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find Keyword "无创正压通气" 38 results
  • Risk factors associated with failure of noninvasive positive pressure ventilation in acute respiratory failure due to acute exacerbation of chronic obstructive pulmonary disease

    Objective To analyze the risk factors of treatment failure by noninvasive positive pressure ventilation (NPPV) in patients with acute respiratory failure (ARF) due to acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and explore the best time that NPPV be replaced by invasive ventilation when NPPV failure occurs. Methods The data of patients with ARF due to AECOPD who were treated with NPPV from January 2013 to December 2015 were retrospectively collected. The patients were divided into two groups: the NPPV success group and the NPPV failure group (individuals who required endotracheal intubation or tracheotomy at any time). The Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ score was analyzed; the Glasgow Coma Scale score, respiratory rate (RR), pH value, partial pressure of oxygen (PaO2), PaO2/fraction of inspired oxygen (FiO2) ratio, and partial pressure of carbon dioxide were also analyzed at admission, after 2 hours of NPPV, and after 24 hours of NPPV. Results A total of 185 patients with ARF due to AECOPD were included. NPPV failed in 35.1% of the patients (65/185). Multivariate analysis identified the following factors to be independently associated with NPPV failure: APACHEⅡscore≥30 [odds ratio (OR)=20.603, 95% confidence interval (CI) (5.309, 80.525), P<0.001], RR at admission≥35 per minute [OR=3.723, 95%CI (1.197, 11.037), P=0.020], pH value after 2 hours of NPPV<7.25 [OR=2.517, 95%CI (0.905, 7.028), P=0.070], PaO2 after 2 hours of NPPV<60 mm Hg (1 mm Hg=0.133 kPa) [OR=3.915, 95%CI (1.374, 11.508), P=0.010], and PaO2/FiO2 after 2 hours of NPPV<200 mm Hg [OR=4.024, 95%CI (1.542, 11.004), P=0.010]. Conclusion When patients with ARF due to AECOPD have a higher severity score, have a rapid RR at admission, or fail to improve in terms of pH and oxygenation after 2 hours of NPPV, the risk of NPPV failure is higher.

    Release date:2017-11-24 10:58 Export PDF Favorites Scan
  • 重症加强治疗病房无创正压通气患者应用镇静治疗的安全性探讨

    目的探讨丙泊酚在无创正压通气镇静中应用的疗效及安全性。 方法回顾分析南方医科大学附属中山市小榄人民医院重症加强治疗病房(ICU)对133例呼吸衰竭患者在各种原因导致不配合无创通气的情况下,静脉泵入丙泊酚进行无创通气的临床资料。首先给予丙泊酚静脉注射进行镇静诱导,然后改用微量注射泵持续注射丙泊酚,根据Ramsay氏分级标准调整用量,观察镇静后患者无创通气的效果及生命体征的变化、无创通气的并发症等。 结果133例患者中,112例无创通气效果良好,生命体征逐渐稳定;21例失败,改用气管插管机械通气治疗。失败原因分别为:镇静效果差,患者仍烦躁不安、通气效果差;缺氧及二氧化碳潴留无改善;腹胀、呕吐、误吸、呼吸疲劳等。 结论适度镇静可提高无创通气成功率和通气效果,避免有创机械通气带来的不良作用,在ICU严密监测下使用具有良好的安全性,值得临床应用。

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  • 无创正压通气治疗慢性阻塞性肺疾病合并呼吸衰竭的护理

    【摘要】 目的 探讨无创正压通气治疗慢性阻塞性肺疾病合并呼吸衰竭的护理措施。 方法 回顾性分析2006年1月-2008年12月使用无创正压通气治疗合并呼吸衰竭的慢性阻塞性肺疾病患者的临床资料,比较其使用呼吸机前后的症状、舒适性、体温、心率及血气分析的变化。 结果 使用无创正压通气治疗后患者症状改善,无明显不适感,体温、心率趋于平稳,缺氧、高碳酸血症得到明显改善。 结论 无创正压通气治疗慢性阻塞性肺疾病合并呼吸衰竭易于护理,效果显著。

    Release date:2016-09-08 09:50 Export PDF Favorites Scan
  • 重症肺炎合并Ⅰ型呼吸衰竭经鼻高流量湿化氧疗临床效果评价

