• 1. Department of Stomatology, the Third People’s Hospital of Chengdu, Chengdu 610041, P. R. China;
  • 2. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P. R. China;
LIU Chang, Email: liu_chang_92@sina.com; FANG Hongzhi, Email: 1127958575@qq.com
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Objective To systematically interpret the updated Risk of Bias in Non-randomized Studies of Interventions Version 2 (ROBINS-I V2) in 2024, summarizing its key improvements, operational procedures, and clinical application value. Methods Through literature review and case studies, the improvements of ROBINS-I V2 were compared with the 2016 version, including the expansion of bias domains, refinement of signaling questions, and optimization of decision flowcharts. A retrospective study in stomatology was used to demonstrate the practical application of the tool. Results The ROBINS-I V2 tool has restructured the hierarchy and refined the definitions of bias domains, optimized the evaluation processes across seven risk-of-bias dimensions, and minimized subjective judgment errors through standardized decision flowcharts. Conclusion ROBINS-I V2 significantly improves the rigor of bias assessment in non-randomized intervention studies through its scientific design and standardized workflow. It is recommended for evidence quality grading and decision-making support in clinical research.

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