A Chinese introduction to intervention synthesis questions (InSynQ) checklist_Chinese Journal of Evidence-Based Medicine

Authors：

PANG Xiao , HUANG Yan , GOU Pan ,  LIU Chang , WANG Liao ,  LIU Jiyuan

State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

LIU Chang, Email: liu_chang_92@sina.com; LIU Jiyuan, Email: wchsljy@scu.edu.cn

Keywords：

Systematic review; Intervention; Reporting guideline; Data synthesis; Meta-analysis; PICO

DOI：

10.7507/1672-2531.202407142

Video：

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The planning and reporting of synthesis questions in systematic review of intervention have a direct and important impact on the validity of the evaluation and the credibility of the results. Planning helps to reduce bias in the evaluation process and ensure the reproducibility of data synthesis. However, the field of systematic review currently lacks specific checklists and tools to guide how to plan and report these issues. The InSynQ (Intervention Synthesis Questions) checklist is a tool designed for planning and reporting data synthesis issues in systematic reviews of interventions. Its goal is to promote the standardization of systematic review methods, support systematic review participants in planning and comprehensively reporting data synthesis issues and structures, and provide a more accurate evidence base for clinical decision-making.

Citation： PANG Xiao, HUANG Yan, GOU Pan, LIU Chang, WANG Liao, LIU Jiyuan. A Chinese introduction to intervention synthesis questions (InSynQ) checklist. Chinese Journal of Evidence-Based Medicine, 2025, 25(6): 696-703. doi: 10.7507/1672-2531.202407142 Copy

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17.	李庚, 欧阳文伟, 周莉, 等. 无Meta分析数据合成(SWiM)的系统评价报告规范. 中国循证医学杂志, 2020, 20(11): 1359-1364.
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1. McKenzie JE, Beller EM, Forbes AB. Introduction to systematic reviews and meta-analysis. Respirology, 2016, 21(4): 626-637.
2. Lasserson TJ, Thomas J, Higgins JPT. Chapter 1: starting a review. In: Higgins JPT, Thomas J, Chandler J, et al. Cochrane handbook for systematic reviews of interventions. 2022.
3. Thomas J, Kneale DM, Brennan JE, et al. Chapter 2: determining the scope of the review and the questions it will address. In: Higgins JPT, Thomas J, Chandler J, et al. Cochrane handbook for systematic reviews of interventions. 2022.
4. Stratil JM, Biallas RL, Burns J, et al. Non-pharmacological measures implemented in the setting of long-term care facilities to prevent SARS-CoV-2 infections and their consequences: a rapid review. Cochrane Database Syst Rev, 2021, 9(9): CD015085.
5. Bergman H, Henschke N, Hungerford D, et al. Vaccines for preventing rotavirus diarrhoea: vaccines in use. Cochrane Database Syst Rev, 2021, (11): CD008521.
6. McKenzie JE, Brennan SE, Ryan RE, et al. Chapter 3: defining the criteria for including studies and how they will be grouped for the synthesis. In: Higgins JPT, Thomas J, Chandler J, et al. Cochrane handbook for systematic reviews of interventions. 2022.
7. Shea BJ, Reeves BC, Wells G, et al. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ, 2017, 358: j4008.
8. Whiting P, Savović J, Higgins JP, et al. ROBIS: a new tool to assess risk of bias in systematic reviews was developed. J Clin Epidemiol, 2016, 69: 225-234.
9. Brennan SE, Cumpston MS, Ryan R, et al. InSynQ (Intervention Synthesis Questions) checklist and guide for developing and reporting the questions addressed in systematic reviews of interventions. 2023.
10. 王雅琪, 高一城, 苏澄元, 等. 临床实践指南中临床问题结构化分级及评价. 中国循证医学杂志, 2024, 24(7): 827-831.
11. Cumpston MS, McKenzie JE, Ryan R, et al. Development of the InSynQ checklist: a tool for planning and reporting the synthesis questions in systematic reviews of interventions. Cochrane Evidence Synth Methods, 2023, 1(10): e12036.
12. Brust L, Schmidt-Wolf I, Weigl M. The impact of patient engagement on patient safety in care transitions after cancer treatment: protocol for a systematic review and meta-analysis. PLoS One, 2024, 19(8): e0307831.
13. Page MJ, Moher D, Bossuyt PM, et al. PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ, 2021, 372: n160.
14. 高亚, 刘明, 杨珂璐, 等. 系统评价报告规范: PRISMA2020与PRISMA2009的对比分析与实例解读. 中国循证医学杂志, 2021, 21(5): 606-616.
15. Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, 2021, 372: n71.
16. Campbell M, McKenzie JE, Sowden A, et al. Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline. BMJ, 2020, 368: l6890.
17. 李庚, 欧阳文伟, 周莉, 等. 无Meta分析数据合成(SWiM)的系统评价报告规范. 中国循证医学杂志, 2020, 20(11): 1359-1364.
18. Higgins JP, Lasserson T, Thomas J, et al. Methodological expectations of Cochrane intervention reviews (MECIR) Version August 2023. 2023.
19. Hutton B, Salanti G, Caldwell DM, et al. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med, 2015, 162(11): 777-784.
20. McKenzie JE, Brennan SE, Ryan RE, et al. Chapter 9: summarizing study characteristics and preparing for synthesis. In: Higgins JPT, Thomas J, Chandler J, et al. Cochrane handbook for systematic reviews of interventions. 2022.
21. RevManWeb Knowledge Base. What is study centric data management? 2023.

Chinese Journal of Evidence-Based Medicine

A Chinese introduction to intervention synthesis questions (InSynQ) checklist

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