    目的 对比文丘里面罩吸氧及无创正压通气(NPPV),评价经鼻高流量湿化氧疗(HFNC)在重症肺炎Ⅰ型呼吸衰竭患者中应用效果。方法 选择 2017 年 3 月至 2019 年 12 月我院呼吸与危重症医学科重症肺炎合并Ⅰ型呼吸衰竭经文丘里面罩吸氧、HFNC 及 NPPV 治疗患者 142 例。随机数字表法分为文丘里面罩吸氧组为面罩组 46 例,HFNC 组 49 例,NPPV 组 47 例,分别比较治疗后 2 h 三组患者 SpO2、PaO2、PaO2/FiO2、PaCO2、pH、RR、HR、舒适度、耐受性程度、鼻腔干燥程度、咽喉干燥程度、咳痰难易程度、气管插管率。结果 HFNC 组与面罩组间 SpO2、PaO2、PaO2/FiO2 差异有统计学意义(均 P<0.05),HFNC 组与 NPPV 组间SpO2差异无统计学意义(P>0.05);HFNC 组与 NPPV 组间 PaO2、PaO2/FiO2 差异有统计学意义(均 P<0.05);三组间 PaCO2、pH、RR、HR 差异无统计学意义(P>0.05)。HFNC 组与 NPPV 组间舒适度、耐受性、鼻腔干燥程度、咽喉干燥程度、咳痰难易程差异有统计学意义(P<0.05);HFNC 组与面罩组鼻腔黏膜干燥程度、咳痰难易程度、气管插管差异有统计学意义(均 P<0.05),NPPV 组与面罩组间气管插管差异有统计学意义(P<0.05);HFNC 组与 NPPV 组间气管插管差异无统计学意义(P>0.05)。结论 HFNC 可应用于重症肺炎Ⅰ型呼吸衰竭早期呼吸支持治疗,患者依从性好,不良反应少,临床治疗效果肯定,值得在临床推广。

    Release date:2021-11-18 04:57 Export PDF Favorites Scan
  • Effects of Enteral Tube Feeding on Moderate AECOPD Patients Received Noninvasive Positive Pressure Ventilation

    Objective To explore the effects of enteral tube feeding on moderate AECOPD patients who underwent noninvasive positive pressure ventilation ( NPPV) . Methods Sixty moderate AECOPD patients with NPPV admitted from January 2009 to April 2011 were recruited for the study. They were randomly divided into an enteral tube feeding group (n=30) received enteral tube feeding therapy, and an oral feeding group (n=30) received oral feeding therapy. Everyday nutrition intake and accumulative total nutrition intake in 7 days, plasma level of prealbumin and transferrin, success rate of weaning, duration of mechanical ventilation, length of ICU stay, rate of trachea cannula, and mortality rate in 28 days were compared between the two groups. Results Compared with the oral feeding group, the everyday nutrition intake and accumulative total nutrition intake in 7 days obviously increased (Plt;0.05) , while the plasma prealbumin [ ( 258.4 ±16.5) mg/L vs. (146.7±21.6) mg/L] and transferrin [ ( 2.8 ±0.6) g/L vs. ( 1.7 ±0.3) g/L] also increased significantly after 7 days in the enteral tube feeding group( Plt;0.05) . The success rate of weaning ( 83.3% vs. 70.0%) , the duration of mechanical ventilation [ 5. 6( 3. 2-8. 6) days vs. 8. 4( 4. 1-12. 3) days] , the length of ICU stay [ 9. 2( 7. 4-11. 8) days vs. 13. 6( 8.3-17. 2) days] , the rate of trachea cannula ( 16. 6% vs. 30. 0% ) , the mortality rate in 28 days ( 3. 3% vs. 10. 0% ) all had significant differences between the enteral tube feeding group and the oral feeding group. Conclusions For moderate AECOPD patients with NPPV, enteral tube feeding can obviously improve the condition of nutrition and increase the success rate of weaning, shorten the mechanical ventilation time and the mean stay in ICU, decrease the rate of trachea cannula and mortality rate in 28 days. Thus enteral tube feeding should be preferred for moderate AECOPD patients with NPPV.

