Type 2 Diabetes in Postmenopausal Women. Diabetes, 2010, 60(1): 269-275.
22.	van Dieren S, Uiterwaal CS, van der Schouw YT, et al. Coffee and tea consumption and risk of type 2 diabetes. Diabetologia, 2009, 52(12): 2561-2569.
23.	Cavin C, Holzhaeuser D, Scharf G, et al. Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity. Food and Chemical Toxicology, 2002, 40(8): 1155-1163.
24.	Butt MS, Sultan MT. Coffee and its consumption: benefits and risks. Crit Rev Food Sci Nutr, 2011, 51(4): 363-373.
25.	Khan N, Afaq F, Mukhtar H. Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxid Redox Signal, 2008, 10(3): 475-510.
26.	McCusker RR, Fuehrlein B, Goldberger BA, et al. Caffeine content of decaffeinated coffee. J Anal Toxicol, 2006, 30(8): 611-613.
27.	Moore SC, Gierach GL, Schatzkin A, et al. Physical activity, sedentary behaviours, and the prevention of endometrial cancer. British Journal of Cancer, 2010, 103(7): 933-938.
28.	Zhou B, Yang L, Sun Q, et al. Cigarette Smoking and the Risk of Endometrial Cancer: A Meta-Analysis. The American Journal of Medicine, 2008, 121(6): 501-508.e503.

1. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA: A Cancer Journal for Clinicians, 2011, 61(2): 69-90.
2. Akhmedkhanov A, Zeleniuch-Jacquotte A, Toniolo P. Role of Exogenous and Endogenous Hormones in Endometrial Cancer. Annals of the New York Academy of Sciences, 2001, 943(1): 296-315.
3. Yu X, Bao Z, Zou J, et al. Coffee consumption and risk of cancers: a meta-analysis of cohort studies. BMC Cancer, 2011, 11(1): 96.
4. Kaaks R, Lukanova A, Kurzer MS. Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. Cancer Epidemiol Biomarkers Prev, 2002, 11(12): 1531-1543.
5. Je Y, Giovannucci E. Coffee consumption and risk of endometrial cancer: Findings from a large up-to-date meta-analysis. Int J Cancer, 2012, 131(7): 1700-1710.
6. Bravi F, Scotti L, Bosetti C, et al. Coffee drinking and endometrial cancer risk: a metaanalysis of observational studies. American Journal of Obstetrics and Gynecology, 2009, 200(2): 130-135.
7. Wells G, Shea B, O’Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2010. Available from: URL: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
8. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA, 2000, 283(15): 2008-2012.
9. Greenland S, Longnecker MP. Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. Am J Epidemiol, 1992, 135(11): 1301-1309.
10. Orsini N, Bellocco R, Greenland S. Generalized least squares for trend estimation of summarized dose-response data. The Stata Journal, 2006, 6(1): 40-57.
11. Friberg E, Orsini N, Mantzoros CS, et al. Coffee drinking and risk of endometrial cancer-A population-based cohort study. International Journal of Cancer, 2009, 125(10): 2413-2417.
12. Je Y, Hankinson SE, Tworoger SS, et al. A Prospective Cohort Study of Coffee Consumption and Risk of Endometrial Cancer over a 26-Year Follow-Up. Cancer Epidemiology Biomarkers & Prevention, 2011, 20(12): 2487-2495.
13. Stensvold I, Jacobsen BK. Coffee and cancer: a prospective study of 43,000 Norwegian men and women. Cancer Causes Control, 1994, 5(5): 401-408.
14. Uccella S, Mariani A, Wang A, et al. Coffee consumption and the risk of endometrial cancer in postmenopausal women. Gynecol Oncol, 2010, 116(3): S75-S76.
15. Jacobsen BK, Bjelke E, Kvale G, et al. Coffee drinking, mortality, and cancer incidence: results from a Norwegian prospective study. J Natl Cancer Inst, 1986, 76(5): 823-831.
16. Gavrilyuk O, Braaten T, Skeie G, et al. Coffee consumption and endometrial cancer risk among postmenopausal women in the norwegian women and cancer (NOWAC) study. International Journal of Gynecological Cancer, 2011, 21(12 SUPPL. 3): S509.
17. Shimazu T, Inoue M, Sasazuki S, et al. Coffee consumption and risk of endometrial cancer: A prospective study in Japan. International Journal of Cancer, 2008, 123(10): 2406-2410.
18. Nilsson LM, Johansson I, Lenner P, et al. Consumption of filtered and boiled coffee and the risk of incident cancer: a prospective cohort study. Cancer Causes & Control, 2010, 21(10): 1533-1544.
19. Giri A, Sturgeon SR, Luisi N, et al. Caffeinated Coffee, Decaffeinated Coffee and Endometrial Cancer Risk: A Prospective Cohort Study among US Postmenopausal Women. Nutrients, 2011, 3(11): 937-950.
20. Gunter MJ, Schaub JA, Xue X, et al. A prospective investigation of coffee drinking and endometrial cancer incidence. International Journal of Cancer, 2012, 131(4): E530-E536.
21. Goto A, Song Y, Chen BH, et al. Coffee and Caffeine Consumption in Relation to Sex Hormone-Binding Globulin and Risk of Type 2 Diabetes in Postmenopausal Women. Diabetes, 2010, 60(1): 269-275.
22. van Dieren S, Uiterwaal CS, van der Schouw YT, et al. Coffee and tea consumption and risk of type 2 diabetes. Diabetologia, 2009, 52(12): 2561-2569.
23. Cavin C, Holzhaeuser D, Scharf G, et al. Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity. Food and Chemical Toxicology, 2002, 40(8): 1155-1163.
24. Butt MS, Sultan MT. Coffee and its consumption: benefits and risks. Crit Rev Food Sci Nutr, 2011, 51(4): 363-373.
25. Khan N, Afaq F, Mukhtar H. Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxid Redox Signal, 2008, 10(3): 475-510.
26. McCusker RR, Fuehrlein B, Goldberger BA, et al. Caffeine content of decaffeinated coffee. J Anal Toxicol, 2006, 30(8): 611-613.
27. Moore SC, Gierach GL, Schatzkin A, et al. Physical activity, sedentary behaviours, and the prevention of endometrial cancer. British Journal of Cancer, 2010, 103(7): 933-938.
28. Zhou B, Yang L, Sun Q, et al. Cigarette Smoking and the Risk of Endometrial Cancer: A Meta-Analysis. The American Journal of Medicine, 2008, 121(6): 501-508.e503.

Chinese Journal of Evidence-Based Medicine

Correlation between Coffee and Risk of Endometrial Cancer: A Meta-Analysis

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