Objective To investigate the differences of postoperative quality of life （QOL） between proximal gas-trectomy （PG） and total gastrectomy （TG） in patients with adenocarcinoma of esophagogastric junction （AEG）. Methods Eighty five patients with AEG （Siewert type Ⅱ or Ⅲ） who were underwent PG or TG surgery between Jan. 2011 andMar. 2012 at West China Hospital of Sichuan University were enrolled， to measure the QOL by using the Chineseversion of quality of life questionnaire core-30 （QLQ-C30） and the site-specific module for gastric cancer （QLQ-STO22）which were drawed up by the European Organization for Research and Treatment of Cancer （EORTC） in 12 months afteroperation. Results There were no any difference of clinicopathological features between patients in 2 groups （P＞0.05），such as age， gender， and so on. The scores of eating restriction， diarrhea， and dyspnea in PG group were lower than those of TG group （P＜0.05）， but scores of reflux and taste change were higher （P＜0.05）， no other significant differ-ence was found between the patients of 2 groups （P＞0.05）. Conclusion Both of PG＋gastric tube reconstruction and TG＋Roux-en-Y anastomosis in treatment of patients with Siewert type Ⅱ or Ⅲ AEG may lead to complications， but patients who underwent former surgery have better situation in eating restriction， diarrhea， and dyspnea， and patients who underwent later surgery have better situation in reflux and taste change.
ObjectiveTo investigate the application of three methods about digestive tract reconstruction in radical resection for proximal gastric cancer.MethodsWe retrospectively reviewed the cases of 130 proximal gastric cancer patients who underwent double tract reconstruction (TD, 35 cases), total gastrectomy (TG, 50 cases) and esophagogastrostomy (EG, 45 cases) from Jan. 2016 to Oct. 2018 in Gastrointestinal Surgery Department in our Hospital.ResultsThere were no significant differences in basic data of patients, preoperative nutritional status, hemoglobin content, postoperative recovery time of gastrointestinal function, hospitalization time and early postoperative complications among the three groups (P>0.05). But the operative time, intraoperative bleeding volume, postoperative status of total protein, albumin, hemoglobin, late complications, reflux symptoms, gastro-intestinal quality of life index (GIQLI) between the three groups had statistically significant differences (P<0.05). The operative time of EG was (161.80±30.77) min, which was the shortest. The intraoperative bleeding volume of TG was (107.20±10.70) mL, which was the most. At 6 months after TG, the total protein, albumin and hemoglobin were (62.15±6.72) g/L, (36.14±6.57) g/L and (112.68±16.97) g/L, respectively, which were the lowest level among the three groups. There late complications of the EG were the most serious, in which the Visick score was 46 and the GIQLI index was 103.56±22.01. The above differences were statistically significant (P<0.05).ConclusionsDT performs better in anti-reflux, maintenance of postoperative nutrition, and anti-anemia, but the occurrence of remnant gastric cancer is a potential risk. TG has a lot of bleeding, as well as the performance of postoperative nutrition and anti-anemia is not good, but it can avoid the occurrence of remnant gastric cancer. The operative time of EG is short, but reflux symptoms are more likely to occur after surgery, and the quality of life is bad.
ObjectiveTo summarize the research progress of functional surgery in upper and middle gastric cancer.Method" functional gastric surgery” " pylorus-preserving gastrectomy” and " proximal gastrectomy” were used as search terms to retrieve the literatures, and various surgical methods and their application status were reviewed.ResultsFunctional gastric surgery can effectively improve the postoperative quality of life of patients with early gastric cancer in the upper and middle stomach.ConclusionFunctional gastric surgery is a feasible surgical method for early gastric cancer.
ObjectiveTo systematically evaluate the efficacy and safety of proximal gastrectomy (PG) versus total gastrectomy (TG) for the treatment of Siewert type Ⅱ/Ⅲ adenocarcinoma of the esophagogastric junction (AEG). MethodsPubMed, The Cochrane Library, Web of Science, EMbase, CNKI, Wanfang, and VIP databases were searched for literature comparing the efficacy and safety of PG and TG for the treatment of Siewert type Ⅱ/Ⅲ AEG. The search period was from database inception to March 2023. Meta-analysis was performed using Review Manager 5.4 software. ResultsA total of 23 articles were included, including 16 retrospective cohort studies, 5 prospective cohort studies, and 2 randomized controlled trials. The total sample size was 2 826 patients, with 1 389 patients undergoing PG and 1 437 patients undergoing TG. Meta-analysis results showed that compared with TG, PG had less intraoperative blood loss [MD=−19.85, 95%CI (−37.20, −2.51), P=0.02] and shorter postoperative hospital stay [MD=−1.23, 95%CI (−2.38, −0.08), P=0.04]. TG had a greater number of lymph nodes dissected [MD=−6.20, 95%CI (−7.68, −4.71), P<0.001] and a lower incidence of reflux esophagitis [MD=3.02, 95%CI (1.24, 7.34), P=0.01]. There were no statistically significant differences between the two surgical approaches in terms of operative time, postoperative survival rate (1-year, 3-year, 5-year), and postoperative overall complications (P>0.05). ConclusionPG has advantages in terms of intraoperative blood loss and postoperative hospital stay, while TG has advantages in terms of the number of lymph nodes dissected and the incidence of reflux esophagitis. There is no significant difference in long-term survival between the two surgical approaches.