    Release date:2016-09-13 04:00 Export PDF Favorites Scan
  • Clinical Investigation of Non-Invasive Positive Pressure Ventilation in Treatment for Patients with Chronic Obstructive Pulmonary Disease and Severe Respiratory Failure

    目的:评价无创正压通气(NIPPV)在救治慢性阻塞性肺疾病(COPD)急性加重期并严重呼吸衰竭患者中的临床疗效。方法:对2006年1月至2008年1月入选的47例COPD急性加重期并严重呼吸衰竭患者使用双水平无创正压呼吸机面罩辅助通气, 患者均伴有不同程度的意识障碍,动态观察NIPPV治疗前和治疗后2 h、8 h、1 d及3 d动脉血气、神志、治疗后患者的转归,NIPPV的不良反应及并发症。结果:本组47例患者中,41例经NIPPV治疗2 h、8 h、1 d及3 d后与治疗前比较,PaO2明显升高Plt;0.01,PaCO2明显降低Plt;0.01,pH明显升高Plt;0.01,均脱机出院,有效率达87.23%(41/47);6例改为有创通气,其中3例经有创机械通气治疗后脱机成功,1例因上消化道出血死亡,2例自动出院.结论:双水平无创正压通气对有选择的COPD急性加重期并严重呼吸衰竭患者治疗疗效确切,它能迅速缓解病情,减少患者的气管插管和气管切开以及相应的并发症,提高生活质量。

    Release date:2016-09-08 10:01 Export PDF Favorites Scan
  • Clinical Efficacy of Noninvasive Positive-pressure Ventilation for Elderly Patients with Chronic Obstructive Pulmonary Disease Combined with Left Heart Failure

    ObjectiveTo investigate the effect of noninvasive positive-pressure ventilation for elderly patients with chronic obstructive pulmonary disease (COPD) combined with left heart failure. MethodsA total of 152 patients (70-85 years old) diagnosed with COPD combined with left heart failure and treated in our hospital between June 2011 and January 2015 were randomly divided into trial group (noninvasive positive-pressure ventilation with routine treatment, n=76) and control group (routine treatment, n=76). Respiratory rate, heart rate, blood pressure, pH, arterial partial pressure of carbon dioxide (PaCO2), arterial partial pressure of oxygen (PaO2) and left ventricular ejection fraction (LVEF) were analyzed and compared between the two groups after treatment. We did t-test to analyze the difference of these indexes between the two groups statistically. ResultsRespiratory rate, heart rate and PaCO2 in both of the two groups after the treatment were significantly lower than those before the treatment (P<0.001), while PaO2 and LVEF in both of the two groups after the treatment were significantly higher than those before the treatment (P<0.001). The systolic pressure and diastolic pressure in both of the two groups after the treatment didn't differ much from those before the treatment (P>0.05). The pH value after the treatment increased only in the trial group compared with that before the treatment (P<0.05). The respiratory rate, heart rate, pH value, PaO2, PaCO2 and LVEF after the treatment in trial group were meliorated compared with those in the control group (P<0.05). ConclusionTreatment with noninvasive positive-pressure ventilation for elderly patients with COPD combined with left heart failure is more efficient than the routine treatment.

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  • Application of Dexmedetomidine Hydrochloride in Sedation Practices during NPPV for Patients with Acute Exacerbations of COPD and Respiratory Failure

    Objective To investigate the feasibility of dexmedetomidine hydrochloride in sedation practices during NPPV for patients with acute exacerbation of COPD ( AECOPD) and respiratory failure. Methods 50 patients with AECOPD and respiratory failure, admitted in ICU between January 2011 and April 2012, were divide into an observation group and a control group. All patients received conventional treatment and noninvasive positive pressure ventilation ( NPPV) . Meanwhile in the observation group, dexmedetomidine hydrochloride ( 1 μg/kg) was intravenously injected within 10 minutes, then maintained using a micropump by 0.1 ~0. 6 μg·kg- 1 ·h- 1 to maintaining Ramsay Sedation Scale ( RSS) score ranged from 2 to 4. The patients’compliance to NPPV treatment ( conversion rate to invasive ventilation) and ICU stay were compared between two groups. Heart rate,mean arterial pressure, respiratory rate, and arterial blood gas ( pH, PaO2 , PaCO2 ) before and 24 hours after treatment were also compared. Results After 24 hours treatment, heart rate, mean arterial pressure, respiratory rate, and arterial blood gas were all improved in two groups, while the improvements were more remarkable in the observation group. The conversion rate to invasive ventilation ( 4% vs. 16% ) and ICUstay [ ( 5.47 ±3.19) d vs. ( 8.78 ±3.45) d] were lower in the observation group than those in the control group. ( P lt;0.05) . Conclusion Dexmedetomidine hydrochloride may serve as a safe and effective sedative drug during NPPV in patients with AECOPD and respiratory failure.

