A Three-Month Non-Interventional Study of Asthma Treatment with Budesonide/Formoterol_Chinese Journal of Respiratory and Critical Care Medicine

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Department of Respiratory Medicine, Shanghai First People’s Hospital, Shanghai Jiaotong University. hanghai, 200080, China.;

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Keywords：

Budesonide/ formoterol; Asthma; Therapy

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Objective To evaluate the efficacy of Budesonide / formoterol to control asthma under real-life conditions. Methods A multi-center, open label, non-interventional study was conducted. Asthma control after 12 week therapy with Budesonide/ formoterol was assessed by Asthma Control Questionnaire( ACQ) and modified Asthma Control Questionnaire ( ACQ5) . Results A total of 360 asthma patients were recruited, including 228 adult patients and 132 child patients. After 12 weeks’ therapy, all the patients’medium value of ACQ was decreased significantly from 2. 03 ( adults 2. 20, children 1. 74) at baseline to 0. 60 ( adults 0. 78, children 0. 29) ( P lt; 0. 0001 ) , and the medium value of ACQ5 was also decreased significantly from2. 4 ( adults 2. 24, children 1. 76) at baseline to 0. 47 ( adults 0. 62, children 0. 20) ( P lt;0. 0001) . Conclusion Budesonide / formoterol is effective in asthma treatment, by which most asthma patients obtain and maintain clincal control.

Citation： ZHOU Xin,HONG Jianguo,XINJianbao,WUChanggui,BO Jianping,ZHANG Tiantuo,WANGChangzheng,CAI Shaoxi,LIU Chun,QIU Chen,HUANG Jianan,LAI Guoxiang,KONG Lingfei,LIU Chuntao,MA Zhuang,HUANGKewu,YANG Heping,ZHOU Jianying,CHENGZhuochang,SUN Peizong,SUN Genyun,WANG Libo,TANG Suping,CHEN Zhimin,LI Changchong,ZHAO Deyu,LIN Rongjun,ZHENG Yuejie,XIANG Li,ZHOU Xiaoqing,CHENG Yuzhi. The authors are listed here in no particular order.Corresponding Author. A Three-Month Non-Interventional Study of Asthma Treatment with Budesonide/Formoterol. Chinese Journal of Respiratory and Critical Care Medicine, 2009, 09(4): 341-344. doi: Copy

1.	殷凯生. 以临床控制作为防治哮喘的目标. 实用临床医药杂志, 2008, 12, 1-2.
2.	Bateman ED, Boushey HA, Bousquet J, et al. Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study. Am J Respir Crit Care Med, 2004, 170: 836-844.
3.	O’Byrne PM. Global Strategy for asthma management and prevention [ DB/ CL] . Hamilton; GINA Executive Committee, 2006 [ 2007-7-11] . http: / / www. Ginaasthma. com.
4.	林江涛, 李龙芸, 陈萍, 等. 吸入布地奈德/ 福莫特罗干粉剂与联合吸入两种干粉剂治疗支气管哮喘的疗效和安全性研究. 中华结核和呼吸杂志, 2006, 29: 421-423.
5.	刘春涛. 中重度哮喘治疗方案的调整. 中国呼吸与危重监护杂志, 2008, 7: 329-331.
6.	Scicchitano R, Aalbers R, Ukena D, et al. Efficacy and safety of budesonide/ formoterol single inhaler therapy versus a higher dose of budesonide in moderate to severe asthma. Curr Med Res Opin,2004, 20: 1403-1418.
7.	周新. 支气管哮喘控制的评估方法. 中华结核和呼吸杂志,2008, 31: 166-168.
8.	JuniperEF,O’Byrne PM, Guyatt GH, et al. Development and validation of a questinonair to measure asthma control. Eur Respir J, 1999, 14: 902-907.
9.	Barnes PJ. Scientific rationale for using a single inhaler for asthma control. Eur Respir J, 2007, 29: 587-595.
10.	O’Byrne PM, Bisgaard H, Godard PP, et al. Budesonide /formaoterol combination therapy as both maintenance and reliever medication in asthma. Am J Respir Crit Med, 2005, 171: 129-136.
11.	Rabe KF, Pizzichini E, Stalberg B, et al. Budersonide / formoterol in a inhaler for maintenance and relief in mild to moderate asthma:a randomized, double-blind trial. Chest, 2006, 129: 246-256.

1. 殷凯生. 以临床控制作为防治哮喘的目标. 实用临床医药杂志, 2008, 12, 1-2.
2. Bateman ED, Boushey HA, Bousquet J, et al. Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study. Am J Respir Crit Care Med, 2004, 170: 836-844.
3. O’Byrne PM. Global Strategy for asthma management and prevention [ DB/ CL] . Hamilton; GINA Executive Committee, 2006 [ 2007-7-11] . http: / / www. Ginaasthma. com.
4. 林江涛, 李龙芸, 陈萍, 等. 吸入布地奈德/ 福莫特罗干粉剂与联合吸入两种干粉剂治疗支气管哮喘的疗效和安全性研究. 中华结核和呼吸杂志, 2006, 29: 421-423.
5. 刘春涛. 中重度哮喘治疗方案的调整. 中国呼吸与危重监护杂志, 2008, 7: 329-331.
6. Scicchitano R, Aalbers R, Ukena D, et al. Efficacy and safety of budesonide/ formoterol single inhaler therapy versus a higher dose of budesonide in moderate to severe asthma. Curr Med Res Opin,2004, 20: 1403-1418.
7. 周新. 支气管哮喘控制的评估方法. 中华结核和呼吸杂志,2008, 31: 166-168.
8. JuniperEF,O’Byrne PM, Guyatt GH, et al. Development and validation of a questinonair to measure asthma control. Eur Respir J, 1999, 14: 902-907.
9. Barnes PJ. Scientific rationale for using a single inhaler for asthma control. Eur Respir J, 2007, 29: 587-595.
10. O’Byrne PM, Bisgaard H, Godard PP, et al. Budesonide /formaoterol combination therapy as both maintenance and reliever medication in asthma. Am J Respir Crit Med, 2005, 171: 129-136.
11. Rabe KF, Pizzichini E, Stalberg B, et al. Budersonide / formoterol in a inhaler for maintenance and relief in mild to moderate asthma:a randomized, double-blind trial. Chest, 2006, 129: 246-256.

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Chinese Journal of Respiratory and Critical Care Medicine

A Three-Month Non-Interventional Study of Asthma Treatment with Budesonide/Formoterol

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