    Release date:2016-09-13 03:46 Export PDF Favorites Scan
  • Efficacy of home noninvasive positive pressure ventilation on patients with severe stable chronic obstructive pulmonary disease in China: a meta-analysis

    Objective To systematically evaluate the efficacy of home noninvasive positive pressure ventilation (HNPPV) on patients with severe stable chronic obstructive pulmonary disease in China. Methods Systematic literature search was performed in Chinese BioMedical Literature Database, WanFang Data, VIP Database, Chinese National knowledge Infrastructure databases from inception to January 2018. All randomized controlled trials (RCTs) that reported comparison of the efficacy of HNPPV on patients with severe stable chronic obstructive pulmonary disease were included. All related data were extracted. Meta-analysis was conducted using the statistical software RevMan 5.3 on the basis of strict quality evaluation. Results A total of 767 patients from 14 studies were included in this meta-analysis. The combined results showed that, compared with the control group, HNPPV could significantly reduce the mortality (relative risk 0.51, 95%CI 0.33 – 0.78, P=0.002) and PaCO2 [weighted mean difference (MD) –10.78, 95%CI –13.17 – –8.39, P<0.000 01] of patients, improve the levels of PaO2 (MD 7.84, 95%CI 5.81 – 9.87, P<0.000 01), FEV1 (MD 0.13, 95%CI 0.08 – 0.18, P<0.000 01), and the quality of life (MD –6.27, 95% CI –9.04 – –3.51, P<0.000 01). Conclusion HNPPV can reduce the mortality of patients, improve the gas exchange, pulmonary function and the quality of life, but more large sample, high-quality, and multicenter RCT studies are needed.

    Release date:2019-05-23 04:40 Export PDF Favorites Scan
  • Physiological Effects of Oxygen Injection Site during Noninvasive Positive Pressure Ventilation

    Objective To investigate the physiological effects of different oxygen injection site on ventilatory status and oxygenation during noninvasive positive pressure ventilation ( NPPV) with portable noninvasive ventilators. Methods A prospective crossover randomized study was performed. Oxygen injection site was randomized into the outlet of the ventilator, the connection site between mask and circuit, and the mask under the condition of leak port immobilized in the mask. Oxygen flow was retained in the baseline level at the initial 5 to 10 minutes, and adjusted to obtain arterial oxygen saturation measured by pulse oximetry ( SpO2 ) ranging from 90% to 95% after SpO2 remains stable. SpO2 at the initial 5 to 10 minutes, oxygen flow, ventilatory status, oxygenation, hemodynamics and dyspnea indexes at0. 5 hour, 1 hour, and 2 hours of NPPV were compared between different oxygen injection sites. Results 10 patients were recruited into the study. Under the condition of the same oxygen flow, SpO2 with oxygen injection site in the outlet of the ventilator was significantly higher than that with oxygen injection site in the connection site between mask and circuit [ ( 98.9 ±0.9) % vs. ( 96.9 ±1.1) % , P =0. 003] , whereas SpO2 with oxygen injection site in the connection site between mask and circuit was significantly higher than that with oxygen injection site in the mask [ ( 96.9 ±1.1) % vs. ( 94.1 ±1.6) %, P = 0.000] . Oxygen flow with oxygen injection site in the mask was statistically higher than that with oxygen injection site at other sites ( P lt; 0.05) . Arterial oxygen tension/ oxygen flow with oxygen injection site in the outlet of the ventilator was significantly higher than that with oxygen injection site in the connection site between mask and circuit ( 67.9 ±31.1 vs. 37.0 ±15.0, P =0.007) , and than that with oxygen injection site in the mask ( 67.9 ± 31.1 vs. 25.0 ±9.1, P = 0.000) . pH, arterial carbon dioxide tension, hemodynamics and dyspnea indexes were not significantly different between different oxygen injection sites ( P gt; 0.05) .Conclusions When portable noninvasive ventilator was applied during NPPV, oxygen injection site significantly affects improvement of oxygenation, and shows a trend for affecting ventilatory status and work of breathing. When the leak port was immobilized in the mask, the nearer oxygen injection site approaches the outlet of the ventilator, the more easily oxygenation is improved and the lower oxygen flow is demanded.

    Release date:2016-09-13 03:53 Export PDF Favorites Scan
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